User the quilt - PaleoHacks.com

Answer by The Quilt for 11 Weeks Paleo, and NOW I have sudden onset of joint pain...

2013-05-15T12:05:54Z

Here is an excerpt from a blog I wrote that may help you understand why this happens.

"Another byproduct is acetaldehyde and it is related to formaldehyde this disrupts collagen production, fatty acid oxidation and blocks normal nerve functions. I see this problem as a spine surgeon because of the acceleration of disc degeneration in the spine. Orthopedic surgeons see it in the major joints. We are taught to replace those joints instead of fixing the real problem…….the altered gut. I got this message about 7 years ago and began to change the way I managed the diseases of the spine and brain. The ethanol and acetaldehyde will also help hasten the brain by allowing more inflammation into through the blood brain barrier and into the brain. When this occurs we see depression, the loss of DHA (fish oil fat), phospholipids, ceremides and sphingolipids in the brain and function slowly diminishes overtime. Protein folding becomes abnormal and things like Alzheimer’s, and Parkinson’s, and cerebral strokes become very common. When we lose DHA we tend to replace it with other PUFA’s that don’t have the “magic built” into its chemistry that DHA does. We outlined that briefly in Brain Gut 5. That was a pretty important blog post in retrospect. We also lose total body and brain iodine that protects our DHA from any oxidative attack. This diminishes the production of pro-resolution chemicals in the brain. They are called resolvins, lipoxins, and protectins. I mentioned these briefly in Brain Gut 5. They were discovered by an opthalmic researcher at LSU (Dr. Bazan) and this is where I first heard about them. Their job is to protect the most sensitive part of DHA’s PUFA structure from the oxidation of inflammation. They work in concert with iodine to protect the integrity in the areas of the synapse where nerve connections are made. This is where neural connections occur to control all the processes in our body. This allows us to control proper signaling. This is the source of all cancers. When inflammation is high signaling is lost in all types of neolithic diseases. Most diseases have an inflammatory brain component to them."

http://www.jackkruse.com/brain-gut-9-what-really-killed-michael-jackson/

Answer by The Quilt for Neuropathy, Raynaud's, or pinched nerve, pinched artery, or detox?

2013-05-14T16:18:36Z

points to altered omega 6, trans fats, and fluoride embedded in your neurons cell membranes........cold will change this because it forces neuronal cell membrane turnover when you are eating omega 3's. Trans fats, fluoride and certain omega 6's act as dielectric blockers for cell membranes. I covered this is my EMF 8 blog post and on the second page of the Cold Thermogenesis 2 blog. It is contained in this article. Google it: Changes in ‘Good’ Fatty Acid Concentration of Inner Organs Might Be Largely Independent of Diet.

Answer by The Quilt for Taste buds are off - plain water tastes sweet! Why?

2013-05-14T15:07:36Z

Water is critical to this........but what your status is lab wise and physiology wise is really germaine to this question. Sweetness is tied to fluoride blockade of the taste bud neural pathways in the nucleus tractus solitarius. When taste is off it tells you something is off in physiologically in your brain's energy transfer pathways. Specifically, in two specific semi conducting doping ions in the body used in neurons......Zn and copper. I would not jump to carbs.......until you know precisely where you are now metabolically and physiologically. Some of the info in these blogs will help you. I talk about the copper doping mechanism used in bone here: http://www.jackkruse.com/emf-8-quantum-bone/

1.http://www.jackkruse.com/quantum-biology-3-queer-water/

2.http://www.jackkruse.com/quantum-biology-4-coherent-water/

3.http://www.jackkruse.com/emf-4-why-might-you-need-carbs-for-performance/

4.http://www.jackkruse.com/quantum-biology-2-quantum-pcos/

Good Luck in your search........for answers.

Answer by The Quilt for DHA and EPA how much do we need

2013-05-06T01:17:02Z

http://www.jackkruse.com/brain-gut-5-paradigm-drifts-paradigm-shifts-epi-paleo/

Answer by The Quilt for Anybody Diagnoise with PCOS Doing Crossfit and Prescribed Metformin?

2013-05-06T01:14:36Z

http://www.jackkruse.com/quantum-biology-2-quantum-pcos/

Metformin helps but it depletes you chronically of Mg and water so you must know it when using it and replace it aggressively. You'd be wise to stop cross fit. Your fertility is trying to tell you something. We all have a doctor inside of us, but the real question is do we listen to that voice?

You must ask and answer that for you now.

