Genetics

Genetics

Genetics Questions

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by 9647 · about 8 hours ago

Just the question as it stands, really. Is anyone out there familiar enough with this academic community to know if the diet has taken on? And when I say anthropologists I mean the scientific kind (physical anthropology, etc.), not the ones who... (more)

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Patrik 0 · October 09, 2010 at 10:59 PM

This is gonna be a fun one. Gonna approach in a pretty similar manner to Matthew. Full disclosure: I hold a BA in Physical Anthropology from university that houses some of the "rock-stars" of evolutionary psychology (a branch of physical... (more)

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by 1336 · about 8 hours ago

I've been researching celiac disease a ton over the past few days since getting my 23andme results back. It's a very confusing tangle of genes, but it looks like I'm heterozygous for the "celiac genes", both HLA-DQ2 (2.5, but not 2.2) and HLA-DQ8.... (more)

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Sara_S_ 0 · July 06, 2013 at 8:08 PM

Do you have any relatives with celiac disease? I personally think it's a good idea to get tested before going gluten free, as many people are asymptomatic. I think most doctors aren't keen to test you unless you either have symptoms of celiac... (more)

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by 0 · about 9 hours ago

Hi, I have recently taken Genova's DetoxiGenomic Profile. Apparently I am absent of the GSTM! Glutathione gene. If glutathione supplementation is useless, what would you recommend I do? Regards, Neil.

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glutathione_pro 0 · November 01, 2013 at 12:13 AM

Glutathione supplementation is no longer useless. While most glutathione supplements are ineffective because they are broken down in the gut before they can be absorbed, you can overcome this. Either supplementing with the precursors of... (more)

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by 1336 · about 9 hours ago

We are our genes, but our genes are not our fate. As a paleo community we tend to concern ourselves greatly with our natural heritage, our predispositions and our gene expressions. We are very interested in bringing out the best of what we are and... (more)

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animalcule 0 · March 15, 2013 at 6:05 AM

Most things about the way any modern human looks are a mixture of genetics, epigenetics, and environment/nurture/'the kitchen'. This is certainly true of that particular anatomical feature. I'm not muscular (thin), don't have crazy low body fat,... (more)

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by 952 · about 9 hours ago

Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)

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Cave_Chick 0 · March 12, 2013 at 10:49 PM

According to 23andme I'm a 4/4 (and 3.1% Neanderthal!) and I notice MUCH better energy, cognition and fat loss when I eat large amounts of coconut oil daily. High quality coconut oil can be expensive, so at times I've stopped buying it to save... (more)

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by 240 · about 9 hours ago

I just wonder why it happens?

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Kashkillz 0 · December 06, 2012 at 10:06 PM

Kettlebell... squats... lunges... plyometrics... You are not a victim!!!

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by 72 · about 9 hours ago

My son (1.5yo) was just diagnosed with a very, very rare genetic disorder (Primary Hyperoxaluria Type III). The specialist who actually described this disease hypothesises that the genetic mutation causes the pathway for the proper breakdown of... (more)

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Matt_11 0 · July 28, 2012 at 12:24 PM

Not sure I understand how a vegan diet minimizes oxalates... which is the problem with hyperoxaluria. Oxalates are absent in animal products, and present in many plant foods. I'm guessing it stresses the kidneys so they're just trying to minimize... (more)

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by 5002 · about 9 hours ago

I'll start with my question: Do you agree with Melissa McEwen's critique of Jack Kruse's (mis)use of evolutionary biology? I should note that I am a fan of both McEwen and Kruse. McEwen's blog post is... (more)

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Bread_Eating_Beelzebub 0 · April 02, 2012 at 3:34 AM

You have no idea how hard that post was to write. I mean, it's so hard to read Dr. Kruse's writing and find consistant threads in it. He has references on the bottom of some post, but mostly they do not correspond to things in his posts that I... (more)

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by 203 · about 9 hours ago

Hi! Because of constipation, which is now better, my G.I specialist got me to take a blood test to see if I have celiac or not. The results were that I'm a carrier for Celiac disease but it came back negative. My aunt didnt develop properly... (more)

