Genetics

Genetics

Genetics Questions

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by 1336 · about 16 hours ago

I've been researching celiac disease a ton over the past few days since getting my 23andme results back. It's a very confusing tangle of genes, but it looks like I'm heterozygous for the "celiac genes", both HLA-DQ2 (2.5, but not 2.2) and HLA-DQ8.... (more)

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Sara_S_ 0 · July 06, 2013 at 8:08 PM

Do you have any relatives with celiac disease? I personally think it's a good idea to get tested before going gluten free, as many people are asymptomatic. I think most doctors aren't keen to test you unless you either have symptoms of celiac... (more)

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by 0 · about 16 hours ago

Hi, I have recently taken Genova's DetoxiGenomic Profile. Apparently I am absent of the GSTM! Glutathione gene. If glutathione supplementation is useless, what would you recommend I do? Regards, Neil.

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glutathione_pro 0 · November 01, 2013 at 12:13 AM

Glutathione supplementation is no longer useless. While most glutathione supplements are ineffective because they are broken down in the gut before they can be absorbed, you can overcome this. Either supplementing with the precursors of... (more)

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by 952 · about 16 hours ago

Anyone tried it? What is better NAC or gluthaionine? I found this interesting paper which supports supplementation with NAC and couple of other gluthaionine precursors: http://www.ncbi.nlm.nih.gov/pubmed/17914184 Any APOE 4/4 who actually tried... (more)

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by 952 · about 16 hours ago

Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)

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Cave_Chick 0 · March 12, 2013 at 10:49 PM

According to 23andme I'm a 4/4 (and 3.1% Neanderthal!) and I notice MUCH better energy, cognition and fat loss when I eat large amounts of coconut oil daily. High quality coconut oil can be expensive, so at times I've stopped buying it to save... (more)

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by 952 · about 16 hours ago

For those who got APOE 4/4 result on genetic testing (http://snpedia.com/index.php/APOE). What have you learned during your experimentation with diet, supplementation and with overall lifestyle changes?

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Alex 0 · February 25, 2013 at 2:22 PM

I'm E4/E4. During my 20s and 30s, my diet was heavily influenced by Indian vegetarianism, with a heavy emphasis on grains and beans. This resulted in a flabby, lethargic descent into middle age. In September 2003, I drastically cut back on all... (more)

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by 631 · about 16 hours ago

Hey all, I need to do a genetics paper, and it's pretty free reign. This is the assignment: The Final Project A term paper is required. The term paper is due when you turn in your final assignment. Please submit the paper as a Microsoft Word... (more)

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David_Moss 0 · January 19, 2013 at 9:34 PM

How substantial the alteration of our genetics has been since the neolithic? I don't know whether that meets the remit or is too macro an issue. Consider this summary of the debate on wikipedia: According to Alexander Str??hle, Maike ... (more)

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by 240 · about 16 hours ago

I just wonder why it happens?

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Kashkillz 0 · December 06, 2012 at 10:06 PM

Kettlebell... squats... lunges... plyometrics... You are not a victim!!!

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by 213 · about 16 hours ago

Did you learn something that lead to a significant change in your daily routine? Do you think your health will be even better now that you have this new information? Do you trust the results? Do you think the science is too young to be... (more)

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balor123 0 · November 30, 2012 at 9:50 PM

I used 23andme and Promethease as well. I was having some difficult to diagnose health problems and I thought that the genetic tests might help me narrow down other tests to pursue. People usually focus on the disease risk factors but it's worth... (more)

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by 504 · about 16 hours ago

Since there is talk about gaining weight all over paleo hacks, i was wondering when played defensive end in high school when i weighed 240 (im 190 now) i was benching 325 for reps, powercleaning 260 for reps, and deadlifting 450-480 pounds, this... (more)

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paleohacks 0 · October 24, 2012 at 7:40 AM

For that type of very respectable performance most definitely genetics. There aren't too many 18 year olds benching 325 for reps without the gear, unless they've been dealt a good hand of genes. As always, be grateful to your parents :) (more)

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by 78422 · about 16 hours ago

You know those guys you see who are naturally muscular and barely lifts weights? How do you explain that? I kind of envy them. I have sucky genetics and have to work my ass off for every inch of muscle i gain. Thoughts?

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by 78422 · about 16 hours ago

Is it paleo to masturbate too much? Should i save my for loads for procreation purposes only? Will i ever get to pass my genes on?

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red_leaf 0 · August 06, 2012 at 1:22 AM

I know we like food and all but... don't feed the troll.

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by 72 · about 16 hours ago

My son (1.5yo) was just diagnosed with a very, very rare genetic disorder (Primary Hyperoxaluria Type III). The specialist who actually described this disease hypothesises that the genetic mutation causes the pathway for the proper breakdown of... (more)

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Matt_11 0 · July 28, 2012 at 12:24 PM

Not sure I understand how a vegan diet minimizes oxalates... which is the problem with hyperoxaluria. Oxalates are absent in animal products, and present in many plant foods. I'm guessing it stresses the kidneys so they're just trying to minimize... (more)

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by 413 · about 16 hours ago

Just to clarify, the title was just a way of posing this as a question. Obviously the NY times just report the news, so I don't hold them responsible for reporting this crap, but it was prescient enough and is trending on a prolific tech news... (more)

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paleohacks 0 · July 14, 2012 at 11:40 PM

This part is particularly troubling: "Did people unexpectedly gain or lose weight when they had the same amount of calories but in a diet of a different composition?" No. There was zero difference between high-fat and low-fat diets. Despite... (more)

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by 78422 · about 16 hours ago

Paleo is a wonderful notion - to emphasise the dietary practices that our bodies, due to evolution, are best suited to. This principle seems to work particularly well when compared with diet plans that are extremely unsuited to the expectations... (more)

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Shari_Bambino 0 · July 01, 2012 at 12:43 PM

As far as I can see we have already done that. Recreationists or the rigid thinkers are pretty much shunned as extremists which is as it should be IMO. It seems to me that most involved in the paleo movement are very sensitive to individual needs... (more)

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by 1439 · about 16 hours ago

When we observe the diets of primitive tribes currently still in or close to the stone age, we see that they vary quite a bit. For example, the Kitava Island folks eat a lot of carbs (by our "paleo" standards), and the Inuit-like folks in north... (more)

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paleohacks 0 · May 28, 2012 at 5:34 PM

So what is the question?

