Apoe4

Apoe4

Apoe4 Questions

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by 30 · about 9 hours ago

EDIT: Just found an article that seems to substantiate my hunch, below: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002507/ My original posting: There is probably no correlation because such a wide range of factors--such as genes and... (more)

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Lumifer_1 0 · March 13, 2013 at 1:34 AM

So? You're an introvert. That's a normal state of being. I don't think it's in any way related to your ApoE alleles.

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by 952 · about 9 hours ago

Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)

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Cave_Chick 0 · March 12, 2013 at 10:49 PM

According to 23andme I'm a 4/4 (and 3.1% Neanderthal!) and I notice MUCH better energy, cognition and fat loss when I eat large amounts of coconut oil daily. High quality coconut oil can be expensive, so at times I've stopped buying it to save... (more)

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by 100 · about 9 hours ago

On Jimmy Moore's Ask the Low Carb experts, he had Dr. Steven Gundry on and he said something I've never heard or come across before. He said people with the APO-E4 gene, which is 20% of the population, that a diet high in animal fat is damaging... (more)

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MarkES 0 · January 20, 2013 at 1:59 PM

You can test for it at 23andme.com for $99, includes entire genome, not just ApoE gene. It's specifically the E3/E4, E4/E4 alleles of the ApoE gene that are hyper-responders to dietary fat (25% of the population). Here's some additional info to... (more)

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by 0 · about 9 hours ago

I'll try and keep this concise. I'm currently 6ft and 205 lbs. Late last year I was diagnosed with NAFLD (mild/moderate) as the result of the Dr finding elevated ALT levels in blood work. I've been dealing with some chronic light-headedness... (more)

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Amy_B_ 0 · September 17, 2012 at 8:11 PM

For the NAFLD, you probably want to go lower-carbohydrate - specifically watch the fruit intake. (Fructose does a real number on the liver. A little bit of fruit is okay, but there's a reason NAFLD is getting so common now -- think huge glasses of... (more)

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by 11682 · about 9 hours ago

I can't seem to lower my cholesterol & triglycerides (~290) after a year of Paleo. And I still have a fatty liver. I'm starting to think that I'm an APoE 4/4 carrier, where a high-fat diet just doesn't work as well as in most others (5% of the... (more)

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paleohacks 0 · September 03, 2012 at 12:14 PM

The APOE 4/4 allele is considered a "paleo" version of the APOE gene (1). It's hypothesized that carriers of this allele may be more adapted to a paleo diet, intermittent caloric restriction and exercise than non-carriers. In fact avoidance of a... (more)

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by 78422 · about 9 hours ago

The APOe gene encodes for a protein associated with triglyceride metabolism but its also implicated in Alzheimer's disease. It has been suggested that a variant of the APOe gene - APOe4 - may confer a survival advantage at times of famine (1) -... (more)

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Alex 0 · June 28, 2012 at 3:52 PM

I upgraded my 23andme account specifically so I could see my APOe results. I'm a double E4. I'm also 2.9% Neanderthal.

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by 425 · about 9 hours ago

2 Months ago, I posted a question I'm still hacking on about finding optimum lipid profile for heart/brain health in APOE4 here... http://paleohacks.com/questions/80505/potential-hacks-resolve-heart-brain-dilemma-for-apoe4#axzz1klJhxOz9 I've been... (more)

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Anonymous_Chump 0 · January 28, 2012 at 3:57 PM

Are you doing any high intensity exercising? That seems to make a huge difference in my HDL. Sprints, sprints and more sprints.

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by 180 · about 9 hours ago

First of all, I'm assuming the hypothesis that ApoE4 carriers (one or two alleles) face the problem of high LDL Cholesterol and TC, probably due to a diet high in saturated fat. If that holds true, and according to various blogs (Dr. Davis, Paul... (more)

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Ambimorph 0 · January 02, 2012 at 6:20 PM

23and me gives the following statistics for APO E4. Like you said, although about 20% of people have 1 E4, 2 is much less common. APOE variant frequencies in Europeans Genotype Frequency ??2/??2 0.4% ??2/??3 13.7% ??3/??3 ... (more)

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by 425 · about 9 hours ago

Looking for some suggestions on hacks to resolve what appears to be a heart/brain dilemma associated with apoE4 allele? Experimenting on myself as safer/quick guinea pig for my father. He has been lifelong sufferer of minor Essential Tremor,... (more)

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grace 0 · December 03, 2011 at 1:29 AM

To Hans, It is not that DR.Davis is incorrect but the litmus is that it is VERY RARE at TrackYourPlaque for heart plaque regression. One has to ask WHY?????!! wtf... (more)

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by 353 · October 30, 2014 at 5:01 AM

Extract from a paper: An intuitive explanation for why high cholesterol at an early age might be correlated with Alzheimer's risk has to do with apoE-4. People with that allele are known to have high cholesterol early in life [39], and I... (more)

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Chris_B 0 · February 21, 2014 at 6:12 PM

I have actually thought of the same thing. Could the increase risk of Alzheimer's be due to lowering of the cholesterol through statins and dietary means? There is no corelation between high cholesterol and Alzheimer's but there is one with low... (more)

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by 81 · October 30, 2014 at 3:59 AM

I found my lipid profile from a blood sample taken just before going strict paleo. Here it is compared with my present numbers from 2 days ago (2-1/2 year span): TC = 188 / 372 TG = 89 / 74 HDL = 50 / 73 LDL = 120 / 284 Obviously there is... (more)

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Travis_Culp 0 · March 02, 2012 at 9:16 PM

I hit 393 with heavy butter/cream consumption. I would wager that simply removing that will cause it to plummet, as it did for me. Paleo has created a Healthy Fat monolith that doesn't account for the differential response to various ratios of... (more)

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by 12677 · October 29, 2014 at 3:39 AM

I just came across this interesting study and I'm not sure what to make of it. In a randomized controlled trial, participants were fed either white bread or whole grain sourdough style wheat bread for 6-weeks (the whole wheat contained some other... (more)

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Mscott 0 · July 01, 2012 at 6:52 AM

In case anyone is as curious I am, I have a incredibly speculative hypothesis about this study and decided it would be better to make it an answer. Maybe you've seen Denise Minger's blog post "The China Study, Wheat, and Heart Disease; Oh My!"... (more)

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