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Mscott 0 · March 24, 2012 at 3:07 AM

If you haven't been eating gluten leading up to the blood test the ability of the test to identify celiac disease drops considerably. I know someone who stopped eating gluten, felt much much better, then went to the doctor a few weeks later to be... (more)

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by 35 · about 9 hours ago

Hi! Who here legitimately forgets to eat? Or has less interest in food than people in general? I've had a brief history of overeating, but that was due to addictive foods on the S.A.D that I leeched onto after being through a long period of... (more)

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Mash 0 · January 26, 2012 at 9:57 AM

I generally have to force myself to take time to eat, and very often on weekends when I am writing code, I eat breakfast and then not again until around 23:00 that evening. It's not a lack of love for food, it's just being overly focused, coffee,... (more)

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by 1186 · about 9 hours ago

Pyroluria-- Is it real? Is it permanent? Those that pay attention to it regard it as genetic, requiring permanent B6 supplementation. Nora Gedgaudas in "Primal Mind Primal Body" has a whole appendix on it and seems to share this view. Any... (more)

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Harry_3 0 · May 16, 2012 at 10:56 AM

Oh its real alright. I have Pyroluria, it took me 8 years to work out what caused all my symptoms, these symptoms included: Brain fog Poor concentration and memory Depression Anxiety Chronic fatigue (really adrenal fatigue) Digestive... (more)

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by 5002 · about 9 hours ago

I've always wondered if the different levels in carb tolerance that we often see has anything to do with genetic differences that related to ethnicity. I, for example, am half Italian (mother born there) and half Jewish-Russian (perhaps Belarus;... (more)

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Andy 0 · August 03, 2011 at 1:21 AM

Scotch/Irish and Seminole/Cherokee... very sensitive to carbs. I get fat easily if I eat too many, my blood sugar gets too high. Even when it comes to alcohol, I simply cannot tolerate it. 2 drinks and I'm done. But on the reservation, the... (more)

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by 12174 · about 9 hours ago

Non-Africans Are Part Neanderthal, Genetic Research Shows http://www.sciencedaily.com/releases/2011/07/110718085329.htm In light of these findings, is there anything that we can extrapolate about the nutritional needs (such as macronutrient... (more)

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Matt_1 0 · July 18, 2011 at 11:05 PM

Some non-African populations, sometimes mentioned here, with quite varying traditional diets include: Okinawans Chinese Kitavans Inuit Plains Indians Italians French Australian aborigines If all these populations are equally decended from... (more)

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by 56606 · about 9 hours ago

Chris and I were having a conversation about how some people do really awesome on pretty low carb and some people feel sick. I started getting curious about whether this might have something to do with "neanderthal ancestry." If you have DNA data... (more)

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Rose 0 · July 18, 2011 at 8:08 PM

What a great little gadget! I just ran mine and got a score of 20. I've been thriving on a "zero-carb" diet for the last two years, and have found that vegetables -- with the exception of some nuts (walnuts, macadamias) and dark leafy greens (e.g.... (more)

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by 135 · about 9 hours ago

Have there been any scientific studies that can conclusively indicate one race/ culture of a people is more predisposed to benefit more from eating paleo over another? My mother asked me why I eat paleo, which led to this question. We got a bit... (more)

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paleohacks 0 · June 26, 2011 at 2:57 PM

I recall someone else posting something about this before, eg. race-tailored paleo diet. I entirely agree and would like to encounter some studies related to phenotype, ethnicity, physiology and their interrelations as it relates to diet. The... (more)

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by 970 · about 9 hours ago

I had always assumed that the introduction of the SAD in our previous generation had detrimental epigenetic effects in our current one. This article seems to clinch it. Thoughts? http://web5.cns.utexas.edu/news/2010/12/you-are-what-your-father-ate/ (more)

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wjones3044 0 · December 24, 2010 at 3:12 PM

Interesting if true. Frankly I'm skeptical without knowing, among other things, the methodology of the mouse study and some sort of mechanism for transfer of "epigenetic" changes to offspring. We have one controlled study and two epidemiological... (more)

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by 24523 · about 9 hours ago

Someone mentioned this in Patrick's earlier thread, but let me make it abundantly clear-- 23andme.com is having a sale right now. They have a sale about once every couple years. Their ancestory/health DNA sequencing service is down from $499... (more)

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Carl_Stawicki 0 · December 14, 2010 at 1:51 PM

I would, but I would want to get it sequenced by a number of companies to compare results.

