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Genetics Questions

Genetics

Paleo Questions

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by 952 · about 10 hours ago

What is the easiest way to figure out the minimal effective dose of supplementation and dietary change to adjust for the following genetics? It seems that I have minor defects, but nothing serious. All other things being equal, I would love to... (more)

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paleot 0 · June 06, 2014 at 9:19 PM

That looks like a great methylation panel to me. A66G is your only red mark, where that's a fairly mild mutation. A1298C is fairly mild as well, and you're hetero there. You could maybe eat some more seafood and veg (beets / spinach.) I would be... (more)

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by 952 · about 10 hours ago

Did you anyone took specific actions based on microbiome sequencing?

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by 1005 · about 10 hours ago

I'm looking for any suggestions for eating / supplementing with this in mind:

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Colin_1 0 · July 20, 2013 at 4:19 PM

You have different mutations than me so I'm not much help, but here are some good... (more)

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by 1336 · September 30, 2014 at 4:04 AM

I've been researching celiac disease a ton over the past few days since getting my 23andme results back. It's a very confusing tangle of genes, but it looks like I'm heterozygous for the "celiac genes", both HLA-DQ2 (2.5, but not 2.2) and HLA-DQ8.... (more)

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Sara_S_ 0 · July 06, 2013 at 8:08 PM

Do you have any relatives with celiac disease? I personally think it's a good idea to get tested before going gluten free, as many people are asymptomatic. I think most doctors aren't keen to test you unless you either have symptoms of celiac... (more)

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by 0 · about 10 hours ago

Hi, I have recently taken Genova's DetoxiGenomic Profile. Apparently I am absent of the GSTM! Glutathione gene. If glutathione supplementation is useless, what would you recommend I do? Regards, Neil.

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glutathione_pro 0 · November 01, 2013 at 12:13 AM

Glutathione supplementation is no longer useless. While most glutathione supplements are ineffective because they are broken down in the gut before they can be absorbed, you can overcome this. Either supplementing with the precursors of... (more)

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by 1336 · about 10 hours ago

We are our genes, but our genes are not our fate. As a paleo community we tend to concern ourselves greatly with our natural heritage, our predispositions and our gene expressions. We are very interested in bringing out the best of what we are and... (more)

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animalcule 0 · March 15, 2013 at 6:05 AM

Most things about the way any modern human looks are a mixture of genetics, epigenetics, and environment/nurture/'the kitchen'. This is certainly true of that particular anatomical feature. I'm not muscular (thin), don't have crazy low body fat,... (more)

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by 952 · September 28, 2014 at 3:55 AM

Anyone tried it? What is better NAC or gluthaionine? I found this interesting paper which supports supplementation with NAC and couple of other gluthaionine precursors: http://www.ncbi.nlm.nih.gov/pubmed/17914184 Any APOE 4/4 who actually tried... (more)

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by 952 · about 11 hours ago

Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)

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Cave_Chick 0 · March 12, 2013 at 10:49 PM

According to 23andme I'm a 4/4 (and 3.1% Neanderthal!) and I notice MUCH better energy, cognition and fat loss when I eat large amounts of coconut oil daily. High quality coconut oil can be expensive, so at times I've stopped buying it to save... (more)

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by 952 · September 28, 2014 at 3:54 AM

For those who got APOE 4/4 result on genetic testing (http://snpedia.com/index.php/APOE). What have you learned during your experimentation with diet, supplementation and with overall lifestyle changes?

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Alex 0 · February 25, 2013 at 2:22 PM

I'm E4/E4. During my 20s and 30s, my diet was heavily influenced by Indian vegetarianism, with a heavy emphasis on grains and beans. This resulted in a flabby, lethargic descent into middle age. In September 2003, I drastically cut back on all... (more)

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by 631 · about 11 hours ago

Hey all, I need to do a genetics paper, and it's pretty free reign. This is the assignment: The Final Project A term paper is required. The term paper is due when you turn in your final assignment. Please submit the paper as a Microsoft Word... (more)

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David_Moss 0 · January 19, 2013 at 9:34 PM

How substantial the alteration of our genetics has been since the neolithic? I don't know whether that meets the remit or is too macro an issue. Consider this summary of the debate on wikipedia: According to Alexander Str??hle, Maike ... (more)

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by 298 · about 11 hours ago

I thought this might be of interest to some of the folks on here. It is a free online course offered by Duke University called "Introduction to Genetics and Evolution". https://www.coursera.org/course/geneticsevolution (more)

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willis0037 0 · August 08, 2013 at 9:29 AM

Thanks for sharing, I will definitely sign up. Also check out http://evolvify.com/ I just found it and it's about physchology and evolution in relation to a paleo lifestyle/diet.

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by 240 · about 11 hours ago

I just wonder why it happens?

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Kashkillz 0 · December 06, 2012 at 10:06 PM

Kettlebell... squats... lunges... plyometrics... You are not a victim!!!

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by 213 · about 11 hours ago

Did you learn something that lead to a significant change in your daily routine? Do you think your health will be even better now that you have this new information? Do you trust the results? Do you think the science is too young to be... (more)

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balor123 0 · November 30, 2012 at 9:50 PM

I used 23andme and Promethease as well. I was having some difficult to diagnose health problems and I thought that the genetic tests might help me narrow down other tests to pursue. People usually focus on the disease risk factors but it's worth... (more)

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by 213 · September 30, 2014 at 3:50 AM

Is this done through one's doctor, or is there a more accurate genetic testing method that one's doctor might not be aware of? Is there a lab out there that studies this particular genetic condition that also offers testing to the public? I am... (more)

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JRM 0 · November 28, 2012 at 3:48 AM

23andme.com is probably cheaper than going to your doctor. I tested there and found out I don't carry the mutations.