Answer by The Quilt for hypothyroidism and weight loss

2013-05-02T03:00:59Z

1.http://www.jackkruse.com/emf-2-einstein-meet-leptin/ 2.http://www.jackkruse.com/cold-thermogenesis-7/ 3.http://www.jackkruse.com/brain-gut-11-is-technology-your-achilles-heel/

Answer by The Quilt for Thinking about moving; suggestions?

2013-05-02T02:57:42Z

http://www.jackkruse.com/does-where-you-live-actually-matter/

Are you an introvert or an extrovert?

2011-06-26T03:50:24Z

Do you think a paleo diet selects for one or the other?

http://www.carlkingcreative.com/10-myths-about-introverts

Answer by The Quilt for Trying to lose weight and get healthier, looking for advice.

2013-04-03T11:47:55Z

http://www.jackkruse.com/easy-start-guide/

Answer by The Quilt for Body Fat Loss Help

2013-04-03T11:46:33Z

http://www.jackkruse.com/easy-start-guide/

Answer by The Quilt for Daily water intake?

2013-04-03T11:45:12Z

http://www.jackkruse.com/quantum-biology-3-queer-water/

Answer by The Quilt for Calorie Restriction: The Original Ketogenic Diet.

2013-03-31T14:43:58Z

An excerpt:That answer maybe buried in the bio-energenic literature I reviewed while a resident at LSU for brain energy transport. I recalled reading about the effects of the ketogenic diet on pediatric brain tumor patients and on patients with neurodegenerative disorders in the mid 1990s. I had to put together a talk on this back in 1995. When I got home I opened up some books and Pubmed searched a bit. I think that nap might have been what I have been looking for. Got to love autophagy from sleep! It surely does stimulate neurogenesis so we can learn!

First, let’s talk a little bit about what a ketogenic diet is and what it does for certain peoples’ brains. It is a current mainstream treatment for epilepsy and neurosurgical pathology today but it is rarely used often enough. The reason it is not used is because antiepileptic drugs are now considered first lines of therapy these days. Conventional medicine wisdom exists even in neurology and neurosurgery I am afraid. The treatment actually dates back to the early Greek civilization around 350-400 BC. They used fasting as a way to improve the symptoms of epilepsy. I remember reading back then the reason the treatment often failed is because the patients got quite hungry after a week of this. So it was not a sustainable long term treatment. The medical community re-discovered fasting at the turn of the 20th century in Europe. A study was even undertaken in France to show its efficacy. It showed much promise but again compliance was the rate limiting factor. The idea then traveled across the pond to the USA and several physicians came up with a “modified water diet” that had ten percent food and 90% water as its backbone. The American trials showed promise but again were limited by hunger compliance.

Interestingly enough, one of the patients was boy who father was a rich NYC landlord who donated some money for further research into how this “water diet” actually worked. The money went to Dr. Lennox and Dr. Cobb at Johns Hopkins, who later became famous. From those studies we found out that fasting induced the formation of ketone bodies. All three ketone bodies were found with that grant. Once this occurred the Mayo Clinic researchers joined the party and actually named the diet the “ketogenic diet“. They actually worked out the macronutrient ratios for the diet to be used in 1924. They found children needed one gram of protein per KG of weight, no more than 15 grams of carbohydrates per day, and the rest of dietary calories had to come from fat. Once this was done it was used extensively in children with great success. It met with limited success in adults and interestingly enough, this is why the diet was abandoned and antiepileptic medications became first line drugs back then. This is where my residency recall ended of the papers I had read for my talk. I knew even today that in difficult seizure cases where all medications fail, like Lennox-Gastaut syndrome, that the ketogenic diet is still used. I have used it myself as a neurosurgeon for patients with difficult seizure control who harbor brain tumors.

The diet came back to life while I was in residency because another famous NY TV person had a son who went on the diet and did quite well. They even made a TV show about the child’s case. A multicenter trial was begun and the results released as I was finishing my training in Neurosurgery. Today most epilepsy centers offer ketogenic diets as mainstream therapy for drug resistant seizure disorders. It is even covered by all US insurance carriers as of 2011. Interestingly, the literature is bare with a mechanism of action. I can hear you saying this to me now, Doc, where is this all heading? Why should I care? Well, in the paleo blogosphere there are so many arguments about macro and micronutirents ratios and levels and what is optimal and what is not. There are constant questions to many podcasters asking about metabolic typing and related topics. I think the ketogenic diet firmly answers the question whether or not specific macronutrient levels can have a direct effect on metabolism in a measurable way. Remember most current low carb paleo diets are direct ketogenic diets as well. Here comes your relevance.

