Genetics

Genetics

Genetics Questions

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by 0 · about 7 hours ago

Hi, I have recently taken Genova's DetoxiGenomic Profile. Apparently I am absent of the GSTM! Glutathione gene. If glutathione supplementation is useless, what would you recommend I do? Regards, Neil.

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glutathione_pro 0 · November 01, 2013 at 12:13 AM

Glutathione supplementation is no longer useless. While most glutathione supplements are ineffective because they are broken down in the gut before they can be absorbed, you can overcome this. Either supplementing with the precursors of... (more)

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by 1336 · about 8 hours ago

We are our genes, but our genes are not our fate. As a paleo community we tend to concern ourselves greatly with our natural heritage, our predispositions and our gene expressions. We are very interested in bringing out the best of what we are and... (more)

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animalcule 0 · March 15, 2013 at 6:05 AM

Most things about the way any modern human looks are a mixture of genetics, epigenetics, and environment/nurture/'the kitchen'. This is certainly true of that particular anatomical feature. I'm not muscular (thin), don't have crazy low body fat,... (more)

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by 952 · about 8 hours ago

Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)

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Cave_Chick 0 · March 12, 2013 at 10:49 PM

According to 23andme I'm a 4/4 (and 3.1% Neanderthal!) and I notice MUCH better energy, cognition and fat loss when I eat large amounts of coconut oil daily. High quality coconut oil can be expensive, so at times I've stopped buying it to save... (more)

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by 952 · about 8 hours ago

For those who got APOE 4/4 result on genetic testing (http://snpedia.com/index.php/APOE). What have you learned during your experimentation with diet, supplementation and with overall lifestyle changes?

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Alex 0 · February 25, 2013 at 2:22 PM

I'm E4/E4. During my 20s and 30s, my diet was heavily influenced by Indian vegetarianism, with a heavy emphasis on grains and beans. This resulted in a flabby, lethargic descent into middle age. In September 2003, I drastically cut back on all... (more)

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by 631 · about 8 hours ago

Hey all, I need to do a genetics paper, and it's pretty free reign. This is the assignment: The Final Project A term paper is required. The term paper is due when you turn in your final assignment. Please submit the paper as a Microsoft Word... (more)

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David_Moss 0 · January 19, 2013 at 9:34 PM

How substantial the alteration of our genetics has been since the neolithic? I don't know whether that meets the remit or is too macro an issue. Consider this summary of the debate on wikipedia: According to Alexander Str??hle, Maike ... (more)

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by 298 · about 8 hours ago

I thought this might be of interest to some of the folks on here. It is a free online course offered by Duke University called "Introduction to Genetics and Evolution". https://www.coursera.org/course/geneticsevolution (more)

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willis0037 0 · August 08, 2013 at 9:29 AM

Thanks for sharing, I will definitely sign up. Also check out http://evolvify.com/ I just found it and it's about physchology and evolution in relation to a paleo lifestyle/diet.

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by 213 · about 8 hours ago

Is this done through one's doctor, or is there a more accurate genetic testing method that one's doctor might not be aware of? Is there a lab out there that studies this particular genetic condition that also offers testing to the public? I am... (more)

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JRM 0 · November 28, 2012 at 3:48 AM

23andme.com is probably cheaper than going to your doctor. I tested there and found out I don't carry the mutations.

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by 1186 · about 8 hours ago

Since a good part of the paleo rationale is based on the idea that we are not genetically adapted to eat a certain way, it seems very relevant and quite interesting to look at this example of how quickly such a genetic mutation/adaptation can... (more)

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Heidi_1 0 · October 24, 2012 at 6:39 PM

I remember studying this theory of evolution in grad school (my M.S. is in ecology and evolutionary biology) that talked about how evolution tended to happen in spurts. Tens of thousands or perhaps millions of years would go by with little change... (more)

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by 4181 · about 8 hours ago

I don't see my dad that much but when I did the other day I noticed that his skin is not great, my mum's seems ok but i think she wears foundation. My own skin is not great also, quite a few bumps and spots which don't really bother me too much... (more)

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miked_2 0 · August 07, 2012 at 9:29 PM

