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What are the best supplements to take to reduce inflammation in the brain and fix the gut-brain axis?

by (2565)
Updated about 4 hours ago
Created November 03, 2011 at 6:42 PM

Recently I read that you can do everything to heal the gut and balance the gut bacteria but it won't help if you have a messed up gut-brain axis. The way it was explained is that inflammation from the gut spreads to the brain and disrupts the signals between neurons, particularly between the cortex and the vagus nerve. We need the vagus nerve to be working properly because it is needed for digestion and the inflammatory reflex that controls inflammation in the gut and thus it ends up being a vicious cycle. I've tried everything possible to restore my levels of good bacteria and heal my gut with no success, so I believe I have a problem with my gut-brain axis. I was wondering if there's any supplement(s) that specifically allow the vagus nerve to work properly and heal the blood brain barrier.

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505 · July 28, 2012 at 3:11 PM

Chris, would love to hear an update from you, which supplements/food choices did you make for this issue and have you been successful? I too am trying to support my hypothalamus and brain but am not finding a lot of info to help decide what to do. Thanks!

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2565 · November 06, 2011 at 11:30 PM

The reason I asked about supplements is because I read that inflammation due to dysbiosis/leaky gut travels to the brain and damages the BBB, in effect causing you to have a "leaky brain". I read that omega 6s are probably the biggest factor besides inflammation from other sources in affecting the bbb so you're right about that. I'm working on lowering my BG so hopefully that will help me, but I still seem to have lots of inflammation.

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11478 · November 06, 2011 at 11:24 PM

@Dr G, please put that information on your profile, along with your name. You can't post anonymously as a health care provider on PaleoHacks.

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2565 · November 06, 2011 at 11:18 PM

Yea I agree, there are exceptions to getting everything from food, but it's best to minimize them. My brother said there's kelp powder you can buy, would that have more fucoidans in it since it's more concentrated than whole kelp?

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25467 · November 06, 2011 at 10:54 PM

no supplements do this well. To improve the BBB one must eliminate omega sixes in diet and limit the amount of glucose in the blood by uptaking it in your muscles quickly. The more fit you are the better your muscle utilization is. High levels of BG also block LDL endocytosis at the BBB and this is a big problem in AD and many neurodegenerative disorders.

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78422 · November 06, 2011 at 9:06 PM

I'm a chiropractor class 81 palmer college Davenport Iowa

6426d61a13689f8f651164b10f121d64
11478 · November 06, 2011 at 3:38 PM

Dr G, please provide a link to your credentials or remove the "Dr" from your moniker (see the FAQ for the policy on anonymous health care providers). Otherwise, your account will be deleted. Thanks,

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:08 AM

who needs your opinion? i saw some of your answers, next time don't steal your kid's homework.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:08 AM

who needs your opinion, geezer? i saw some of your answers, next time don't steal your kid's homework.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:06 AM

who needs your opinion, geezer? i saw some of your answers, next time don't steal your kids's homework.

B91162c65eab8082b414048a30759a77
2565 · November 06, 2011 at 3:05 AM

Well I'm pretty ocd so I over think everything, it's a gift and a curse. I was focusing more on inflammation with this question since I know I have too much of it. But I obsess even more with my health since I've been without it for so long. I have the following symptoms: -constant gut pain and bloating -very low appetite -low energy -constipation -food allergies. There's more but those are the main ones pertaining to the gut.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:00 AM

sadly for you, there's no cure for rudeness.

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45 · November 06, 2011 at 2:34 AM

As for the leaky gut syndrome question, I'm afraid that'll have to wait for another day...my nurses are calling me to come back because Kim Kardashian's massive butt apparently need a forklift and a bulldozer to get the job done. Good luck and....you're welcome. ;)

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45 · November 06, 2011 at 2:32 AM

In other words when free radicals go to destroy body tissue, glutathione will absorb the hit instead, sparing tissue and minimizing destruction. It then gets recycled so it is ready for action again. There's a formulated product in the market called Glutathione Recycler by Apex Energetics that not only boosts glutathione levels, but also keep levels of glutathione in the body and brain high through recycling. Together with Oxicell these products can powerfully boost your brain’s ability to tame inflammation and protect vital brain tissue.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 2:31 AM

i see you have come for more professional advice. lucky for you, i've just came out of the ER from operating on Kim Kardashian's butt to update my fb status and decided to hit two birds in one stone..so i'll give you your answer. It's pretty simple actually.. Glutathione is our most powerful antioxidant and Oxicell is a way to really boost glutathione levels and also quench inflammation. However in a stressed system levels can become quickly depleted, even if you supplement. Glutathione recycles through different forms, “taking the bullet” to protect your body’s cells.