The ketogenic diet of today is loaded with MCTs usually from coconut oil. MCT are metabolized quite differently than other fats. The low carb paleo diet is heavily steeped in MCT oils as well. The carb content is usually kept below 100 grams but the range most use is even lower than that. Mind you I don’t advocate this across the board for everyone.

I myself eat a high percentage of calories of fat and protein with copius amounts of non fluoridated hard water based upon my own testing and results. This puts the patient in sustained ketosis and is a successful way to reverse metabolic syndrome and lose weight. But it confers a much bigger advantage that previously has gone unrecognized until now. What is that advantage? OK…….this part is going to hurt your brain because it has a lot of cerebral physiology but I promise the pay off is worth it.

In neurosurgery, we have hundreds of thousands of studies done on the coupling of cerebral blood flow (CBF) to cerebral metabolic rate of oxygen consumption (CMRO2). Neurosurgeons are experts in managing CBF and CMRO2 in neurologic injury or in pathologic states to navigate patients back to health. We spent seven years learning how to alter this simple equation to provide the best outcomes to patients. We need to control CBF often because, if it increases indiscriminately, the patient will die because the brain swells and it is located in a fixed closed compartment. This is commonly how one becomes brain dead in case you are wondering. The brain controls its own CBF by a process called autoregulation. In simple terms, the metabolic activity of the neurons determines how much blood flow a certain region of the brain gets. The only way to uncouple CBF from metabolism and keeping the patient alive is inducing general anesthesia. Uncoupling or losing autoregulatory control does occur in many neurologic diseases. For example , when we do dynamic cerebral blood flow studies in the brain we can tell the difference between patients with Alzheimer’s disease (AD) and vascular dementia by testing their metabolic consumption of oxygen. The difference lies in how the CBF looks in each disease.

In vascular dementia (chronic TIA’s) the problem is a poor blood supply to the neurons. Dehydration robs the brain water and it slows energy production because water is found in the mitochondria and makes up 70% of the brain. This starves the brain slowly of oxygen causing long standing neuronal cell death and leads to a dementia. The neurons are completely normal–just starved for air and water. Autoregulation however is completely intact. In AD, the neurons are diseased from protein folding defects but the blood vessels can deliver a normal cerebral perfusion pressure. Protein folding is a key early problem in all neurodegenerative diseases. This means oxygen flow is intact in the AD patients’ brain.

The neurons however on the dynamic PET/SPECT scans show major hypo-metabolism and hypo-perfusions in the frontal and temporal lobes. Autoregulation is clearly uncoupled in AD and it is 100% tied to a loss of energy. Remember the only way we have to uncouple CBF from CRMO2 and keep the patient alive is anesthetic drugs. This begs the question…when we put a person with AD under a general anesthetic do they react differently since their neurons cannot control their own perfusion do to the formation of neurofibrillary tangles? Anesthesia literature says this is a true statement. So then why is it that a ketogenic diet, high in MCT oils, very helpful in improving cognitive function in AD? Here is where it gets real interesting.

The brain is an amazing organ of evolution. It makes up 2% of our body weight but draws 20% of our cardiac output. This means it is the ultimate energy hog. But one would expect that because of the amount of energy it uses to run the entire human body. Moreover, as humans evolved the neocortex (human parts of our brain) it increased the demand for energy to greater degree than primates. More brain tissue evolved means more oxygen is needed. This is why primates pound for pound are stronger than us. Their lineage chose muscle-skeletal strength to climb trees while we evolved brains to increase our thinking ability. This allowed us to forage for food with more diversity because we could think to find ways to forage better than we had. Forming social networks to use collective knowledge is an example. But this huge evolutionary advantage also came with a cost. A human can live without food for 30 days. They can survive for without water for seven days. But the human brain cannot do without oxygen for 4 minutes or it dies. It is clear water and oxygen are the fuel sources for the brain somehow.

