00617208f2e481c293a2f8ad4d097911
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High Progesterone & Estradiol in Male. Causes & Cures?

by (295)
Updated about 9 hours ago
Created April 02, 2011 at 6:06 PM

I've done an adrenal fatigue salivary test. And my results have shown some issues with Cortisol and melatonin. However, the biggest problem was salivary Estradiol and Progesterone which were way above recommended levels (8.1 PG/ml, 213 PG/ml).

I have tried looking for an answer online, but I haven't found anything useful so far. Any clues as to what the cause of this could be? And what to do about it?

I've been strict paleo for 2 years now, lean and fit. I decided to do the adrenal stress test since I've been having issues with managing my stress lately. This, I believe, has led me to gain abdominal fat, decrease my sleep quality (I wake up tired), and decrease my overall energy and mood levels.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 5:08 PM

Higher at night is not good. That is when it should lowest. You need to add a ten min high intensity workout in four days a week and add melatonin and Mg to your nightly regime. That should help lower the night time cortisol....also avoid alcohol and coffee and teas past five pm

9dd74d3941535d0aaa2c8d3cf454fb7e
800 · April 03, 2011 at 4:45 PM

While true that higher DHEA levels favor higher 5a reductase activity, the converse is not true - high levels of DHEA do not rule out 5AR2 deficiency. At any rate, far too much extrapolation from a single salivary hormone test.

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:40 PM

Thanks Dr K! I'm glad you're enjoying this! At least someone benefits from it ;) Here are a few comments: -The test doesn't say if it's E1-2-3. -My cortisol is a litter lower at noon, and slightly higher at night than the recommended range. Nothing dramatic. But since the test was only done on 1 day, it's not necessarily representative. -What's PSA? -What type of doctor you recommend I visit? And what other tests?

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:38 PM

Yea, I've read the list, but since I've been paleo for 2 years now, eating unprocessed clean foods, organic when possible, etc. I think I'm in a way better position than your average person.

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:33 PM

No, my DHEA is closer to the recommended upper limit (8.59 ng/ml). I'm not sure what PSA is? and Yes, mood gets low sometimes!

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:31 PM

Nope, I'm 22 yr old

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:28 PM

No, my DHEA is closer to the recommended upper limit (8.59 ng/ml). I'm not sure what PSA is?

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:27 AM

Thanks for posting this thread......it clearly has stimulated my cortex. I think my teleomeres lengthened just thinking about the raminifications and machinations.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:26 AM

the most common reason still to me.....wthout seeing and doing more labs is adrenal fatigue. I bet your cortisol is the driver. Its the most common reason progesterone is raised.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:25 AM

read masterjohns blog on choline. This whole thread has really spurred me to write a blog. It is precisely why Panu paleo 2.0 will be an epic failure. Science is never that simple......and the answer lies in epigenetics. I know that sounds cryptic but its not meant too.....someday soon and it wont be long yall will get where i am coming from.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:23 AM

age management doc or an endocrinologist......you have had a great effect on me.....tonight i opened a few books because of this post. I want you to get your iodone level checked. You could have a severe iodine deficientcy that is shunting E1 to E3.....(rare) or a choline deficiency that is leading to methylation problem in the methyl shunt......that would be shown by a high homocysteine level too. Still would check you PSA and prostate.....but you are an interesting case for a doc like me. I cant stop thinking about this clinical scenario because there is a multitude of reasons.

Ef4c5b09fdccf73be575d3a0c267fdd9
2544 · April 03, 2011 at 12:52 AM

Dr K... just wondering what kind of help a doctor could give on this outside of hormone replacement...

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 02, 2011 at 11:23 PM

If this were true DHEA would also be low.....check the psa too. Your doc should know to do this as well with elevated progesterone

9dd74d3941535d0aaa2c8d3cf454fb7e
800 · April 02, 2011 at 9:10 PM

Ever take steroids, or anything for hair loss?