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2565 · November 06, 2011 at 2:24 AM

In your professional opinion then, what are the causes of leaky gut syndrome and how does glutathione recycling control inflammation?

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45 · November 06, 2011 at 2:11 AM

how's your ginger candy? are you running out of it? tell jon i'm a doctor now!:P

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45 · November 06, 2011 at 2:06 AM

no problem babe ;)

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2565 · November 06, 2011 at 2:05 AM

I agree with your assessment, because I have food allergies as well and constant gut pain. You're right about the lack of an off switch in the brain, I recently heard on chris kresser's podcast that the microglia in the brain are activated from inflammation from the gut and don't have an off switch so they keep inflaming the brain til the inflammation from the gut is stopped. I'll def research the product you recommended though, thanks for the advice.

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2565 · November 06, 2011 at 1:40 AM

I don't have rashes or sinus problems, but I have really bad brain fog every day and am very drowsy as well.

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2565 · November 04, 2011 at 7:42 PM

Thanks Dr. G, I'm very interested in your answer. I've heard of fucoidan but haven't researched it, but it sounds like just the thing I need since it reduces inflammation and stimulates the immune system. Adriana, you can get it from food, just buy kelp at the grocery store. Actually the one near me has kelp powder which is more concentrated so you don't need to eat a lot of kelp to get the benefits of fucoidan.

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1059 · November 04, 2011 at 3:02 PM

Oh no, not another supplement? Can't we just get it from food?

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1196 · November 03, 2011 at 8:59 PM

This is interesting! But how do the suboccipital muscles influence the vagus nerve? Aren't they on different sides of the neck?

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1054 · November 03, 2011 at 7:44 PM

For brain/gut http://bit.ly/vAxbnL For Leaky Gut http://bit.ly/mZt8Dc

Ba5b05f5c84750734b218e9f482103dc
138 · November 03, 2011 at 7:12 PM

Lots of new research going on with Leaky Gut Syndrome and Autoimmune disorders.

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10 Answers

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78422 · November 04, 2011 at 5:06 AM

Try 7:1 concentrated yacon syrup as a powerful prebiotic to go with you acidophillus/bifidus cultures also try fucoidan - a long chain polysaccharide from several species of kelp - they act better than the new class of antiinflammatories and help stem cells get to the areas needed for repair. see the research about fucoidan at bottom of page on this link - it links thru to the aussi biotech co that just patented clean extraction methods for getting fucoidan from seaweed - its the component thought to be responsible in part for the okinawan phenomena - most people over 100 who are still active.http://www.matakanasuperfoods.com/ms/products/fucoidan.html

also cut down on omega six sources as excess omega six tissue saturation promotes inflammation nothing will help in some instances until that is fixed. ancient ratio was 1 omega 3 to 3 omega six - now more like 1/30 which undermines the whole physiology and sets up an underlying unexplaned inflammation

2b2c2e4aa87e9aa4c99cae48e980f70d
1059 · November 04, 2011 at 3:02 PM

Oh no, not another supplement? Can't we just get it from food?

B91162c65eab8082b414048a30759a77
2565 · November 04, 2011 at 7:42 PM

Thanks Dr. G, I'm very interested in your answer. I've heard of fucoidan but haven't researched it, but it sounds like just the thing I need since it reduces inflammation and stimulates the immune system. Adriana, you can get it from food, just buy kelp at the grocery store. Actually the one near me has kelp powder which is more concentrated so you don't need to eat a lot of kelp to get the benefits of fucoidan.

77877f762c40637911396daa19b53094
78422 · November 06, 2011 at 9:06 PM

I'm a chiropractor class 81 palmer college Davenport Iowa

6426d61a13689f8f651164b10f121d64
11478 · November 06, 2011 at 3:38 PM

Dr G, please provide a link to your credentials or remove the "Dr" from your moniker (see the FAQ for the policy on anonymous health care providers). Otherwise, your account will be deleted. Thanks,

6426d61a13689f8f651164b10f121d64
11478 · November 06, 2011 at 11:24 PM

@Dr G, please put that information on your profile, along with your name. You can't post anonymously as a health care provider on PaleoHacks.