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by 1186 · about 11 hours ago

Since a good part of the paleo rationale is based on the idea that we are not genetically adapted to eat a certain way, it seems very relevant and quite interesting to look at this example of how quickly such a genetic mutation/adaptation can... (more)

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Heidi_1 0 · October 24, 2012 at 6:39 PM

I remember studying this theory of evolution in grad school (my M.S. is in ecology and evolutionary biology) that talked about how evolution tended to happen in spurts. Tens of thousands or perhaps millions of years would go by with little change... (more)

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by 504 · September 29, 2014 at 3:45 AM

Since there is talk about gaining weight all over paleo hacks, i was wondering when played defensive end in high school when i weighed 240 (im 190 now) i was benching 325 for reps, powercleaning 260 for reps, and deadlifting 450-480 pounds, this... (more)

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paleohacks 0 · October 24, 2012 at 7:40 AM

For that type of very respectable performance most definitely genetics. There aren't too many 18 year olds benching 325 for reps without the gear, unless they've been dealt a good hand of genes. As always, be grateful to your parents :) (more)

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by 4181 · about 11 hours ago

I don't see my dad that much but when I did the other day I noticed that his skin is not great, my mum's seems ok but i think she wears foundation. My own skin is not great also, quite a few bumps and spots which don't really bother me too much... (more)

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miked_2 0 · August 07, 2012 at 9:29 PM

I'm firmly in the lifestyle camp. What I mean by that is that while your genes determine your potential, your lifestyle affects the expression of those genes (epigenetics). Your DNA is just a list of instructions for things, however whether or... (more)

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by 78407 · about 11 hours ago

You know those guys you see who are naturally muscular and barely lifts weights? How do you explain that? I kind of envy them. I have sucky genetics and have to work my ass off for every inch of muscle i gain. Thoughts?

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by 78407 · about 11 hours ago

Is it paleo to masturbate too much? Should i save my for loads for procreation purposes only? Will i ever get to pass my genes on?

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red_leaf 0 · August 06, 2012 at 1:22 AM

I know we like food and all but... don't feed the troll.

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by 72 · about 11 hours ago

My son (1.5yo) was just diagnosed with a very, very rare genetic disorder (Primary Hyperoxaluria Type III). The specialist who actually described this disease hypothesises that the genetic mutation causes the pathway for the proper breakdown of... (more)

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Matt_11 0 · July 28, 2012 at 12:24 PM

Not sure I understand how a vegan diet minimizes oxalates... which is the problem with hyperoxaluria. Oxalates are absent in animal products, and present in many plant foods. I'm guessing it stresses the kidneys so they're just trying to minimize... (more)

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by 801 · September 29, 2014 at 3:38 AM

As I understand the core argument for paleo, modern man retains what is essentially a 100,000-year old gene map, and many of our current health and psychological issues result from nutritional and behavioral departures from what Grok's genome was... (more)

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Mark_26 0 · July 18, 2012 at 9:33 PM

I would agree with the second paragraph that human beings are no longer evolving due to natural selection. The moment humans began adapting the environment to suit their needs they no longer adapted themselves to the environment. Essentially,... (more)

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by 413 · about 11 hours ago

Just to clarify, the title was just a way of posing this as a question. Obviously the NY times just report the news, so I don't hold them responsible for reporting this crap, but it was prescient enough and is trending on a prolific tech news... (more)

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paleohacks 0 · July 14, 2012 at 11:40 PM

This part is particularly troubling: "Did people unexpectedly gain or lose weight when they had the same amount of calories but in a diet of a different composition?" No. There was zero difference between high-fat and low-fat diets. Despite... (more)

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by 78407 · September 30, 2014 at 3:40 AM

Paleo is a wonderful notion - to emphasise the dietary practices that our bodies, due to evolution, are best suited to. This principle seems to work particularly well when compared with diet plans that are extremely unsuited to the expectations... (more)

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Shari_Bambino 0 · July 01, 2012 at 12:43 PM

As far as I can see we have already done that. Recreationists or the rigid thinkers are pretty much shunned as extremists which is as it should be IMO. It seems to me that most involved in the paleo movement are very sensitive to individual needs... (more)

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by 56596 · about 11 hours ago

I was talking with some relatives who have stomach problems and one thing I noticed is that a lot of them are on NSAIDs- ibuprofen and aspirin, for example. Over the years I have been on and off the paleo diet, but never gotten back to the point I... (more)

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Stephen_5 0 · June 23, 2012 at 2:48 PM

You wrote: The GI bleeding must just be the tip of the iceberg, there much be other damage occurring before it comes to that. Actually, GI bleeds are probably the initial and biggest side effect of NSAIDs. It happens very quickly, it... (more)

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by 1439 · September 30, 2014 at 3:38 AM

When we observe the diets of primitive tribes currently still in or close to the stone age, we see that they vary quite a bit. For example, the Kitava Island folks eat a lot of carbs (by our "paleo" standards), and the Inuit-like folks in north... (more)

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paleohacks 0 · May 28, 2012 at 5:34 PM

So what is the question?