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by 0 · about 17 hours ago

I'm being hopeful... This is a long shot and I'm pretty sure nobody will answer...but is there anyone with NF out there who is on paleo? Do you think that it will help with any of the symptoms? Thanks in advance.

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LaurenM 0 · April 15, 2012 at 9:54 AM

You have probably already found this, but the only lead I could find (hopefully more knowledgeable people can either discredit or use as a springboard) was here:... (more)

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by 5002 · about 17 hours ago

I'll start with my question: Do you agree with Melissa McEwen's critique of Jack Kruse's (mis)use of evolutionary biology? I should note that I am a fan of both McEwen and Kruse. McEwen's blog post is... (more)

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Bread_Eating_Beelzebub 0 · April 02, 2012 at 3:34 AM

You have no idea how hard that post was to write. I mean, it's so hard to read Dr. Kruse's writing and find consistant threads in it. He has references on the bottom of some post, but mostly they do not correspond to things in his posts that I... (more)

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by 5509 · about 17 hours ago

I know that strict paleo doesn't include grains, dairy or legumes. However, I think the majority of people here are flexible with what they eat. Butter and cream seem to be sacred gods on this site. I was wondering if I could do some sort of poll... (more)

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Nance 0 · March 28, 2012 at 12:20 AM

I'd have to say many of my reactions to food would be compatible with a hunting/gathering ancestry. I hope you get lots of diverse responses. Russian, Polish and Scottish are my dominant ancestries. Experimentation and use of probiotics has... (more)

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by 203 · about 17 hours ago

Hi! Because of constipation, which is now better, my G.I specialist got me to take a blood test to see if I have celiac or not. The results were that I'm a carrier for Celiac disease but it came back negative. My aunt didnt develop properly... (more)

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Mscott 0 · March 24, 2012 at 3:07 AM

If you haven't been eating gluten leading up to the blood test the ability of the test to identify celiac disease drops considerably. I know someone who stopped eating gluten, felt much much better, then went to the doctor a few weeks later to be... (more)

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by 871 · about 17 hours ago

I have a question that has been on my mind for a while now, and I am wondering what some other people think of this. So, having been strict Paleo for over a year now, that is my choice, I know that. my Significant other, is a wonderfully... (more)

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PrimalDanny 0 · February 22, 2012 at 12:09 AM

It may not be a helpful answer, but I'd really recommend trying to look beyond weight as the only measure of health. I'd also be cautious of drawing conclusions about what other people are eating or doing when you don't see them. I'm sure there... (more)

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by 1072 · about 17 hours ago

Loaded question I know, but this is a really interesting piece on DNA being changed by the foods we eat. We Incorporate Genetic Information From the Food We Eat, New Study Finds

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paleohacks 0 · September 22, 2011 at 11:59 AM

DNA is not being changed, you read it wrong and the title is stupid. Its about miRNAs, very short nucleotide sequences that suppress specific gene. So you may get your DNA expression changed for some short time since miRNAs are degraded by the... (more)

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by 1186 · about 17 hours ago

Pyroluria-- Is it real? Is it permanent? Those that pay attention to it regard it as genetic, requiring permanent B6 supplementation. Nora Gedgaudas in "Primal Mind Primal Body" has a whole appendix on it and seems to share this view. Any... (more)

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Harry_3 0 · May 16, 2012 at 10:56 AM

Oh its real alright. I have Pyroluria, it took me 8 years to work out what caused all my symptoms, these symptoms included: Brain fog Poor concentration and memory Depression Anxiety Chronic fatigue (really adrenal fatigue) Digestive... (more)

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by 5002 · about 17 hours ago

I've always wondered if the different levels in carb tolerance that we often see has anything to do with genetic differences that related to ethnicity. I, for example, am half Italian (mother born there) and half Jewish-Russian (perhaps Belarus;... (more)

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Andy 0 · August 03, 2011 at 1:21 AM

Scotch/Irish and Seminole/Cherokee... very sensitive to carbs. I get fat easily if I eat too many, my blood sugar gets too high. Even when it comes to alcohol, I simply cannot tolerate it. 2 drinks and I'm done. But on the reservation, the... (more)

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by 50 · about 17 hours ago

The show is about how we all started in Africa and migrated north then one group heads west and another group goes east. We lightened up the further north we went to be able to get the most amount of Vit D with shorter days I guess. But then how... (more)

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Bisous_1 0 · November 13, 2010 at 5:24 PM

There's also evidence that European light skin and different colors of hair might have a lot to do with sexual selection in addition to issues with vitamin D.

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by 20411 · about 17 hours ago

Was wondering what the survival advantage could have been and came across this paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917125/?tool=pubmed (full free text) From the abstract: "All humans are double knockouts. Humans lack the... (more)

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Levi 0 · October 28, 2010 at 9:09 PM

Good question. I've heard that it was a genetic mutation that we eventually were able to adapt to with diet. The other option is that because of our self-selected diet the ability to synthesize C was not preserved because it wasn't as needed. Gary... (more)

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