Because of the brain’s high metabolic demands, when humans think or do any mental activity they can only activate about 2% of the total neurons in their brain to carry out the task when they are using glucose as a source of fuel. This has been shown by PET scan studies and more recently in fMRI studies using CRMO2 as the major variable. This limits our ability to use multiple systems at once. If we did we would pass out from the lack of oxygen due to the heightened CRMO2 by the neurons actively engaged. Remember that oxygen consumption in the brain is directly coupled to blood flow. When the human brain is running on a ketogenic diet as its primary source of fuel the ketone bodies directly down regulates genes that allow glucose to be utilized in neurons. Moreover, the ketone bodies allow us to use between 35 ~100% more total neurons than we could with the isocaloric dose of glucose as fuel. This means we can activate and use more neurons using less oxygen! That provides a huge macronutrient advantage for ketosis. It appears that the real advantage of ketosis from the brain’s perspective is an increase function and cognition. This is pretty amazing and in fact has been shown in many patients with neurodegenerative disorders like Alzheimer’s disease.

Remember my original point about how the brain works normally. Neurons determine how much CBF it needs based upon its own metabolic demands. CBF is tightly coupled to CMRO2 given the wide variations in blood pressures. BP is a function of plasma water content. A ketogenic diet works by uncoupling CBF from CMRO2! This means that eating a ketogenic diet allows a higher CBF while have a lower resting cerebral metabolism. Carbohydrates and proteins have never shown this benefit in any study I know of testing cerebral autoregulation. This means that a low carb, high MCT fat diet confers a significant metabolic advantages to the brain. The brain directly controls all efferent and afferent pathways of metabolism via leptin. The implications are big. Remember that food is thought to be our only a substrate source of electrons for our mitochondria’s electron transport chain in organic chemistry terms. This also means that somehow the electrons that come from these ketone bodies affects the neuronal ATP requirement of cerebral mitochondria. Is it possible they come from elesewhere or does the electrons from food have a quantum effect?

This was the essence of the question that I asked “The Kracken” at AHS. I asked him if all electrons are created equal? On the surface this sounds like an “ignorant question” until one thinks about the implications of these findings in the pathologic brain. Something has to allow for this metabolic advantage. So what is it? That is open for debate, but I think i have a solid answer. But this is where the physics papers come in that I was talking to Matt about.

We know experimentally that CMRO2 (cerebral metabolism) is tied directly to microtubule function and mitochondrial ATP production in the brain. The only way we have as neurosurgeons to uncouple neuronal oxygen consumption from cerebral blood flow and not kill neurons is inducing anesthesia. Today we don’t know precisely how anesthesia works, but Stuart Hameroff, MD (an Anesthesiologist at Univ of AZ) believes he does. His work is pretty amazing and I have been reading it for sometime. I just never put metabolism and physics together until today’s trip home. We know that volatile anesthetic gases act by Van deer Waals (London Convention) forces in hydrophobic pockets of select brain proteins to ablate consciousness. It’s called the induction of gamma coherence of neuronal microtubules. The quantum field theory mathematics and physics are quirky, but I think the answer to many unknown biologic forces will come back to Einstein’s core principles he laid out in 1905 and in subsequent papers. Most of you know that quantum mechanics deals with the physics , chemistry and biology at a subatomic particle level. Well, electrons from all types of sources and from foods fit that bill.

The real question is do electrons from different macronutrients have specific quantum biologic effects? Many of the things that have been mathematically predicted by Einstein’s quantum mechanical theory have been proven true by science today. For example, the presence of a black hole, a quasar, or the fact that time bends at the speed of light. When he first made the predictions he was mocked. He predicted a quasar and a black hole in the 20′s and until the Hubble telescope was deployed recently, we did not know for sure. We now know he was correct. Einstein’s mathematics also says that things that are of the same origin always remain connected in some fashion no matter how far apart they may exist in space or in time. This is his theory of non locality. I have been an Einstein freak my whole life. And I have been wondering for 15 years whether an electron from carbs, fat or protein, or somewhere else is somehow categorized differently than one another by metabolism. If so this could have major implications for a new understanding of all the biologic pathways in metabolism and in aging.

I can hear you thinking, I am drinking the woo woo now! No, I can promise you I am not. The reason I have been thinking about gamma coherence and “if” all electrons are really equal is because of this seemingly incongruent experimental effect of the ketogenic diet on brain metabolism. The real data implies something else is behind energy transfer in the brain. It clearly is different in the brain as I have laid out here. So would evolution select the brain about differently than any other organ in our body? I don’t doubt it, because evolutionary biology uses a strict fractal geometrical framework for evolutionary progression. I think the answer is in water. This post likely will stimulate the debate in the blogosphere about the real differences in macronutrients effects upon metabolism. At least, I hope it would.

