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Diamine oxidase for histamine intolerance?

by (424)
Updated 8 minutes ago
Created March 14, 2012 at 5:45 PM

Does anyone have any experience with, or thoughts on, taking diamine oxidase (DAO) supplements to combat histamine intolerance? I believe 'Histame' is the brand available in the US and UK. I'm thinking of trying these to reduce my reactions to high-histamine foods while I attempt to heal my gut but they're incredibly expensive. I'm also trying to reduce the histamine in my diet but am finding this difficult for various reasons.

Thanks!

Background: I'm male, 28 with a 20+ year history of wacky digestion and other health problems. Been strict, nightshade-free Paeleo since November with moderate improvement in symptoms. Tested negative for Coeliac, Crohns, Colitis, bowel cancer, diabetes and thyroid problems: my colorectal specialist described me as 'a mystery'. Am currently eating very low carb as I swell up like a balloon, belch uncontrollably and lose weight like crazy whenever I eat any carbs (still trying to get tested for SIBO - virtually nowhere in the UK will test for this - argh!).

Anyway, since going VLC I've reduced the bloating and weight loss but have started noticing reactions to foods such as chicken, spinach, salmon, nuts (diarrhoea, itching, flushing, sinus problems, palpitations etc.), hence I'm suspecting an additional histamine intolerance on top of all the other mess. I can't cut much more out of my diet or there will be nothing left (of the diet or of me). It's all driving me nuts. Any help much appreciated!

Update: I decided not to purchase the DAO in the end and started the GAPS diet instead. I felt that the DAO wasn't going to address the root cause of my problems and wasn't worth the expense.

My experience on GAPS has been mixed so far. I took more probiotic tablets in the beginning but I'm gradually replacing these with fermented foods. After slowly introducing the broths and probiotics I'm tolerating amines better than I used to. However, I've had other issues surface (especially skin problems of various kinds). I'm hoping these are 'die-off' and a good sign, but it's too early to tell.

Update 2: Spoke too soon about the amine tolerance! I'm experiencing major amine intolerance symptoms again. I'm drinking a lot more kefir than before which isn't helping, although it's the only thing that's had an impact on my fungal problems and eczema so I'm reluctant to give up drinking it at present. I've caved in and ordered the DAO. I'll report back when I've had chance to try it.

54065d11ced1510973bde69f6ed50882
0 · September 21, 2014 at 11:02 PM

Hi TJ,

From the symptoms you describe, it sounds as if you have a pretty serious case of Histamine Intolerance (HIT). As you already know, this under-recognised disease occurs when the body is deficient in DAO enzymes, the agents that break down histamine. With excessive histamine circulating through the bloodstream to every part of the body, symptoms can manifest in a wide variety of ways including digestive disorders, headaches, sleep disorders, anxiety, heartburn, depression, hives and other skin problems - the list goes on.

There are several ways to combat HIT including -

* Following a striclty low histamine diet for 4 - 6 weeks, after which you may gradually re-introduce
the foods you normally eat

* Taking certain vitamin, mineral and other supplements to boost the effectiveness of the diet

* Healing the gut where DAO is produced, to increase your own natural DAO production

* Taking daily doses of DAO in a natural (and inexpensive) form by juicing young pea sprouts that have been grown in the dark

* Taking commercial products such as DAOsin and Histame

There is a wealth of further information on the topic at the website low-histamine dot com (Paleohacks wont let me add a link until I have 30 points!)
The book "Is Food Making You Sick?" includes much more information plus low histamine/amine/salicylate recipes.

Stress can be one of the many underlying causes of HIT, so take it easy and I wish you good health!

Sue

E246df7366ba4b48f75b53378ed33282
424 · September 07, 2013 at 1:28 AM

Did this work? I've not heard of echinacea being used as an antihistamine before. I've taken it before for other problems but can't say I noticed it made a difference to my histamine symptoms.

E246df7366ba4b48f75b53378ed33282
424 · November 27, 2012 at 12:59 PM

Thanks for sharing your experience Tess. Glad you've found some relief from using the betaine HCl - sounds like your problem could be linked to low stomach acid. I've tried the betaine HCl for months at a time but sadly it does nothing for me.

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424 · November 12, 2012 at 5:50 PM

Hi Carolyn. Antihistamines like Benedryl don't actually reduce the histamine load in the body. They just block certain histamine receptors in the body. They mask some of the symptoms but don't do anything to solve the underlying problem. They might help on a short-term basis if the symptoms are very bad but they'll do nothing for you in the long term. (In a way the DAO is a bit like this too but at least in theory, it's reducing the total amount of histamine in the body).

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424 · October 06, 2012 at 2:01 PM

I've tried it several times but I honestly can't say whether it's working or not. I had a massive flare up of symptoms a few weeks back and I'm still all over the place. I'm not sure it's having much of an effect - it's certainly not a miracle cure anyway. I've started the taking the supplements mentioned by SunnyCo above and I think they're having more of an effect than the DAO, but it's too early to come to a firm conclusion.

