Homocysteine and collagen

by (15070) Updated September 26, 2012 at 11:25 PM Created September 05, 2011 at 12:04 AM

Hi, what is the relationship between homocysteine levels and collagen synthesis? Dr Emily Deans wrote about it in her blog and it made me wanna know more. This first paper seems to support her idea that it causes a reduction in collagen while the other one seems to say the opposite. Maybe I don't know enough biochem to know the difference in types of collagen though. Thanks



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6 Replies

1881 · December 04, 2011 at 11:05 PM

Unfiltered coffee raises homocysteine levels. Stress can raise homocysteine levels. Some studies have shown that women's homocysteine levels fluctuate throughout the menstrual cycle. Anxiety before the blood draw is enough to make the level higher than it normally would be. Any so-called high or higher than ideal homocysteine level should be rechecked before a person starts gobbling downs copious amounts of pills to lower it. If it is chronically high, lowering it with bs will not reduce your risk of heart attack. I'm beginning to think too much blood testing and the resultant anxiety may be a risk factor for heart attack...

77338 · September 25, 2011 at 6:37 PM

It probably reduces collagen levels because homocisteine is elevated in inflammation which destroys collagen as collateral damage. B vitamins are typically used with CVD patients to reduce level of HC. If you wish to improve collagen strength, your best bet for now is vitamin C and lysine.

20 · September 11, 2011 at 4:35 PM

Homocysteine can be really reduced by B vitamins. Homocysteine is converted to metionine by folate. To folate work there B12 is needed. For homocysteine to be converted to cystatione and cystatione degraded B6 is needed. Some enzymes there also need B2. When you give B vitamins these enzymes= molecular macchines start to work more. This is the point.

1881 · December 07, 2011 at 4:10 PM

@ Namby Pamby,

Re: coffee -- google it -- many theories abound. It's a your mileage may vary thing as for how you respond to coffee in general and unfiltered coffee specifically. I hope my unfiltered coffee comment doesn't get people trading in their walnut Halloween costumes (fear of omega-6) for espresso cup Halloween costumes (fear of terpenes). That wasn't my intention and all of this coffee talk has me jonesing for a double espresso. Re: why lowering homocysteine via gobbling gargantuan amounts of b vites doesn't lower cvd? -- maybe because homocysteine quite possibly has nothing to do with cvd and McCully's theory was/is wrong. Maybe so called elevated homocysteine means different things in different people and/or in people of different sexes and/or in people undergoing various stress. Association is not causation and the idea that owering homocysteine via b vites would lower cvd did not pan out. Don't believe me -- google it. I would blame chronic stress as a big factor in cvd and would recommend those worried about cvd invest in practicing daily meditation instead of worrying about how to lower homocysteine levels. That's it, I am going for that double espresso...

1213 · September 26, 2012 at 11:25 PM

If lowering homocysteine with B vitamins doesn't reduce the risk of cardiovascular disease, then how the hell does higher homocysteine levels cause heart disease? That doesn't make any sense.

5100 · September 05, 2011 at 1:52 AM

I read that blog too. What I don't understand is her claim that homocysteine levels can be lowered by taking B vitamins. My understanding is that that's not the case.

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