I’m wondering out loud about how far reaching this effect may reach. But I now have a more complex puzzle to solve. Why does this happen with only a ketogenic diet? Why are carbs and protein afforded no such benefits? This needs to be asked don’t you think? And now you have the essence of what I was trying to ask “The Chemistry Kracken”. Are all electrons really created equal or does our body account for the types of foods that certain electrons come from? I honestly think I know this answer, but I wanted to ask the smartest man in paleo; but I can not get away from why would a ketogenic diet high in MCT do something radically different to brain metabolism and CBF that carbs and protein do not. I think its a question that needs an answer. Remain curious folks!!!

Answer by The Quilt for Does the effect of melatonin reveal a snapshot of your own production?

2013-03-31T14:39:09Z

Here is an excerpt on melatonin:
WHAT HAPPENS WHEN THIS IS ALTERED IN MODERN HUMANS?

Well, when a man or woman ages is like an instructive test case for us as clinicians. Peri and PM women have mental fog and fatigue and lowered energy and cant sleep well at all. Men with andropause have the same issues. This sounds eerily similar to what a diabetic faces every day of their life as well. Very few people have put these two syndromes together clinically, but PM women and men with andropause, are a microcosm of what a T2D faces daily. Let’s examine this link further.

All diabetics are leptin resistant and that implies their hormones are disordered by the very nature of the biologic process. Diabetics get this disorder from altered light cycles and excessive carbohydrates out of season. PM get this too on a smaller scale when their ovaries fail. These processes are commonly thought to happen in diabetics because of diet alone, but most of my readers now know about the temperature and light effects are far bigger issues than modern healthcare realizes. This is why I mentioned the medication Cycloset earlier. Cycloset was approved for diabetics in 2009, but few physicians even know about it, or how it works in our brain to reset the circadian clock once it has been fast forwarded by mismatches. It works on the brain to fix the circadian mismatch that light and carbs cause when they are used out of their normal cycles. We look for altered AM and PM cortisol levels on an adrenal stress index test for a clue this is happening. It eventually results in the brain by lowering the dopamine pathways centrally.

Cycloset actually raises your AM cortisol spike that we normally see in a normal humans. I covered this extensively in my August webinar for members on my site. It resets the cortisol/DHEA/melatonin axis of the hypothalamus. When the circadian cycle is off we usually see low melatonin levels. Low melatonin levels are consistent found in epithelial tumors. In modern humans all epithelial cancers rates are exploding. Maybe now you might realize why.

Melatonin is the third most important anti-oxidant in the human brain. When melatonin is lowered chronically for any reason, we see a sharp rise in epithelial cancers. Epithelial cancers have risen dramatically since 1924. When Cycloset was approved for use by the FDA in 2009, it validated all my empiric clinical observations of what really causes diabetes and cancer. I believe the environmental mismatches that have gone on for decades are the real etiology for the modern epidemics we are seeing explode in medicine. It is due to a modern human never facing a true winter, and never giving the brain the appropriate sunlight and sundown stimulus it needs to function optimally.

Prior to 1924, we never had to worry about artificial light much. If you look at the incidence and prevalence of T2D and cancer since 1924, be prepared to be astounded out what I just laid out here. Diabetes and cancer may not be a disease after all. I said this earlier in the year in the Cold Thermogenesis series. They maybe an epigenetic phenomena of modern life!

This was from here. http://www.jackkruse.com/brain-gut-11-is-technology-your-achilles-heel/

Answer by The Quilt for Magnesium issues

2013-03-31T14:32:34Z

Mg wont work if you are dehydrated. You can check this via your BUN/ Creat ration on a metabolic profile. The paleo diet acts to dehydrate you so taking more Mg does nothing until you add non fluoridated water to lower your BUN creat ratio below 10:1. 7:1 is optimal. The reason for this is magnesium is hydrophilic and it can not work on the 60 enzymes it does when there is no coherent intracellular water present. I covered this in this blog: http://www.jackkruse.com/emf-rx-the-top-ten-emf-faqs/ but I really covered it in some detail in the EMF Rx webinar of March 2013. http://www.jackkruse.com/march-webinar-the-emf-rx/

Answer by The Quilt for Hack my constipated self...

2013-03-17T12:44:03Z

http://www.jackkruse.com/quantum-biology-2-quantum-pcos/

http://www.jackkruse.com/emf-rx-the-top-ten-emf-faqs/

Answer by The Quilt for circadium rythym, sleep, are some of us night-owls by nature?

2013-03-15T10:48:08Z

https://www.facebook.com/groups/426721967404475/

Answer by The Quilt for Help, doctor wants to take gallbladder out!