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424 · October 04, 2012 at 10:48 AM

Funnily enough, I'm just starting a similar regime. Are you taking the methyl form of B6 and B12 as well? And how do you get your Inositol and Choline? I'm taking a sunflower lecithin supplement - would that do? Sorry for all the questions - I'm desperate to get this sorted! Haven't tested the DAOSin properly yet as the mail order company had run out when I ordered it and it's only just been delivered to me. Thanks for your advice!

E246df7366ba4b48f75b53378ed33282
424 · July 25, 2012 at 1:21 PM

I guess I'm lucky that my histamine problems aren't as severe as some people's. I think I have some sort of small bowel bacterial/yeast overgrowth, and keeping this in check with low carb/low FODMAP helps with the histamine problem. I still get issues if I eat too many histamine rich foods on consecutive days, but not as bad as before. I've also been taking vitamin C (as ascorbic acid) with potentially problematic meals and milk thistle extract. I can't say that one thing in particular has 'worked' but the combination of things is having some effect.

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424 · July 25, 2012 at 1:16 PM

I had problems initially, but I concentrated on the broths and fresh meats first (with very limited veggies) trying to make the diet as low in histamine as I could. I stuck mostly with fresh lamb and beef, avoiding pork and fish and only adding chicken occasionally. I also took l-glutmaine to supplement the broths, which luckily, I tolerated ok. At first I just had probiotic capsules (BioKult, then added a Saccharomyces Boulardii supplement). I didn't add the fermented foods in until later, and then starting with small amounts and gradually building up.

22fd82abf435768244f8d074430cd1e6
580 · July 25, 2012 at 12:36 PM

I am really wondering how you manage with the GAPS, given the fact that fermented foods are so high in histamine. Do you react to broth etc ?

E246df7366ba4b48f75b53378ed33282
424 · July 25, 2012 at 11:34 AM

I don't know your personal circumstances but the DAO could give you some breathing space, if it works for you. The product reviews on Amazon/iHerb suggest that it helps some people but not others. Longer term, I'd recommend looking into a gut healing protocol. I'm afraid I can't give you much advice at the moment. I'm out of the trenches but still bogged down in no-man's land. All the best in addressing your amine intolerance. If you have any success please share too!

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424 · July 25, 2012 at 11:26 AM

Hi wormgirl1. I didn't purchase the DAO in the end. I decided it was just a 'sticking plaster' that didn't properly address my digestive issues so I'm trying a GAPS-diet-type approach to sort out the gut dysbiosis which I believe is at the root of all this mess. I've posted a few updates on here but they're buried in the comments. I'll add a proper update onto the end of the question so it's easier for people to find.

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367 · July 12, 2012 at 4:53 PM

and I also recommend that if you get to a point where things are going well (coconut oil -used to- keep my eczema in check until I became hugely intolerant of it) - get out while the going's good and stop. Then if symptoms reappear, maybe do another brief period of antifungals, but don't do them continuously and indefinitely. Another thing that seems to help me is Lugol's iodine, which is not only a needed nutrient but a disinfectant.

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:49 PM

loaded with yeast, so I have zero tolerance of it (I feel like I have the flu when I try it). If yogurt is giving you eczema, I would say - don't do it. Kefir's burping and bloating symptoms for you also suggest that its yeast is filling you up with carbon dioxide. If you want to introduce good bacteria and kill the bad guys, I suggest dairy-free probiotics, avoiding all dairy, and then temporary/intermittent dosing of antifungals. Garlic is usually my go-to (I am sensitive to it but only do it once in awhile), but you can also try medium chain triglycerides (again, I suggest periodic doses)

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:45 PM

-- if you're going to do them, do it only temporarily at a tolerably low level to repopulate the gut and kill bad guys with lactic acid. Beyond temporary gut repopulation, my sense is that fermented foods just continually introduce more histamine and yeast to a system that can't handle it. In my exploration of my own intolerances, high-histamine foods are the worst - so yogurt, unpasteurized sauerkraut, cheese, beer, etc. - these things just about kill me in varying degrees. I high slightly increased tolerance now, but I still avoid these things as much as possible. And kefir is absolutely

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:41 PM

Interesting - I tend to associate burping with disruption/increase of gut flora/yeast (carbon dioxide production) though I don't know if it can indicate yeast death. That's what you want of course but my feeling now is that if something is making you feel bad for more than a few days, stop taking it. Maybe try again later but it might just be a sign that it's bad for you. (I used to override those feelings and now I'm worse off than I should be, I think.) While everyone says GAPS is great, I'm not a fan. As a histamine-intolerant person I think that fermented foods are NOT the way to go (con't

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424 · July 10, 2012 at 2:37 PM

Update: I tried the raw garlic but it made me burp like crazy (fructans?). I stuck at it for over a week but didn't see much improvement. Have started having fermented goats milk dairy (as per GAPS). Yoghurt gives me eczema flares. Kefir doesn't affect my skin as much but gives me burping, bloating and huge stools. :-(

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424 · May 04, 2012 at 12:23 PM

Hi CharlieMezak. I decided not to purchase the Histame and instead I've gone for full GAPS. I started about 3 weeks ago and I'm about half way through the intro diet at the moment. My symptoms are fluctuating a lot but I think my sensitivity has improved a little. I started taking Saccharomyces Boulardii probiotic last week. The die-off is quite intense but I think this is helping too. Best of luck - do try GAPS. Let me know if I can give you any more info. It can be really overwhelming so it's good to know you're not alone!