I'm firmly in the lifestyle camp. What I mean by that is that while your genes determine your potential, your lifestyle affects the expression of those genes (epigenetics). Your DNA is just a list of instructions for things, however whether or... (more)

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by 801 · about 8 hours ago

As I understand the core argument for paleo, modern man retains what is essentially a 100,000-year old gene map, and many of our current health and psychological issues result from nutritional and behavioral departures from what Grok's genome was... (more)

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Mark_26 0 · July 18, 2012 at 9:33 PM

I would agree with the second paragraph that human beings are no longer evolving due to natural selection. The moment humans began adapting the environment to suit their needs they no longer adapted themselves to the environment. Essentially,... (more)

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by 413 · about 8 hours ago

Just to clarify, the title was just a way of posing this as a question. Obviously the NY times just report the news, so I don't hold them responsible for reporting this crap, but it was prescient enough and is trending on a prolific tech news... (more)

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paleohacks 0 · July 14, 2012 at 11:40 PM

This part is particularly troubling: "Did people unexpectedly gain or lose weight when they had the same amount of calories but in a diet of a different composition?" No. There was zero difference between high-fat and low-fat diets. Despite... (more)

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by 78417 · about 8 hours ago

Paleo is a wonderful notion - to emphasise the dietary practices that our bodies, due to evolution, are best suited to. This principle seems to work particularly well when compared with diet plans that are extremely unsuited to the expectations... (more)

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Shari_Bambino 0 · July 01, 2012 at 12:43 PM

As far as I can see we have already done that. Recreationists or the rigid thinkers are pretty much shunned as extremists which is as it should be IMO. It seems to me that most involved in the paleo movement are very sensitive to individual needs... (more)

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by 56606 · about 8 hours ago

I was talking with some relatives who have stomach problems and one thing I noticed is that a lot of them are on NSAIDs- ibuprofen and aspirin, for example. Over the years I have been on and off the paleo diet, but never gotten back to the point I... (more)

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Stephen_5 0 · June 23, 2012 at 2:48 PM

You wrote: The GI bleeding must just be the tip of the iceberg, there much be other damage occurring before it comes to that. Actually, GI bleeds are probably the initial and biggest side effect of NSAIDs. It happens very quickly, it... (more)

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by 5002 · about 8 hours ago

I'll start with my question: Do you agree with Melissa McEwen's critique of Jack Kruse's (mis)use of evolutionary biology? I should note that I am a fan of both McEwen and Kruse. McEwen's blog post is... (more)

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Bread_Eating_Beelzebub 0 · April 02, 2012 at 3:34 AM

You have no idea how hard that post was to write. I mean, it's so hard to read Dr. Kruse's writing and find consistant threads in it. He has references on the bottom of some post, but mostly they do not correspond to things in his posts that I... (more)

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by 5509 · about 8 hours ago

I know that strict paleo doesn't include grains, dairy or legumes. However, I think the majority of people here are flexible with what they eat. Butter and cream seem to be sacred gods on this site. I was wondering if I could do some sort of poll... (more)

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Nance 0 · March 28, 2012 at 12:20 AM

I'd have to say many of my reactions to food would be compatible with a hunting/gathering ancestry. I hope you get lots of diverse responses. Russian, Polish and Scottish are my dominant ancestries. Experimentation and use of probiotics has... (more)

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by 691 · about 8 hours ago

If both your great-grandparents had a Paleo lifestyle and passed it down, how would your body fare today? Are we supposed to eat like our cultural ancestors or did your genetics get hampered because of some of the food they did or didn't eat?... (more)

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Tyler_2 0 · March 22, 2012 at 6:21 PM

In short, yes. Check out Deep Nutrition: Why Your Genes Need Traditional Food . Interesting read.

