Default 150

Genetics Questions

Genetics

All Questions

B121fdbc1aaa6130f5bda3bf84e3ba2d
0
Votes
0
Answers
3
Views
439
by 952 · June 07, 2014 at 3:37 AM

What is the easiest way to figure out the minimal effective dose of supplementation and dietary change to adjust for the following genetics? It seems that I have minor defects, but nothing serious. All other things being equal, I would love to... (more)

best answer

Cf08ad26759fdd206a2c9f9385080a57
paleot 0 · June 06, 2014 at 9:19 PM

That looks like a great methylation panel to me. A66G is your only red mark, where that's a fairly mild mutation. A1298C is fairly mild as well, and you're hetero there. You could maybe eat some more seafood and veg (beets / spinach.) I would be... (more)

Cf08ad26759fdd206a2c9f9385080a57
1
Votes
1
Answers
1
Views
573
by 992 · July 20, 2013 at 4:19 PM

I'm looking for any suggestions for eating / supplementing with this in mind:

7a6529ea25b655132fe58d793f95547a
Colin_1 0 · July 20, 2013 at 4:19 PM

You have different mutations than me so I'm not much help, but here are some good... (more)

Bcb2f5436d11467e89123680c046b858
1
Votes
1
Answers
4
Views
606
by 1314 · July 11, 2013 at 6:10 PM

I've been researching celiac disease a ton over the past few days since getting my 23andme results back. It's a very confusing tangle of genes, but it looks like I'm heterozygous for the "celiac genes", both HLA-DQ2 (2.5, but not 2.2) and HLA-DQ8.... (more)

Bcb2f5436d11467e89123680c046b858
Annika 0 · July 11, 2013 at 6:10 PM

Okay, after more research, I think I've managed to answer my own question. The information was not easy to find - there is very little on prevention of celiac disease, except with reference to infants. Most consumer-level references I looked at... (more)

47e6e0027419735a808a96084425ea1e
0
Votes
0
Answers
1
Views
502
by 0 · November 01, 2013 at 12:57 AM

Hi, I have recently taken Genova's DetoxiGenomic Profile. Apparently I am absent of the GSTM! Glutathione gene. If glutathione supplementation is useless, what would you recommend I do? Regards, Neil.

1d7c40e665b1f1cc2c4fba666e1b6068
glutathione_pro 0 · November 01, 2013 at 12:13 AM

Glutathione supplementation is no longer useless. While most glutathione supplements are ineffective because they are broken down in the gut before they can be absorbed, you can overcome this. Either supplementing with the precursors of... (more)

3fc95bca9e723edfbbb72b172798ab49
0
Votes
0
Answers
2
Views
850
by 1321 · March 16, 2013 at 11:35 PM

We are our genes, but our genes are not our fate. As a paleo community we tend to concern ourselves greatly with our natural heritage, our predispositions and our gene expressions. We are very interested in bringing out the best of what we are and... (more)

Bfd70bb38267fcc2d762063d691fa226
flowers 0 · March 16, 2013 at 11:35 PM

My best guess is that you can make them more prominent by working those particular muscles and having a relatively low body fat. Unless you have a birth defect or other muscular disorder that would cause these particular muscles to be absent, I... (more)

B121fdbc1aaa6130f5bda3bf84e3ba2d
0
Votes
0
Answers
0
Views
330
by 952 · March 02, 2013 at 8:11 AM

Anyone tried it? What is better NAC or gluthaionine? I found this interesting paper which supports supplementation with NAC and couple of other gluthaionine precursors: http://www.ncbi.nlm.nih.gov/pubmed/17914184 Any APOE 4/4 who actually tried... (more)

B121fdbc1aaa6130f5bda3bf84e3ba2d
4
Votes
4
Answers
3
Views
3.4K
by 952 · December 04, 2013 at 5:49 PM

Dear all! What do you think about creating the ultimate hacking thread for Apo-ε4/ε4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)