2013-03-15T02:36:27Z

http://www.jackkruse.com/cpc-3-do-you-need-a-gallbladder/

Answer by The Quilt for Magnesium and Exhaustion Link?

2013-03-14T22:34:14Z

The reason is the Mg needs to be dissolved in water inside the cell......to work properly. My bet is your BUN/creat ratio is high and your LDL is high....and iodine and DHEA low.

Answer by The Quilt for Is breastfeeding a dying art?

2013-03-14T22:32:04Z

http://intoxicatedonlife.com/breastfeeding-tips/

Answer by The Quilt for can I overdose on Omega 3?

2013-03-13T13:35:33Z

Be careful with excessive fish oil.......it can cause many medical problems.

Answer by The Quilt for Omega 6 concerns and Ray Peat

2013-03-06T00:46:14Z

Many times we hear in the paleo world talk about the wonderful things omega three fats do for us. We also hear about the many bad things that omega six oils can do to us. We rarely hear about why O6 fats are good or in fact necessary. Well, they are folks. In fact, we need them in EXCESS as compared to O3 fats! Most invoke the standard American diet (SAD) argument because a processed food diet has 25-40 to one ratio of omega 6 to three ratios compared to an ancestral diet as outlined by Cordain et al. This information is true to some degree but the story has many nuances that one needs to understand for optimal health in my view. Lets take a look at some of the data we should be mindful of.

What exactly are the paths that EFA travel in humans? Is the pathway of all omega six fats inflammatory? Is the current concept of a dietary balance omega-6/3 ratios based on a true biologic reality? We also hear a lot of background posting about the “inflammatory pathway” from linoleic acid (LA) to arachadonic acid (AA) as the main argument against dietary sources of O6 fats. This is the AA pathway that leads to the formation of prostaglandins. Interestingly, the real pathway that O6 fats travel is not to just foster inflammation, but to also limit it. Many researchers and bloggers assume that the pathway from AA to PGE2 is a constant finding if we eat dietary excesses of O6 fats. This is not true at all. The interesting finding is that the body only produces PGE2 when it is actually needed by the body. It does not happen with the excess consumption of omega 6 by itself. In fact, most EFA are produced in the human body on an ad needed basis. So, AA is not dangerous in an of itself. The adverse effect idea arose because of the role of AA as a precursor of thromboxane and other eicosanoids participating in activating thrombus formation and the inflammatory process. But this is not the only thing AA does in the human body! If it was I would never be able to operate on anyone!

AA is a major component of the endothelial [inner arterial lining] phosphoglycerides, particularly on the inner cell membrane layer. AA and adrenic acid are consistent companions in other cell membranes. It is the precursor for prostacyclin: a vasodilator and inhibitor of platelet adhesion; it is the most potent platelet inhibitor we know of in nature. This stops the clotting process when it is no longer needed. It is also vital to smooth vascular and laminar flow and allows us to overcome wounds we sustain in injury or create in surgery by helping seal the wounds. If there is damage to the endothelium, such as in bruising, infection or cutting, then the phospholipases release AA. In the free form, and in conjunction with activated platelets, AA is peroxidized to provide eicosanoids for the response to injury. This is how the body is supposed to work. I rely on O6 fats every day in surgery to get people to clot and off the operating table.

Moreover, in vivo, we never find prostaglandins from omega 3′s or from omega 6′s acting alone. They act in concert as a violin and violinist would. One without the other is simply useless. PGE1 is made from omega 6 fats and is a fast acting pain inhibiting cytokine that also modulates the immune response to an injury. PGE3 is made form omega 3 fats and has similar function but the PGE1 response is more brisk and powerful to help in wound healing. They always act in unison and are symbiotic. This is why when someone takes too many omega 3′s in supplement form we often can see skin bleeding and discoloration and frank internal bleeding. It is also why when our ratio is 40 to 1 due to processed foods we see the opposite end of the spectrum. But we must realize it is in fact a spectrum of balance that we need to strive for.

As explained above, the western diet is estimated to have undergone a huge shift in the omega 6 to 3 content since 1900. Many place the spike in neolithic disease at this concomitant spike over the last 110 years. Our bodies target ratio’s of EFA should still be capable of oxygen-transference ratio of a maximum of 6 to 1 omega-6 to omega-3 for good functioning. So if you understand biology, humans need more O6 fats than O3 fats normally in their diet to function optimally. So it should now be clear that AA is not the dark side! If we could get it to two to three to one ratio it likely would be ideal, but with today food sources I think this is rather difficult to do without a lot of money and time.