E40b2fc9ddcf702bab9d61d28b8c8440
505 · July 28, 2012 at 3:11 PM

Chris, would love to hear an update from you, which supplements/food choices did you make for this issue and have you been successful? I too am trying to support my hypothalamus and brain but am not finding a lot of info to help decide what to do. Thanks!

Ba5b05f5c84750734b218e9f482103dc
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138 · November 03, 2011 at 7:09 PM

Check out chriskresser.com. He just posted a podcast about gut health that I haven't heard yet but I've listened to other podcasts and he has some great stuff. And I've heard good things about Coconut oil and brain health. Also Bodyecology.com talks a lot about brain/gut health.

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78422 · November 03, 2011 at 8:10 PM

A constant them of mine has been and always will be ,that in additon to a physiological basis of disease there will alway be an equal (more or less) anatomical basis of dysfunction. Influence the vagus nerve by treating the suboccipital muscles. Dig into them with a finger or knuckle. You'll find them to be soar. Keep digging until it lossens up. Or find a good neuromuscular therapist in you area. A huge chunk of stomach distress can be resolved in minutes under the properly trained thumb. The same therapist should know how to preform visceral manipulation as well.This will help relieve another large chunk. Try it, you'll like it...... If you correct the anatomic issue then the metabolic intervention will work much beter (factor of 2-10!) . Then try accupucture. Find a local community accupuncturist (around $20 /visit.)

792634a784ec6a636c3137d0903e11b4
1196 · November 03, 2011 at 8:59 PM

This is interesting! But how do the suboccipital muscles influence the vagus nerve? Aren't they on different sides of the neck?

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3742 · November 03, 2011 at 7:04 PM

Ugh... tell me about it. I have idiopathic Gastroparesis with a noisy EGG. I don't know about spreading inflammation but there are some autoimmune conditions which can develop from poor diet which aren't commonly known. Mayo Clinic has a panel that you can order called the Autoimmune Gastric Dysmotility panel to help here. Your doctor probably hasn't heard of it nor does he know what to do with the results and you're not going to travel to Mayo clinic unless you're really sick but it might be enlightening.

The Vagus nerve also controls a number of other important functions by the way so you can determine if it is defective by looking at them. A good starting point would be your heart rate. Get an overnight oximeter and see what your heart rate looks like while you're sleeping. It should look like smooth hills with the occasional spike from your dreams. Mine looks like a Seismograph from an earthquake.

Ba5b05f5c84750734b218e9f482103dc
138 · November 03, 2011 at 7:12 PM

Lots of new research going on with Leaky Gut Syndrome and Autoimmune disorders.

5d2defc09dc03ab5b339f5874738421c
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45 · November 06, 2011 at 1:56 AM

i'm positive you have leaky gut syndrome. The brain???s immune system is different than the body???s. The body???s immune system has the ability to turn on and off, whereas the brain???s immune system does not have an off-switch. This means unmitigated inflammation destroys plenty of brain tissue. So what you might want to do is to tame the brain inflammation. NeuroFlam contains a number of botanicals that have been shown repeatedly in studies to quench the brain???s runaway inflammation. Glutathione recycling and nitric oxide modulation are two powerful new ways to modulate out-of-control brain inflammation and bring symptom relief from many common neurological problems today. Good luck.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 2:31 AM

i see you have come for more professional advice. lucky for you, i've just came out of the ER from operating on Kim Kardashian's butt to update my fb status and decided to hit two birds in one stone..so i'll give you your answer. It's pretty simple actually.. Glutathione is our most powerful antioxidant and Oxicell is a way to really boost glutathione levels and also quench inflammation. However in a stressed system levels can become quickly depleted, even if you supplement. Glutathione recycles through different forms, “taking the bullet” to protect your body’s cells.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 2:34 AM

As for the leaky gut syndrome question, I'm afraid that'll have to wait for another day...my nurses are calling me to come back because Kim Kardashian's massive butt apparently need a forklift and a bulldozer to get the job done. Good luck and....you're welcome. ;)

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 2:11 AM

how's your ginger candy? are you running out of it? tell jon i'm a doctor now!:P

B91162c65eab8082b414048a30759a77
2565 · November 06, 2011 at 2:05 AM

I agree with your assessment, because I have food allergies as well and constant gut pain. You're right about the lack of an off switch in the brain, I recently heard on chris kresser's podcast that the microglia in the brain are activated from inflammation from the gut and don't have an off switch so they keep inflaming the brain til the inflammation from the gut is stopped. I'll def research the product you recommended though, thanks for the advice.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 2:06 AM

no problem babe ;)

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 2:32 AM

In other words when free radicals go to destroy body tissue, glutathione will absorb the hit instead, sparing tissue and minimizing destruction. It then gets recycled so it is ready for action again. There's a formulated product in the market called Glutathione Recycler by Apex Energetics that not only boosts glutathione levels, but also keep levels of glutathione in the body and brain high through recycling. Together with Oxicell these products can powerfully boost your brain’s ability to tame inflammation and protect vital brain tissue.