B121fdbc1aaa6130f5bda3bf84e3ba2d
John_11 0 · March 09, 2013 at 11:08 AM

I just had a conversation with a Prof. Dr. Andro from Suppversity.blogspot.com and he shared several ideas fro APOe 4/4 that I would really love to hear others' opinions on. Here they are: try to keep GSH up (NAC, Alcar, SAM-e), better regular... (more)

B121fdbc1aaa6130f5bda3bf84e3ba2d
1
Votes
1
Answers
2
Views
808
by 952 · February 27, 2013 at 8:57 AM

For those who got APOE 4/4 result on genetic testing (http://snpedia.com/index.php/APOE). What have you learned during your experimentation with diet, supplementation and with overall lifestyle changes?

B121fdbc1aaa6130f5bda3bf84e3ba2d
John_11 0 · February 27, 2013 at 8:51 AM

I have created new, more detailed post, please, join in and upvote! http://paleohacks.com/questions/182079/ultimate-apo-4-4-paleo-hacking-thread#axzz2M0WN91dm (more)

7dab2d8c97e44d8d0c298e5c9d5d75bc
1
Votes
1
Answers
2
Views
1.2K
by 632 · January 19, 2013 at 9:34 PM

Hey all, I need to do a genetics paper, and it's pretty free reign. This is the assignment: The Final Project A term paper is required. The term paper is due when you turn in your final assignment. Please submit the paper as a Microsoft Word... (more)

E35e3d76547b18096a59c90029e7e107
David_Moss 0 · January 19, 2013 at 9:34 PM

How substantial the alteration of our genetics has been since the neolithic? I don't know whether that meets the remit or is too macro an issue. Consider this summary of the debate on wikipedia: According to Alexander Ströhle, Maike ... (more)

C4a0c9f9a748f1d3354055bc6d020c7e
7
Votes
7
Answers
8
Views
1.3K
by 298 · August 08, 2013 at 9:29 AM

I thought this might be of interest to some of the folks on here. It is a free online course offered by Duke University called "Introduction to Genetics and Evolution". https://www.coursera.org/course/geneticsevolution (more)

79efc04970cc23409a9d8e4dab01fd0f
PaleoSarah 0 · July 03, 2013 at 8:16 PM

Wow! Thanks! Now I will take part in it.

Bee4e0fda817da9857443bd40f552a75
1
Votes
1
Answers
5
Views
1.1K
by 239 · December 07, 2012 at 1:53 PM

I just wonder why it happens?

Ee6932fe54ad68039a8d5f7a8caa0468
jake_16 0 · December 06, 2012 at 11:20 PM

are you kidding? i spend hard time and effort in the gym trying to get a bigger ass. no joke!

4517f03b8a94fa57ed57ab60ab694b7d
4
Votes
4
Answers
6
Views
1K
by 227 · February 22, 2014 at 4:08 PM

Did you learn something that lead to a significant change in your daily routine? Do you think your health will be even better now that you have this new information? Do you trust the results? Do you think the science is too young to be... (more)

96440612cf0fcf366bf5ad8f776fca84
raydawg 0 · February 22, 2014 at 4:08 PM

Had to get mine through http://ancestry.com due to the stupidity of NY state legislation as well as the FDA's chest pounding. I fed the results to http://promethease.com and http://geneticgenie.org Looks like I have two MTHFR mutations as... (more)

4517f03b8a94fa57ed57ab60ab694b7d
1
Votes
1
Answers
2
Views
471
by 227 · December 12, 2012 at 4:22 AM

Is this done through one's doctor, or is there a more accurate genetic testing method that one's doctor might not be aware of? Is there a lab out there that studies this particular genetic condition that also offers testing to the public? I am... (more)

79fc447191de75e7c178951594a43f13
JRM 0 · November 28, 2012 at 3:48 AM

23andme.com is probably cheaper than going to your doctor. I tested there and found out I don't carry the mutations.