A word of caution: I am one of the few who think there is a major benefit to 06′s in mammalian biochemistry. The real problem we have with 06 is the shear number and amount in balancing the 03 for ideal proper cell membrane signaling. This ratio is critically tied to the environment we are adapted too. Most in our community fail to realize this point because they really do not understand how mammalians use 06′s to their advantage.

The other interesting factor I have seen few speak of is the requirement that each organ of the body has for omega 6 and 3 fats. I decided to look into this issue more several years ago when I was researching my own health. I always believed that the brain had a large omega 3 component naturally and it turned out, I was dead wrong. The brain makes up 3% of our body weight (BW) but has a 100 to 1 ratio of 06 to 03 within it normally!!! Most of that is DHA and EPA protected by iodine and CSF for semi conduction. It works when the BBB is not permeable from the usual sources. It appears the 06 to Phosphotidyl Choline and Phosphotidyl Serine ratios are more critical for cell membrane signaling for protein confirmational bending after proteins are made in the brain. This single insight made me realize that mammals do something special with their 06′s for some reason, so I looked deeper and found that answer.

It appears in certain diseases of the brain the ratio gets dramatically altered and may actually be a good biomarker for us to use diagnosis and prognosis in neurodegenerative disorders. Skin makes up 4% of our BW and has 1000 to 1 ratio normally. Skeletal muscle makes up 50% of our BW and sets at a 6 to 1 ratio. Our internal organs, make up 9% of our BW have the lowest ratios at 4 to 1. Adipose tissue sits at 22 to 1 ratio and makes up 15-35% of our total BW depending upon how fat we are.

Summing it all up:

THE MOST IMPORTANT FACTOR IN THE O6/O3 ratio is CONTEXT!!!!! Many in the paleo sphere do not give that context.

Answer by The Quilt for Rapid Weight Loss...Neurotoxicity?

2013-03-04T13:15:47Z

Monte I answered this on the thread too. Sounds like extreme dehydration caused an acute pregnenolone steal.......and affected BDNF and NGF........Pretty common on a paleo diet change over especially if the diet is loaded with a ton of starchy carbs. Pops you out of PPP and keeps you in ATP-CP and TCA constantly. EMF 4 essentially done way to fast........

Answer by The Quilt for Switching energy sources quickly might cause sleep problems?

2013-03-02T02:15:02Z

Here is why.......you're a fast ATP recycler not an efficient one chronicly and not using PPP or DHEA. It destroys sleep.

http://www.jackkruse.com/emf-4-why-might-you-need-carbs-for-performance/

Answer by The Quilt for Mom's question to me... "So how does a 57 year old woman use paleo to help prevent osteoporosis?"

2013-02-26T01:38:50Z

http://www.jackkruse.com/emf-8-quantum-bone/

Answer by The Quilt for Anyone have bone density Z-score and/or T-score improve with Paleo? Anyone with osteoporosis improve with Paleo?

2013-02-26T01:37:58Z

http://www.jackkruse.com/emf-8-quantum-bone/

Answer by The Quilt for Meat and Poultry Leeching Calcium From The Bones ... Contributing to Osteoporosis?

2013-02-26T01:37:15Z

http://www.jackkruse.com/emf-8-quantum-bone/

Answer by The Quilt for I have Osteoporosis

2013-02-26T01:35:23Z

http://www.jackkruse.com/emf-8-quantum-bone/

Answer by The Quilt for emf radiation from electric razor?

2013-02-15T06:21:45Z

http://www.jackkruse.com/emf-5-what-are-the-biologic-effects-of-emf/

Answer by The Quilt for Ron Rosedale and Jack Kruse have two different approaches. Which one is better? Why? And under what circumstances?

2013-02-15T00:17:29Z

So you all pounded me into the ground when I made the case in Cold Thermogenesis 4 that I was correct about MTor and primates.......

Look what popped up today: www.nature.com/nature/journal/v489/n7415/full/nature11432.html

Become aware of what you do not know........it might just kill you.

Here is the original post: http://www.jackkruse.com/the-holy-trinity-ct-4/

Answer by The Quilt for How to eliminate lower back pain in the mornings?