Ded84388fef90e4209cf9520d1456a95
520 · April 11, 2012 at 6:20 PM

@TJ. Wow, I'm 28 and am dealing with a remarkably similar situation to that which you describe. I'd love to hear about your experience and progress. Did you end up trying Histame? I'm hoping to start a GAPS campaign soon. Don't know if that will resolve the histamine sensitivity, but hoping it will help somewhat.

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367 · March 16, 2012 at 6:25 PM

Could explain my terrible reaction to Histame? Interesting. Or it's the fillers, as StreakofLean mentions, or, who knows.

7636e1e02ef91a46f20a42e07b565a4b
367 · March 15, 2012 at 8:15 PM

TJ, yeah, it's just one thing in a long list of things that hasn't worked so I'm getting used to it ;) but I wouldn't give up. I keep tweaking things and end up with subtle improvements at least. I definitely recommend the raw garlic but you might want to start with little and build up in case you have a strong reaction. Do you eat dairy?

C56baa1b4f39839c018180bf63226f7d
3499 · March 15, 2012 at 5:53 PM

Agreed with that. TJ's proposal is the way to go regardless of the cause.

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424 · March 15, 2012 at 4:13 PM

I suppose it's theoretically possible to produce antibodies to an enzyme (they are proteins after all) although I've no idea how likely this is in practice. I think trying to heal the gut and correct any imbalances in intestinal flora is probably the best practical way to deal with intolerances.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 4:04 PM

DAOSin is cheaper than Histame but it looks as though the tablets have more fillers so I'll probably go with the Histame. Incidentally, I've just found this, not very scientific anecdotal study on DAOSin done by Allergy UK and the manufacturer (http://forum.allergyuk.org/viewtopic.php?f=11&t=1568&p=6533&hilit=DAOSin#p6533). Looks like it helps with some symptoms more than others. I've found mixed reports about Budka on the web and I don't think I can afford to visit him anyway. Looks like I'm going to have to take the plunge and go for the GAPS diet.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 4:03 PM

DAOSin is cheaper than Histame but it looks as though the tablets have more fillers so I'll probably go with the Histame. Incidentally, I've just found this, not very scientific on DAOSin done by Allergy UK and the manufacturer. Looks like it helps with some symptoms more than others. I've found mixed reports about Budka on the web and I don't think I can afford to visit him anyway. Looks like I'm going to have to take the plunge and go for the GAPS diet.

E246df7366ba4b48f75b53378ed33282
TJ_5 424 · March 15, 2012 at 4:01 PM

DAOSin is cheaper than Histame but it looks as though the tablets have more fillers so I'll probably go with the Histame. Incidentally, I've just found this, not very scientific anecdotal study on DAOSin done by Allergy UK and the manufacturer. Looks like it helps with some symptoms more than others. I've found mixed reports about Budka on the web and I don't think I can afford to visit him anyway. Looks like I'm going to have to take the plunge and go for the GAPS diet.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 12:26 PM

Sorry the DAO didn't work for you, ddibwynt. I think I might order it anyway and give it a shot. I've not got much to lose. Like you, I'm thinking these kind of intolerances are linked to gut dysbiosis as the wrong mix of gut flora produce toxins and impede normal digestion and enzyme secretion. I did take a course of antifungal medication about 6 months back (prescribed by my GP for a skin condition) but it didn't help my digestion, so I'm thinking the problem is most likely bacterial. I'm going to give the raw garlic a shot anyway.

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424 · March 15, 2012 at 12:15 PM

Thanks, PaleoGran - those links are brilliant. I'm going to try the FailSafe diet as I can certainly identify with several of the food reactions on there (I get a drug-like 'high' from A1 milk so there's definitely opiate/food chemical thing going on somewhere).

D31a2a2d43191b15ca4a1c7ec7d03038
4124 · March 14, 2012 at 9:24 PM

TJ, I wish I could answer your question. I too, went low FODMAP, which helped greatly. I also did the FailSafe elimination diet and eliminated some other foods. Here is a blog which tells about FailSafe: http://failsafediet.wordpress.com/ Also, PFW's experience with Crohn's might be of interest. Here is his blog: http://crohnscarnivore.blogspot.com/ and PaleoPhil's blog, too: http://ancestrallifestyle.blogspot.com/ You could check with Jamie Scott at Paleo Guy for DAO information: http://thatpaleoguy.com/ I wish you success. :)

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7636e1e02ef91a46f20a42e07b565a4b
1
367 · March 15, 2012 at 12:08 AM

TJ, my n=1 will not be very encouraging, unfortunately, but I have intolerances up the yin-yang so I imagine most probably write me off as an outlier. In any case, I'm certain I have histamine intolerance and did try Histame, or DAO. Disappointingly I felt like I had the flu a few hours later. I tried it again with much trepidation... had the same reaction. I really wish it had worked, as beer, wine, etc. are sorely missed. However, as PaleoGran mentioned, other allergies/intolerances can be at play. That may even be why I reacted poorly to the Histame - I have a problem with amines, along with phenols and other chemicals that are detailed to some extent by the Failsafe diet. I believe Histame's DAO is from dessicated pig kidneys (?) which would likely make it high in amines; this could have caused my flu-like reaction. However, if you can afford to risk it, it's worth a shot. Sounds like some people benefit from this stuff.