3bc294cb7745a5e99612ff886ca00101
2
Votes
2
Answers
3
Views
744
by 1174 · October 24, 2012 at 6:39 PM

Since a good part of the paleo rationale is based on the idea that we are not genetically adapted to eat a certain way, it seems very relevant and quite interesting to look at this example of how quickly such a genetic mutation/adaptation can... (more)

7bf306ada57db47547e9da39a415edf6
August 0 · October 24, 2012 at 6:15 PM

There is still the question as to whether or not milk proteins from other animals are actually good for us. Casein was the only animal protein Campbell had any scientific reason to correlate with cancer in his crappy China study. Now, in times... (more)

C2ecbc6f2948c232d60a639c50b7f4f9
1
Votes
1
Answers
2
Views
426
by 487 · November 13, 2012 at 5:22 PM

Since there is talk about gaining weight all over paleo hacks, i was wondering when played defensive end in high school when i weighed 240 (im 190 now) i was benching 325 for reps, powercleaning 260 for reps, and deadlifting 450-480 pounds, this... (more)

85026a0abe715229761956fbbee1cba0
dzone 0 · October 24, 2012 at 7:40 AM

For that type of very respectable performance most definitely genetics. There aren't too many 18 year olds benching 325 for reps without the gear, unless they've been dealt a good hand of genes. As always, be grateful to your parents :) (more)

7cf9f5b08a41ecf2a2d2bc0b31ea6fa0
6
Votes
6
Answers
6
Views
715
by 4176 · August 08, 2012 at 1:21 PM

I don't see my dad that much but when I did the other day I noticed that his skin is not great, my mum's seems ok but i think she wears foundation. My own skin is not great also, quite a few bumps and spots which don't really bother me too much... (more)

best answer

510bdda8988ed0d4b0ec0b738b4edb73
miked_2 0 · August 07, 2012 at 9:29 PM

I'm firmly in the lifestyle camp. What I mean by that is that while your genes determine your potential, your lifestyle affects the expression of those genes (epigenetics). Your DNA is just a list of instructions for things, however whether or... (more)

85026a0abe715229761956fbbee1cba0
0
Votes
0
Answers
0
Views
187
by 77348 · August 06, 2012 at 1:39 AM

You know those guys you see who are naturally muscular and barely lifts weights? How do you explain that? I kind of envy them. I have sucky genetics and have to work my ass off for every inch of muscle i gain. Thoughts?

85026a0abe715229761956fbbee1cba0
-4
Votes
-4
Answers
3
Views
429
by 77348 · August 06, 2012 at 1:22 AM

Is it paleo to masturbate too much? Should i save my for loads for procreation purposes only? Will i ever get to pass my genes on?

5af4bc9d2c390b0bcad9524f149c1b4f
red_leaf 0 · August 06, 2012 at 1:22 AM

I know we like food and all but... don't feed the troll.

D01e44fabc04e69a92e65e3179d81e06
6
Votes
6
Answers
7
Views
1.9K
by 72 · July 30, 2012 at 7:21 AM

My son (1.5yo) was just diagnosed with a very, very rare genetic disorder (Primary Hyperoxaluria Type III). The specialist who actually described this disease hypothesises that the genetic mutation causes the pathway for the proper breakdown of... (more)

9a5e2da94ad63ea3186dfa494e16a8d1
UncleLongHair 0 · July 30, 2012 at 4:16 AM

A friend of mine's kid had a lot of digestive issues for his first 5 years, he was at times diagnosed with various food allergies (dairy, protein, wheat, sugar, etc), later with "leaky gut", and some other things mixed in. She went through at... (more)

D13278772f6612432bf53413fad4e7af
6
Votes
6
Answers
7
Views
1.2K
by 731 · August 03, 2012 at 3:13 PM