B91162c65eab8082b414048a30759a77
2565 · November 06, 2011 at 2:24 AM

In your professional opinion then, what are the causes of leaky gut syndrome and how does glutathione recycling control inflammation?

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40 · May 31, 2013 at 8:23 PM

craniasacral therapy by a physician.. they can focus on vagal nerve. perhaps acupuntcure with a master. By the by glutathione is useless to me I was genetically tested and my body does not have the liver phase 2 glutathione pathway.. so I do the glutathione precursers. one thing that seems to work is a combination of onion garlic and hot peppers. curcumin is good and cayenne help inflammation. But why is the body throwing up inflammation in the first place.. that is the question.. Brain Gut- Gut Brain Axis absolutely. I had a head trauma first though and then the leaky gut diagnoses 6 years later. I am still trying things to heal my intestinal permeability as well as my self diagnosed leaky brain barrier ( two MDS think I am correct on this but I wont do the myelogram too risky I think). I have been approaching from a heal the gut aspect but not helping so much ( I understand it takes a few years with aggressive approach I am only on year 1 ), hence I am thinking of listening to my NASA doc and approaching it from the brain aspect with lipid replacement therapy etc. What is interesting is doctors have figured out how to open up the blood brain barrier for medical treatment. Dr Bryzenski in TX treats aggressive brain tumours with a large rate of success using his lab developed human amino acid combination ( 18 acids I believe ). Also I have found is folks with leaky brain have a specific diet that says ingest no amino acids, walnuts etc as they compromise blood brain barrier. I have found this to be true for me. One person healed themselves of water on the brain with doses of wheat grass throughout day plus potassium chloride. seaweed is high potassium... hmmm what builds the BBB? nanoparticles photon memory stem cell .. so many things forthcoming. And if I get a customized microbiome prescript as Johns Hopkins researcher says is forthcoming will that help the brain?

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2936 · November 07, 2011 at 12:55 AM

Turmeric gets into all the nooks and cranials, doesn't it? It's anti-inflammatory.

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78422 · November 06, 2011 at 9:10 PM

The fucoidans i mentioned only come from several species of seaweed - not all - and you have to eat a heck of a lot of it regularly to get the amt the okinawans traditionally had in there diets - i dont usually suggest anything but whole food - just cant see most people getting that volumne of seaweed down - but yes i agree fresh and whole is just about always best.

B91162c65eab8082b414048a30759a77
2565 · November 06, 2011 at 11:18 PM

Yea I agree, there are exceptions to getting everything from food, but it's best to minimize them. My brother said there's kelp powder you can buy, would that have more fucoidans in it since it's more concentrated than whole kelp?

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45 · November 06, 2011 at 1:23 AM

before i give you my professional advice..first, there are questions i want to ask: do you experience sinus complications and do you experience rashes on any part of your body, brain fog and drowsiness?

B91162c65eab8082b414048a30759a77
2565 · November 06, 2011 at 1:40 AM

I don't have rashes or sinus problems, but I have really bad brain fog every day and am very drowsy as well.

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8239 · November 06, 2011 at 2:51 AM

What else in your life are you over-thinking, besides the subject about which you write?

Please give specific info about the state of your "gut" if you want serious responses.

B91162c65eab8082b414048a30759a77
2565 · November 06, 2011 at 3:05 AM

Well I'm pretty ocd so I over think everything, it's a gift and a curse. I was focusing more on inflammation with this question since I know I have too much of it. But I obsess even more with my health since I've been without it for so long. I have the following symptoms: -constant gut pain and bloating -very low appetite -low energy -constipation -food allergies. There's more but those are the main ones pertaining to the gut.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:08 AM

who needs your opinion? i saw some of your answers, next time don't steal your kid's homework.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:06 AM

who needs your opinion, geezer? i saw some of your answers, next time don't steal your kids's homework.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:00 AM

sadly for you, there's no cure for rudeness.

5d2defc09dc03ab5b339f5874738421c
45 · November 06, 2011 at 3:08 AM

who needs your opinion, geezer? i saw some of your answers, next time don't steal your kid's homework.

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