Also, if you have a lot of bloating from carbs I'd imagine you might have yeast overgrowth and might want to look into some antifungals. Raw garlic, food-grade hydrogen peroxide, iodine, medium chain triglycerides, probiotics, etc. might help. I have a hunch that histamine intolerance follows gut dysbiosis and yeast overgrowth because these organisms produce histamine, so treating that problem should help ease the allergen load and improve tolerance. I'm still intolerant - even years after getting my system in check - and doubt it will ever go away, but it was MUCH worse when I had unbalanced gut flora.

7636e1e02ef91a46f20a42e07b565a4b
367 · March 15, 2012 at 8:15 PM

TJ, yeah, it's just one thing in a long list of things that hasn't worked so I'm getting used to it ;) but I wouldn't give up. I keep tweaking things and end up with subtle improvements at least. I definitely recommend the raw garlic but you might want to start with little and build up in case you have a strong reaction. Do you eat dairy?

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424 · March 15, 2012 at 12:26 PM

Sorry the DAO didn't work for you, ddibwynt. I think I might order it anyway and give it a shot. I've not got much to lose. Like you, I'm thinking these kind of intolerances are linked to gut dysbiosis as the wrong mix of gut flora produce toxins and impede normal digestion and enzyme secretion. I did take a course of antifungal medication about 6 months back (prescribed by my GP for a skin condition) but it didn't help my digestion, so I'm thinking the problem is most likely bacterial. I'm going to give the raw garlic a shot anyway.

E246df7366ba4b48f75b53378ed33282
424 · July 10, 2012 at 2:37 PM

Update: I tried the raw garlic but it made me burp like crazy (fructans?). I stuck at it for over a week but didn't see much improvement. Have started having fermented goats milk dairy (as per GAPS). Yoghurt gives me eczema flares. Kefir doesn't affect my skin as much but gives me burping, bloating and huge stools. :-(

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:53 PM

and I also recommend that if you get to a point where things are going well (coconut oil -used to- keep my eczema in check until I became hugely intolerant of it) - get out while the going's good and stop. Then if symptoms reappear, maybe do another brief period of antifungals, but don't do them continuously and indefinitely. Another thing that seems to help me is Lugol's iodine, which is not only a needed nutrient but a disinfectant.

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:41 PM

Interesting - I tend to associate burping with disruption/increase of gut flora/yeast (carbon dioxide production) though I don't know if it can indicate yeast death. That's what you want of course but my feeling now is that if something is making you feel bad for more than a few days, stop taking it. Maybe try again later but it might just be a sign that it's bad for you. (I used to override those feelings and now I'm worse off than I should be, I think.) While everyone says GAPS is great, I'm not a fan. As a histamine-intolerant person I think that fermented foods are NOT the way to go (con't

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:45 PM

-- if you're going to do them, do it only temporarily at a tolerably low level to repopulate the gut and kill bad guys with lactic acid. Beyond temporary gut repopulation, my sense is that fermented foods just continually introduce more histamine and yeast to a system that can't handle it. In my exploration of my own intolerances, high-histamine foods are the worst - so yogurt, unpasteurized sauerkraut, cheese, beer, etc. - these things just about kill me in varying degrees. I high slightly increased tolerance now, but I still avoid these things as much as possible. And kefir is absolutely

7636e1e02ef91a46f20a42e07b565a4b
367 · July 12, 2012 at 4:49 PM

loaded with yeast, so I have zero tolerance of it (I feel like I have the flu when I try it). If yogurt is giving you eczema, I would say - don't do it. Kefir's burping and bloating symptoms for you also suggest that its yeast is filling you up with carbon dioxide. If you want to introduce good bacteria and kill the bad guys, I suggest dairy-free probiotics, avoiding all dairy, and then temporary/intermittent dosing of antifungals. Garlic is usually my go-to (I am sensitive to it but only do it once in awhile), but you can also try medium chain triglycerides (again, I suggest periodic doses)

Ab35f73aec7caa4b390ab6f9b91305ab
2
20 · October 03, 2012 at 6:49 PM

Has anyone tried TMG, Folate (NOT folic acid it MUST be L-methylfolate-Metafolin) B6, B12, Inositol and Choline? Those are the classic supplement combinations for treating histamine issues. After 11 years of doctor to doctor, test after test, I self diagnosed myself to one of the 30% of the population who have the inabilty to convert Folic acid to the methyl doner needed to break down histamine. Has worked like a charm and was almost instant relief from the first dose! These supplements are a HECK of a lot cheaper than the DAO supplement on Amazon.

Good luck to eveyone!!

E246df7366ba4b48f75b53378ed33282
424 · October 04, 2012 at 10:48 AM

Funnily enough, I'm just starting a similar regime. Are you taking the methyl form of B6 and B12 as well? And how do you get your Inositol and Choline? I'm taking a sunflower lecithin supplement - would that do? Sorry for all the questions - I'm desperate to get this sorted! Haven't tested the DAOSin properly yet as the mail order company had run out when I ordered it and it's only just been delivered to me. Thanks for your advice!