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by 20411 · about 9 hours ago

Was wondering what the survival advantage could have been and came across this paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917125/?tool=pubmed (full free text) From the abstract: "All humans are double knockouts. Humans lack the... (more)

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Levi 0 · October 28, 2010 at 9:09 PM

Good question. I've heard that it was a genetic mutation that we eventually were able to adapt to with diet. The other option is that because of our self-selected diet the ability to synthesize C was not preserved because it wasn't as needed. Gary... (more)

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by 56606 · about 9 hours ago

Evolution didn't just stop with the invention of agriculture. Genetics have changed and there have been some genetic changes in response to agrarian foods. These genetic changes generally only affect a certain percentage of the population, often... (more)

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Paul_1 0 · September 27, 2010 at 7:59 PM

I've been looking back through a lot of Stephan's older posts, and there's some really great stuff. Not that we didn't know that already. But I came across a nice post, short and sweet, "Grains and Human Evolution", which makes two important... (more)

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by 106 · about 9 hours ago

I know there are a lot of diseases that can be cured or greatly aided by going paleo, and i am all for trying to get people to believe that their ancestors didn't eat genetically modified 80+% starch corn and HCFS, but i think that our genetics... (more)

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Pieter_D 0 · September 09, 2010 at 12:56 PM

With the rise of agriculture, natural selection didn't stop! The selective pressure just changed. A lot. And very fast. But I don't know how this could contribute to the spread of some truly genetic diseases. So your question is a good... (more)

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by 65 · about 9 hours ago

Loren Cordain argues (without a citation) that the human genome has chagned only .02 percent in 40,0000 years. But other sources say that because of population growth, human genetics has changed much more rapidly in the last 5,000 years than the... (more)

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Domer88 0 · July 12, 2010 at 1:52 PM

The ability to do rapid analysis of the genome has radically changed our understanding of human genetics over the past 10 years, and the consensus is evolving (no pun intended). It is becoming clear that evolution continues unabated, even though... (more)

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by 952 · October 21, 2014 at 4:45 AM

Did you anyone took specific actions based on microbiome sequencing?

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by 952 · October 21, 2014 at 4:17 AM

Anyone tried it? What is better NAC or gluthaionine? I found this interesting paper which supports supplementation with NAC and couple of other gluthaionine precursors: http://www.ncbi.nlm.nih.gov/pubmed/17914184 Any APOE 4/4 who actually tried... (more)

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by 631 · October 21, 2014 at 4:12 AM

Hey all, I need to do a genetics paper, and it's pretty free reign. This is the assignment: The Final Project A term paper is required. The term paper is due when you turn in your final assignment. Please submit the paper as a Microsoft Word... (more)

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David_Moss 0 · January 19, 2013 at 9:34 PM

How substantial the alteration of our genetics has been since the neolithic? I don't know whether that meets the remit or is too macro an issue. Consider this summary of the debate on wikipedia: According to Alexander Str??hle, Maike ... (more)

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by 213 · October 21, 2014 at 4:09 AM

Did you learn something that lead to a significant change in your daily routine? Do you think your health will be even better now that you have this new information? Do you trust the results? Do you think the science is too young to be... (more)

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balor123 0 · November 30, 2012 at 9:50 PM

I used 23andme and Promethease as well. I was having some difficult to diagnose health problems and I thought that the genetic tests might help me narrow down other tests to pursue. People usually focus on the disease risk factors but it's worth... (more)

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