2013-02-11T23:44:46Z

There is a lot of back pain info in this blog I wrote. I do a lot of this for my spine patients. Iodine, DHA, Cu, Zn, Mg, Fe are massively important for LBP

http://www.jackkruse.com/brain-gut-17-the-power-squat/

Comment by The Quilt

2013-05-17T01:45:43Z

ferritin is low because you have an issue with iron.....might be simple like anemia but based upon your otet post labs.....its not that simple.....my bet is your DHEA is the real issue........

Comment by The Quilt

2013-05-17T01:43:45Z

no......its not. Your free T 3 is low......real low. you got pregnenolone steal........time to upgrade your game with labs. 1.jackkruse.com/what-are-the-optimizing-labs 2.jackkruse.com/hormone-cascade-101

Comment by The Quilt

2013-05-16T03:52:36Z

Actually what I am saying is you have to know your context before you act or make changes......for most people the assumptions made by the paleo community are very cookbook and boilerplate when they should be customized. simplified carbs in any diet will not help you.....no matter your template because of what they do to cytochrome one.....regardless of what paleo leaders say. jackkruse.com/…

Comment by The Quilt

2013-05-02T02:56:04Z

Maybe you're not as advanced as you believe then. jackkruse.com/…

Comment by The Quilt

2013-04-14T22:35:41Z

kristensraw.com/blog/2013/03/17/…

Comment by The Quilt

2013-04-04T21:37:03Z

pathetic........

Comment by The Quilt

2013-04-03T11:43:16Z

You're very welcome

Comment by The Quilt

2013-04-01T01:50:52Z

Now you can see why when this pathway is activated many bad things can happen that are common to T1D, T2D, most cases of leptin resistance with elevations in HS CRP. These steps are stops on the way to either final pathway and we call them neolithic diseases. Yes.......you got an insight into Quantum Metabolic syndrome early. We are not making it complicated....it is. This response is the proof of just how complicated it is.....and you need to have a lot of science background to understand this complexity......believe it or not I leave a lot of it out on purpose.....but not in this response

Comment by The Quilt

2013-04-01T01:47:55Z

The follow through? AKT1 is involved in the PI3K/AKT/mTOR pathway and other signaling pathways. These all cause massive changes in cell cycle signaling and in cellular communication. mTOR is huge in longevity and in cancer progression via the dis-regulation of the p 53 gene.

Comment by The Quilt

2013-04-01T01:45:10Z

This is what causes brain shrinkage in all the neurodegenerative disorders that are linked to cytochrome 1 issues. PCOS is tied to this early one before the more chronic diseases come to the forefront. Akt2 is an important signaling molecule in the Insulin signaling pathway. It is required to induce glucose transport.

Comment by The Quilt

2013-04-01T01:43:03Z

In a mouse which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth. In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance/ T2D), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. It has been reported that mice lacking Akt3 have small brains.

Comment by The Quilt

2013-04-01T01:42:43Z

processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming

Comment by The Quilt

2013-04-01T01:42:29Z

Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to NAD and NADP in vivo and this information is very valuable when you have liver leptin resistance, metabolic syndrome, or epilepsy. When cytochrome 1 has mis-folded electron transport proteins (quinolone issue of CoEnQ10) you need to bypass it 100% of the time by eating fats predominately because if you don't, your mitochondria begin to make massive ROS that overwhelms the cell lowers vitamin D and all hormones, causes pregnenolone steal syndrome, and eventually shortens its telomeres to cause cellular

Comment by The Quilt

2013-04-01T01:41:46Z

works in these diseases because it is a ketone mimic drug. Why? Niacin also known as vitamin B3, nicotinic acid and vitamin PP, is an organic compound with the formula C6H5NO2 and one of the 40 to 80 essential human nutrients. In fact, when niacin deficiency is present it is one of 5 vitamins that causes a pandemic disease condition called pellagra. But it can be used to bypass a "broken" cytochrome 1 when mis-folding (due to a chronic ATP deficiency think EMF 7). But why kathylu? Why am I tormenting you with this science,.......because you are biochemist........and you will see where QED take

Comment by The Quilt

2013-04-01T01:41:37Z

here is the thread:When you eat a ketogenic diet guess what else happens.......we bypass complex one at the inner mitochondrial membrane and enter FADH2. You heard about this in the Quantum electron post.........but what did not I tell you? Why does a ketogenic diet work in T1D, T2D, and to lose weight? When you lose water conduction at the inner mitochondrial membrane you lose the ability of proper nanoscopic protein folding of cytochrome 1. This throws off the nanoscopic precision required for quantum tunneling and this cause increased ROS and metabolic syndrome.......This is also why niacin