C760fefc0afe815d7b057bafc8ef20fc
1
10 · May 22, 2013 at 7:26 PM

ive noticed there was a person above who mentioned a gene responsible for making the DAO enzyme that degrades histamine.we did a 23 and me gene test on some of us and i found that two of my kids have double defects on that gene snp. meaning theyre likely to have histamine issues because theyre lacking enough DAO becuase of the defect. i recently bought a supplement called DAOSin from swanson vitamins that is showing some great progress for my daughter who has POTS (which seems like a histamine issue to begin with which turns into possible mast cell issues and then eventuallly POTS. she cant ever make her body produce that enzyme on its own so taking it and watching her histamine intake seemed the next best thing for us.

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1
10 · April 21, 2013 at 4:51 PM

Hello Everyone, I'm new to this site and have been reading all your messages. I recently was diagnosed with Rheumatoid arthritis after rupturing 2 tendons in my hand. Through that process they have discovered that I have a histamine intolerance. I've been seeing a rheumatologist and a nutritionist associated with his office.

In addition to all the RA drugs I'm on, the nutritionist has put me on a low histamine diet to reduce inflammation and swelling. I see most of you have talked about Histame which is quite expensive. I thought you might be interested in what she suggested.

She said to take N-Acetyl Cysteine (NAC): 500mg twice per day with meals. Can increase to 3,000mg in divided doses, as tolerated. I've just found several brands on Drugstore.com and they seem very reasonable in cost.

In addition she said to add Diamine Oxidase (DAO) with higher histamine meals; taking it 20 minutes before the meal.

I'm thinking this protocol may help some of you reduce the high cost of Histame. The two in concert may have a better effect as well.

I'll be trying them all here soon.

6fdc6043699a77d35f110415ff4c5634
1
10 · October 12, 2012 at 10:47 PM

I'd like to add my pennyworth re Histame. I find it helps, but is not the total answer. I can't help feeling if it were cheaper and one could afford to take about 10 capsules a day it would be worth taking. I usually take two, four or even six capsules with an allergy tablet as well, that gives a better result than Histame alone. Not ideal I know, but when one is desperate......

59d367d77f4082717bade07508624db8
1
1198 · March 15, 2012 at 1:11 AM

I bought DAOsin (cheaper than Histame, $15/30 capsules on Amazon) last week more as a diagnostic tool to see if I even have histamine intolerance, which is silly I know, but histamine intolerance was near the end of a long list possible causes for my flushing and weird reactions to meals and I was a bit desparate, and none of he other usual supplements (Vit C, Qercetin, B6) seemed to help. I can't really tell if it's working. It's been just as fickle of an experiment as anything else. Sure, I haven't been that symptomatic since taking it, but I've been fine for weeks on end too before histamine intolerance was even in my vocabulary. In any case, I think you might want to investigate a serious gut healing protocol as it seems to be the only path out of a diet that's becoming more and more limited and frustrating.

People have different reaction to DOA, it DOES really help some people and they use it for emergencies or when they travel. Others who are really sensitive react to the fillers in the supplement. Have you considered seeing Dirk Budka? He's an MD who runs a clinic in London that deals with histamine intolerance and other gut/intolerance issues. People with HIT seriously fly across the Atlantic to see this guy. As a side note, he is making a new supplement called HistRelief that is more powerful and contains no fillers. I believe it's coming out in May.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 4:01 PM

DAOSin is cheaper than Histame but it looks as though the tablets have more fillers so I'll probably go with the Histame. Incidentally, I've just found this, not very scientific anecdotal study on DAOSin done by Allergy UK and the manufacturer. Looks like it helps with some symptoms more than others. I've found mixed reports about Budka on the web and I don't think I can afford to visit him anyway. Looks like I'm going to have to take the plunge and go for the GAPS diet.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 4:04 PM

DAOSin is cheaper than Histame but it looks as though the tablets have more fillers so I'll probably go with the Histame. Incidentally, I've just found this, not very scientific anecdotal study on DAOSin done by Allergy UK and the manufacturer (http://forum.allergyuk.org/viewtopic.php?f=11&t=1568&p=6533&hilit=DAOSin#p6533). Looks like it helps with some symptoms more than others. I've found mixed reports about Budka on the web and I don't think I can afford to visit him anyway. Looks like I'm going to have to take the plunge and go for the GAPS diet.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 4:03 PM

DAOSin is cheaper than Histame but it looks as though the tablets have more fillers so I'll probably go with the Histame. Incidentally, I've just found this, not very scientific on DAOSin done by Allergy UK and the manufacturer. Looks like it helps with some symptoms more than others. I've found mixed reports about Budka on the web and I don't think I can afford to visit him anyway. Looks like I'm going to have to take the plunge and go for the GAPS diet.

3499 · March 15, 2012 at 12:29 AM

I can't find any sources for this via Google, but I wonder if it's possible for the immune system to develop antibodies to DAO... I guess it's possible that you have histamine intolerance because your body can't produce DAO without it being attacked by your immune system, but I can't back that up with any science.