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by 2682 · about 8 hours ago

How much do you consider your family history (or gene testing, if you've done it) when making lifestyle decisions? For example, if you find out tomorrow that many of your older relatives had/have a particular cancer, would you begin to make... (more)

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Sarah_14 0 · February 27, 2012 at 7:00 PM

I don't consider myself a genetics expert, but I am married to one. Many people ask him if they should get tested for certain things, especially if they are adopted or have family history of cancer, etc. He will always say the same thing: "If... (more)

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by 871 · about 8 hours ago

I have a question that has been on my mind for a while now, and I am wondering what some other people think of this. So, having been strict Paleo for over a year now, that is my choice, I know that. my Significant other, is a wonderfully... (more)

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PrimalDanny 0 · February 22, 2012 at 12:09 AM

It may not be a helpful answer, but I'd really recommend trying to look beyond weight as the only measure of health. I'd also be cautious of drawing conclusions about what other people are eating or doing when you don't see them. I'm sure there... (more)

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by 952 · about 8 hours ago

Have you extracted any actionable, effective and yet counter-intuitive (to conventional wisdom and general paleo knowledge) conclusions from 23andme or other genetic testing companies?

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Dorado_Galore 0 · February 15, 2012 at 8:24 PM

You probably are not looking for grounds upon which to sue 23andme, but... The word "actionable" means "affording grounds for legal action" and "violating principles of justice." I get that you mean something closer to: "Based on one's genome,... (more)

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by 1436 · about 8 hours ago

I recently found out (from 23andme) that I am heterogeneous (one copy of the "bad" gene) for the MTHFR C677T polymorphism. This means that my body has reduced ability to convert folate into the active form of folate (5-methyltetrahydrafolate).... (more)

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esque 0 · October 21, 2011 at 9:24 AM

I discovered I had this gene (hetero like you) on 23andme and started taking the active folate. Then I had a blood test and my folate was absurdly high. I have sinced eased off on the supplementation as in spite of my wack gene, I seem to be... (more)

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by 888 · about 8 hours ago

I found this article today. Basically Australian scientists have isolated a gene (ld1) that regulates the function of beta cells in mice, affecting their ability to properly excrete insulin. "Fat in the diet also switches on the gene as well as... (more)

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Jay_15 0 · October 01, 2011 at 3:00 PM

They come out with a new "master gene" for a new disease process every other day. I don't really put much stock into it. As far as the lower fat and carbohydrate part of the diet, then what would they suggest we eat? Gotta have at least a... (more)

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by 1072 · about 8 hours ago

Loaded question I know, but this is a really interesting piece on DNA being changed by the foods we eat. We Incorporate Genetic Information From the Food We Eat, New Study Finds

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paleohacks 0 · September 22, 2011 at 11:59 AM

DNA is not being changed, you read it wrong and the title is stupid. Its about miRNAs, very short nucleotide sequences that suppress specific gene. So you may get your DNA expression changed for some short time since miRNAs are degraded by the... (more)

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by 18412 · about 8 hours ago

I have a large family. I have always been very influential in my family, especially with my brothers and sisters. I am also the most fit and perceived as the most "healthy" (it's very difficult for me to say that at the moment) amongst my... (more)

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Tom_R_ 0 · September 15, 2011 at 5:44 PM

First, I would ask the question: do the pros of leading your siblings down the road you have gone (i.e. getting in shape and "ripped" with the resulting other effects) outweigh the cons (i.e. remaining overweight)? Put another way, is presuming... (more)

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by 1186 · about 8 hours ago

Pyroluria-- Is it real? Is it permanent? Those that pay attention to it regard it as genetic, requiring permanent B6 supplementation. Nora Gedgaudas in "Primal Mind Primal Body" has a whole appendix on it and seems to share this view. Any... (more)

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Harry_3 0 · May 16, 2012 at 10:56 AM

Oh its real alright. I have Pyroluria, it took me 8 years to work out what caused all my symptoms, these symptoms included: Brain fog Poor concentration and memory Depression Anxiety Chronic fatigue (really adrenal fatigue) Digestive... (more)

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by 4080 · about 8 hours ago

EDIT: Other PH posts are slightly different: My post is about my specific results. I took this genetic test because I am at the bottom of the barrel as far as stuff to try for my health issues. So help me with a little speculation on trying to... (more)

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Amy_10 0 · September 12, 2011 at 10:15 PM

Senneth, Your tummy problems may be covering up your ability to have high iron. If your diarrhea dominant, your iron may be just running out of you. If your constipated your iron levels should hypothetically be higher. Generally, people who are... (more)

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