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3 Answers

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Ed71ab1c75c6a9bd217a599db0a3e117
1
25467 · April 02, 2011 at 7:32 PM

Few issues here......the estrogen being up.....is it E1 E2 or E3? My bet its E2. And it could be because of aromatase induction. The progesterone elevation could be from several issues. Low T, real low DHT, or it could be from transient BPH. High progesterone in males is associated with low sex drive, bad sleep (low melatonin), shrinking manhood, and elevated BP. This really needs to be sorted out by a doc. You need to see one. Progesterone and cortisol elevation in men are very common things we see.........so don't fret get a consult. Good Luck

Ef4c5b09fdccf73be575d3a0c267fdd9
2544 · April 03, 2011 at 12:52 AM

Dr K... just wondering what kind of help a doctor could give on this outside of hormone replacement...

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:23 AM

age management doc or an endocrinologist......you have had a great effect on me.....tonight i opened a few books because of this post. I want you to get your iodone level checked. You could have a severe iodine deficientcy that is shunting E1 to E3.....(rare) or a choline deficiency that is leading to methylation problem in the methyl shunt......that would be shown by a high homocysteine level too. Still would check you PSA and prostate.....but you are an interesting case for a doc like me. I cant stop thinking about this clinical scenario because there is a multitude of reasons.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 5:08 PM

Higher at night is not good. That is when it should lowest. You need to add a ten min high intensity workout in four days a week and add melatonin and Mg to your nightly regime. That should help lower the night time cortisol....also avoid alcohol and coffee and teas past five pm

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:26 AM

the most common reason still to me.....wthout seeing and doing more labs is adrenal fatigue. I bet your cortisol is the driver. Its the most common reason progesterone is raised.

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:40 PM

Thanks Dr K! I'm glad you're enjoying this! At least someone benefits from it ;) Here are a few comments: -The test doesn't say if it's E1-2-3. -My cortisol is a litter lower at noon, and slightly higher at night than the recommended range. Nothing dramatic. But since the test was only done on 1 day, it's not necessarily representative. -What's PSA? -What type of doctor you recommend I visit? And what other tests?

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:27 AM

Thanks for posting this thread......it clearly has stimulated my cortex. I think my teleomeres lengthened just thinking about the raminifications and machinations.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 03, 2011 at 3:25 AM

read masterjohns blog on choline. This whole thread has really spurred me to write a blog. It is precisely why Panu paleo 2.0 will be an epic failure. Science is never that simple......and the answer lies in epigenetics. I know that sounds cryptic but its not meant too.....someday soon and it wont be long yall will get where i am coming from.

4b97e3bb2ee4a9588783f5d56d687da1
0
22913 · April 02, 2011 at 11:11 PM

Avoid phytoestrogen rich foods. A quick google search will list them for you. I bet you're eating more than one. Also reference the jack my testosterone thread I detailed the food TO eat and why.

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:38 PM

Yea, I've read the list, but since I've been paleo for 2 years now, eating unprocessed clean foods, organic when possible, etc. I think I'm in a way better position than your average person.

9dd74d3941535d0aaa2c8d3cf454fb7e
0
800 · April 02, 2011 at 9:20 PM

The accuracy of salivary hormone testing is debatable: http://www.aetna.com/cpb/medical/data/600_699/0608.html

[QUOTE]  Aetna considers salivary tests of dehydroepiandrosterone (DHEA), estrogen, melatonin, progesterone, or testosterone experimental and investigational for the screening, diagnosis, or monitoring of menopause or diseases related to aging, or any other indications because these tests have not been proven to be valid alternatives to serum tests.
[/QUOTE]

That said, if you confirm high progesterone via serum hormone testing, that can indicate a deficit in the 5a reductase type 2 isoenzyme, which is responsible for transforming progesterone into the neurosteroid allopregnanolone. Are you depressed at all?

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:28 PM

No, my DHEA is closer to the recommended upper limit (8.59 ng/ml). I'm not sure what PSA is?

9dd74d3941535d0aaa2c8d3cf454fb7e
800 · April 03, 2011 at 4:45 PM

While true that higher DHEA levels favor higher 5a reductase activity, the converse is not true - high levels of DHEA do not rule out 5AR2 deficiency. At any rate, far too much extrapolation from a single salivary hormone test.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · April 02, 2011 at 11:23 PM

If this were true DHEA would also be low.....check the psa too. Your doc should know to do this as well with elevated progesterone

00617208f2e481c293a2f8ad4d097911
295 · April 03, 2011 at 2:33 PM

No, my DHEA is closer to the recommended upper limit (8.59 ng/ml). I'm not sure what PSA is? and Yes, mood gets low sometimes!

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