E246df7366ba4b48f75b53378ed33282
424 · March 15, 2012 at 4:13 PM

I suppose it's theoretically possible to produce antibodies to an enzyme (they are proteins after all) although I've no idea how likely this is in practice. I think trying to heal the gut and correct any imbalances in intestinal flora is probably the best practical way to deal with intolerances.

C56baa1b4f39839c018180bf63226f7d
3499 · March 15, 2012 at 5:53 PM

Agreed with that. TJ's proposal is the way to go regardless of the cause.

7636e1e02ef91a46f20a42e07b565a4b
367 · March 16, 2012 at 6:25 PM

Could explain my terrible reaction to Histame? Interesting. Or it's the fillers, as StreakofLean mentions, or, who knows.

54065d11ced1510973bde69f6ed50882
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0 · September 21, 2014 at 11:01 PM

Hi TJ,

From the symptoms you describe, it sounds as if you have a pretty serious case of Histamine Intolerance (HIT). As you already know, this under-recognised disease occurs when the body is deficient in DAO enzymes, the agents that break down histamine. With excessive histamine circulating through the bloodstream to every part of the body, symptoms can manifest in a wide variety of ways including digestive disorders, headaches, sleep disorders, anxiety, heartburn, depression, hives and other skin problems - the list goes on.

There are several ways to combat HIT including -

* Following a striclty low histamine diet for 4 - 6 weeks, after which you may gradually re-introduce
the foods you normally eat

* Taking certain vitamin, mineral and other supplements to boost the effectiveness of the diet

* Healing the gut where DAO is produced, to increase your own natural DAO production

* Taking daily doses of DAO in a natural (and inexpensive) form by juicing young pea sprouts that have been grown in the dark

* Taking commercial products such as DAOsin and Histame

There is a wealth of further information on the topic at the website low-histamine dot com (Paleohacks wont let me add a link until I have 30 points!)
The book "Is Food Making You Sick?" includes much more information plus low histamine/amine/salicylate recipes.

Stress can be one of the many underlying causes of HIT, so take it easy and I wish you good health!

Sue

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0 · August 25, 2013 at 6:19 PM

TJ...I don't know if you've solved your problem yet or not but I've recently been reading about EPD or LDA as its called in the States now. I hope to begin this therapy soon. My husband is a family doctor and he believes it will help me even though it is considered "alternative". It was discovered and used in the 60s by a doctor in your country! Read up on it...it might just solve your allergy problems, which is what it sounds like you have.

72cd359efb959175e2c7786ea0450879
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68 · August 23, 2013 at 8:55 PM

I just began taking HISTAME @ 1 cap w/ each meal. Am getting loose stools and gas. When I stop, it sibsides. Anyone else getting this???

F511c3698564c518ec440d105120eb77
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0 · August 15, 2013 at 12:39 AM

Hey...I am 26, a girl, and have similar problems and am wondering what will be left of me as well...it's definitely difficult...I tested negative for thyroid dysfunction in my blood, but my gland is enlarged, and my nephrologist explained that this means it is overcompensating and overtaxed (seems fairly obvious...though my endocrinologist was indifferent about it). I recently started taking just 2 drops of iodine a day - which has helped me stop feeling what I thought were diabetic symptoms where I would just get extremely lightheaded and unable to form sentences properly...also I have almost no bloating now which is pretty incredible for me...iodine is a very helpful medicine but also really powerful and a little goes a long way....though I am still having an awful time with diarrhea and am wondering about histamine reactions...I think variety as much as possible is important, but I am wondering as well what to do. Qigong and deep breathing are really really helpful...and I feel I am slowly getting better...also enzymedica digestive enzymes are really really good. I have only just read that probiotics can be very aggravating to people with high levels of histamines, and I eat a lot of fermented food like yoghurts and homemade sauerkrauts, so I'm hoping that cutting this out will really help. May be something to look into...also I thought that I couldn't eat grain until I realized it was to do with my iodine deficiency, and now i don't have bloating - though quinoa and brown rice are both high histamine foods so I'm working on having a lot less of them. Maybe see a dietitian or naturopath...I am looking into this now myself as it has become a little insane - and it can make you pretty isolated. Hope you feel better.

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0 · July 19, 2013 at 11:26 PM
Bd5950cefcfc70b742aaab72032f865b
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0 · July 19, 2013 at 11:25 PM

Check this web, it was really helpfull for me

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0 · July 17, 2013 at 11:25 AM

Hi everyone, I too suffer with Histamine Intolerance. I have taken Daosin (2 tabs with main meal each day) for months now and I find that it does help some days, but not every day. However, I must say that the main thing that I have learnt is that I have to drink plenty of water every day. Lack of water in the body is said to cause the body to make extra histamine and in my case that is true. Also, I take antihistamines (Fexofenadine 180mg twice a day, (just started taking 3 a day in this hot weather). These help me more than anything else. For anyone out there that has the constant migraines, Migraleve Pink is very good. I also take AVAMYS nasal spray, and that works too. I was under the Brompton Hospital as my allergies and high histamine levels were making me so ill and they prescribed the Fexofenadine, Avamys spray and Daosin. Plenty of water, no spices (I live on spicy food!) only fresh meat and no tinned food or foods that have been matured like cheese. Its hard to find something that you can eat without having a reaction. Some days when I feel really ill all I eat is special K with milk. Anybody got any other tips for me?