As I understand the core argument for paleo, modern man retains what is essentially a 100,000-year old gene map, and many of our current health and psychological issues result from nutritional and behavioral departures from what Grok's genome was... (more)

best answer

81fca18329e68e227cdfef3857bfef96
Mark_26 0 · July 18, 2012 at 9:33 PM

I would agree with the second paragraph that human beings are no longer evolving due to natural selection. The moment humans began adapting the environment to suit their needs they no longer adapted themselves to the environment. Essentially,... (more)

7fb4e9fb1162999cdd5099fee49dd0a7
0
Votes
0
Answers
1
Views
622
by 401 · July 14, 2012 at 11:40 PM

Just to clarify, the title was just a way of posing this as a question. Obviously the NY times just report the news, so I don't hold them responsible for reporting this crap, but it was prescient enough and is trending on a prolific tech news... (more)

85026a0abe715229761956fbbee1cba0
dzone 0 · July 14, 2012 at 11:40 PM

This part is particularly troubling: "Did people unexpectedly gain or lose weight when they had the same amount of calories but in a diet of a different composition?" No. There was zero difference between high-fat and low-fat diets. Despite... (more)

85026a0abe715229761956fbbee1cba0
6
Votes
6
Answers
9
Views
1.5K
by 77348 · November 16, 2012 at 7:13 AM

Paleo is a wonderful notion - to emphasise the dietary practices that our bodies, due to evolution, are best suited to. This principle seems to work particularly well when compared with diet plans that are extremely unsuited to the expectations... (more)

1da74185531d6d4c7182fb9ee417f97f
Ashley_Roze_ 0 · November 01, 2012 at 4:53 PM

Is it really genetics that are playing in to us reacting to dfferent diets or is it just our screwed up/ varying gut flora from dead soil, overuse of antibiotics and antiseptics, and all the pesticides/herbicides, and fungicides in our food... (more)

9d43f6873107e17ca4d1a5055aa7a2ad
4
Votes
4
Answers
7
Views
1K
by 55320 · June 23, 2012 at 2:48 PM

I was talking with some relatives who have stomach problems and one thing I noticed is that a lot of them are on NSAIDs- ibuprofen and aspirin, for example. Over the years I have been on and off the paleo diet, but never gotten back to the point I... (more)

Bbb65dfde2b925e334048eb6438b3950
coffeeandcream 0 · June 23, 2012 at 9:10 AM

If memory serves me right my pharmacology professor told us in class that NSAIDs are nasty, extremely overused and would most likely not pass regulation if they were to be registered as a new drug today. They destroy the lining of the stomach.... (more)

F31d10b54b31428e189d9b771bf7b1d1
0
Votes
0
Answers
4
Views
459
by 1448 · May 29, 2012 at 4:38 AM

When we observe the diets of primitive tribes currently still in or close to the stone age, we see that they vary quite a bit. For example, the Kitava Island folks eat a lot of carbs (by our "paleo" standards), and the Inuit-like folks in north... (more)

F5a0ddffcf9ef5beca864050f090a790
VB 0 · May 28, 2012 at 7:30 PM

I disagree. Paleo IS THE SAME THING. Why? Simple. If you look at all the indigenous people around the world and at our nutritional history, it is very very easy to figure out what those people eat /ate. No, Paleo is not a re-enactment. It is... (more)

E9c1630487f5a2b54898131e5c19e32f
0
Votes
0
Answers
2
Views
661
by 0 · December 02, 2012 at 7:11 PM

I'm being hopeful... This is a long shot and I'm pretty sure nobody will answer...but is there anyone with NF out there who is on paleo? Do you think that it will help with any of the symptoms? Thanks in advance.

100f7a85a1708fe39b9e57e306f2ba00
Marya 0 · December 02, 2012 at 7:11 PM

how has it been working for you? I just started paleo for my own neuro condition but wonder if it could hlp my son who has NF1. He is pretty asymptomatic so far.