most recent 30 from http://paleohacks.com 2013-05-25T03:26:17Z http://paleohacks.com/feeds/question/71878 http://www.creativecommons.org/licenses/by-nc/2.5/rdf http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin RaspberryCoconut 2011-10-21T12:45:05Z 2013-03-05T09:49:08Z

<p>I'm about to embark headfirst into Dr. K's leptin reset due to the fact that I've been steadily gaining weight and exhibit many of the LR symptoms. I have PCOS and am probably insulin resistant. My basic take on the leptin reset is that if you correct the LR the IR will follow. I'm currently taking low-dose Metformin (500 mg) and I'm wondering if this will interfere with my body resetting itself. Should I hold off or take it at a specific time?</p> <p>A little background info- 25 y/o female, PCOS, 142 lb, was happily at 125 for a while then went on birth control to "cure" my amenorrhea, packed on 15 lbs in 2 months and have not been able to lose it. Amenorrhea returned after I quit the pill, my doctor put me on Metformin in attempt to manage PCOS. I might as well be taking a placebo, I notice no difference.</p>

http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin/75248#75248 Jeff 2011-11-06T15:52:14Z 2011-11-06T15:52:14Z

<p>The article was good but pretty vague about how it worked. It originated from phytonutrients in french lilac. From my understanding, aside from increasing insulin sensitivity, it also </p> <ul> <li><p>causes a decrease in hepatic glucose production via gluconeogenesis, </p></li> <li><p>increases peripheral (ex skeletal muscle) utilization of glucose, </p></li> <li><p>appears to increase the translocation of GLUT transporters to the cell surface</p></li> </ul> <p>It leads to AMPK activation which is associated with inhibition of lipogenesis because it inactivates acetyl CoA carboxylase (ACC) and suppresses lipogenic enzyme expression. AMPK activation is also required to suppress glucose production in hepatocytes.</p> <p>This relates closely to Dan Atkinson's theory of Adenylate energy charge</p> <p><a href="http://pubs.acs.org/doi/abs/10.1021/bi00851a033" rel="nofollow">http://pubs.acs.org/doi/abs/10.1021/bi00851a033</a></p>

http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin/75257#75257 RolandPlain 2011-11-06T17:05:46Z 2011-11-06T17:05:46Z

<p>*Neoglucogenesis</p>

http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin/75480#75480 Paleo4ever 2011-11-07T17:41:09Z 2011-11-07T17:41:09Z

<p>Raspberry....I am in a very similar situation as you...PCOS constantly gaining...I am trying to the Leptin Reset as well...Could you share your progress and routine...ie. what you eat...at what time...and what you have noticed so far?</p> <p>Thanks!</p>

http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin/75495#75495 Happy Now 2011-11-07T19:26:20Z 2011-11-07T19:26:20Z

<p>If you are concerned, you could swap out NAC (N-Acetyl-Cysteine) for your Metformin. I have no idea what effect Metformin will have on the Leptin Reset, but for women with PCOS, NAC outperformed Metformin and didn't have the side effects or price tag.</p> <p><a href="http://www.ovarian-cysts-pcos.com/pcos-news140.html#sec1" rel="nofollow">http://www.ovarian-cysts-pcos.com/pcos-news140.html#sec1</a></p>

http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin/129384#129384 Crowlover 2012-06-21T02:19:23Z 2012-06-21T02:19:23Z

<p>How are you doing on the Metformin? Im considering it myself. Would be great to hear some followup. Im unclear how to ask for that other than in this Answer box. I understand this is a question not an Answer :)</p> <p>If anyone has advice on how to ask for follow up in a better way... Im all ears.<br> Thank you. </p>

http://paleohacks.com/questions/71878/dr-ks-leptin-reset-and-metformin/183352#183352 Danielle 2013-03-05T09:49:08Z 2013-03-05T09:49:08Z

<p>I'm in a similar boat 142, and doing the LRP with PCOS. Ive been doing it for 3 weeks now and had one day last week where I didnt stick to the protocol so I guess I am back where I started. I haven't lost any weight yet - but I haven't gained so I guess that's better than nothing....</p>