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0 · July 11, 2013 at 4:58 AM

These videos will help explain your food problems and give you more information about histamine intolerance:

http://m.youtube.com/watch?feature=plcp&v=H3iKY2FkChQ

http://m.youtube.com/watch?feature=plcp&v=cneLSubFEA8

http://m.youtube.com/watch?v=RGITUF26hr4&feature=plcp

I personally have had good success with Histame and DAOsin. I also use Allerase between meals and Similase with meals.

DAO is made in your gut. If your mucosal lining is compromised at all (whose isn't these days?!) then your DAO production can be compromised, therefore leading to an excess of histamine circulating in the body. It's more complicated than that, and yes, SNPs and the methylation cycle is involved too. The videos are easy to understand and should at least help those wanting to learn more.

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0 · June 16, 2013 at 2:57 PM

the daosin product has helped along with limmiting my histamine intake. gingergirl i know just how you feel the next day! i wake up tired and sore takes me a while to get moving!

i feel better if i skip or eat very little in the morning, a light lunch and then a good size meal at night but not too late!

8e2e950ac49a21b1a0e8ee74156db4ea
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0 · April 20, 2013 at 3:50 PM

Hi, I'm not sure who else has had success, but I know Taylor answered. After years of unexplainable symptoms and the belief I had an anxiety problem or even asthma, I've joined the ranks. Yes, a gut problem is part of this and makes reactions more severe, but I definitely have a histamine intolerance. Most food intolerances seem to go hand in hand with candida when your system is too run down. Last night, I used the supplement and was able to have a large meal with sour cream, sugar and RED WINE no problem! No sleepiness, stomach pain, sore throat, eye pain, tingling or tightening muscles! But...does anyone know about next day effects? Like pizza and wheat and sugar can make me very sore and groggy next day (probably feeding candida), wine usually had me waking up sore throat and congested. Does the supplement help with lingering effects or only within the first hour or so. I think it willbe a godsend for certain foods, but isn't a answer if you need to pop them like candy or they don't tackle the fatigue, sluggish, soreness, congestion issues. I would like to hear from somebody who has trialled it longer than me! :)

765cc12b1e65b8c4a594008f22e047ad
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0 · March 06, 2013 at 9:23 AM

Hi all. I have been considering taking some kind of diamine oxidase supplement but it seems like they all have a bunch of fillers in them, I was wondering if anyone has found a brand that doesn't have all of these fillers?

Fc1048186159ea5146222c16e8497305
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0 · February 18, 2013 at 7:56 PM

my main problem is with mold! the lower the mold count the better i feel. and have less food,skin problems. last summer was hot and dry best i have felt in 10 years. also found were the mold was hiding in my basement.

i have a history of living in moldy homes. i wonder how many people with these problems live in damp humid places?

mold,yeast and fungus are all in the same family and are very adaptable. so rotating foods and anti-fungles seem to work the best for me. i have also had some luck with DGL but only for a few days at a time it locks my muscles up.

too much histamine does make sence.

055229093e7ce8726eba6d8e19865594
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10 · February 17, 2013 at 3:33 AM

I've found xylitol to help with the anti-fungal part. 1/4 tsp twice a day. Though more (up to 50 grams a day) is fine.

47f28e336f2fdd9ea348576688b206ec
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0 · February 10, 2013 at 12:33 PM

Hi all with the histamine problems.....I haven't tried the supplement yet but plan to do so. Many of your symptoms sound like Mastocytosis which can be in the skin with many/various itchy rashes called Subcutaneous Mastocytosis or it can affect the organs which is more serious. I have the skin problem which can be hell but now I am seeing a specialist in Toronto who knows about this condition. The bad news is it is very rare and not all docs are aware of it. Just google it. There is a wealth of information at www.mastocytosis.ca photos can be seen at www.flickr.com/photos/mastocanada.

There are tests to determine the severity....Serum Tryptase blood test along with others is key. You can still have it even if this test is in normal ranges. Proper skin biopsy could do the trick also but you have to know the technique.

I see a specialist dermatologist....He has prescribed H1 and H2 blockers to keep it under control...and it helps...150 mg ranitidine twice daily with 10 mg of Reactine per day. In USA there is another antihistamine...forgot the name which is the same product....your pharmacist will know. But better to see a specialist for proper diagnosis. Most important stay away from aspirin and all pain killers with aspirin/salycilates and minimise foods/supplements/herbals/medicines high in salycilates. Remember..not everyone will have this condition but it is important to get checked with your doctor for proper treatment. Good Luck.

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30 · January 08, 2013 at 12:59 AM

I'm in Canada, and recently found this site to offer the most reasonably priced DAO supplement: https://www.swansonvitamins.com/swanson-ultra-daosin-300-mcg-30-caps They also shipped without charging both an arm and a leg, and the package arrived quickly.

My histamine intolerance re-appeared after going paleo almost two years ago. Although a low histamine diet should be the first defence, I do find the supplement helps for those occasions when eating out, or over the holidays.

C40c63d8056afcda66f273f45ecb7570
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0 · December 28, 2012 at 9:10 AM

Hi

My wife and I both suffer digestion problems - IBS etc.

I also had bacterial dysbiosis.. In UK you can get it tested for in London at BioLab. The consultant who referred me is Professor Brostoff.

Anyway even after test he recommended a new antibiotic which wasn't released in UK and had to use Metronidazole instead. It works for a month or so and is nasty stuff.

My wife kicked off badly sometime ago and I asked my parents holidaying in India to buy some Rifaximin. Gave it to the wife and hey presto her symptoms of bloating, pain etc were 90% improved. Still that way 9 mths on.

It's an antibiotic worth trying because it works directly in the gut, very little is absorbed into the bloodstream.

I've tried DAO - don't just assume you are intolerant to Histamine or lack DAO. It could be another allergy and histamine in the diet is exacerbating the primary allergy symptoms. All DAO is doing is neutralising the dietary histamine to prevent the additional aggravation. I use it for that..if i have pizza, beer, wine etc.

I think I have a slight allergy to dairy, when I have high histamine foods it makes it much worse so DAO helps dampen the effect.

My tuppence worth if it helps anyone.

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0 · December 20, 2012 at 12:02 PM

I started taking DAO for my migraines. My assumption is that I have a histamine problem more than anything. I'm about 80% paleo but more like 60% around the holidays. I am still taking my regular migraine medication but still have seen a reduction in frequency of headaches since supplementing with DAO (daosin). I take it only when I eat terrible delicious food like ice cream/ GF pizza or when I'm out at a restaurant. I will definitely agree... it is in no way a complete solution and I won't ever take it everyday. Probably the best option is to moderate high histamine foods.

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0 · December 11, 2012 at 7:09 PM

I had some genetic testing done because I have a Mast Cell Disease (Systemic Mastocytosis) that gives me SEVERE "allergic" reactions to just about everything. But get this...I'm NOT ACTUALLY allergic to all this stuff. I've been tested for just about everything under the sun. I'm allergic to a couple of things but not many.

I've been living on a low histamine diet because my Immunologist and I noticed I was reacting to LOADS of high histamine containing foods. Now, one day I can eat spinach and be fine; and another day I eat spinach and I need an epi pen and medical intervention. What gives??

So, I've learned that on a SPECIFIC GENE, on a SPECIFIC allele you can tell whether you are one of those people who have this marker for low DAO (diamine oxidase) one of the enzymes responsible for degrading histamine. So I went to my test results and had a look...guess what? I am.

So is THIS why I REALLY having "allergic reactions" to foods??? And does it have NOTHING to do with my Mast Cells having a dumping party in my blood stream? Or is it both?

And what do I do about it?

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80 · November 27, 2012 at 6:55 AM

I also get flushing, sinus problems, headaches, heart racing, and occasionally itching after eating sometimes, and my doctor thought it could be histamine intolerance, so I started looking into it.

I tried Histame, mainly on the idea that it might mean something if it helped. It did make some difference, although it by no means fixed me. Maybe if I could afford to take half the bottle at a time, but I never tried that. Nonetheless, it seemed to help some.

I've discovered that taking betaine HCL often knocks out my symptoms pretty much completely. This may be completely idiosyncratic, but it seriously works. I don't know if the extra acid breaks down the histamine before it gets to my intestines, or if it kills off nasty bacteria or yeast or something in my small intestine, or something else, but it makes a huge and noticeable difference. I started taking it for acid reflux problems (which it also helped) but then I noticed that my increasingly-common flushing after many meals went away!

I took the HCL for awhile, ratcheting down my dose whenever it seemed to make my symptoms worse instead of better. I was off it for months before my problems, both the reflux and the flushing, etc., started to come back. Doing another round of HCL helped again. I've gone through a few cycles and it always seems to work, though never truly permanently. Something to consider!

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424 · November 27, 2012 at 12:59 PM

Thanks for sharing your experience Tess. Glad you've found some relief from using the betaine HCl - sounds like your problem could be linked to low stomach acid. I've tried the betaine HCl for months at a time but sadly it does nothing for me.

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10 · November 24, 2012 at 2:43 PM

Ya'll might want to look into mast cell activation disorder. It's a relatively new clinical entity so not well known yet, but involves overactive mast cells, which of course pump out histamine along with about 200 other chemical mediators. There's a lot of overlap of symptoms between that and histamine intolerance.

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0 · November 17, 2012 at 6:24 PM

I got a free sample of Histame about 6 months ago. What caught my eye was it said for food allergies so I requested the free sample. They absolutely work for me within a few minutes. Because they are so expensive I only take them if I have a major sneezing attack after eating. So far they haven't failed me. As a side note, years ago I went through a series of shots at the doctor’s office because I got terrible migraine headaches which were finally diagnosed as "histamine" migraines. I wish I could figure out why my body over reacts to histamine. But whatever the case the Histame pills work great for me.

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0 · October 21, 2012 at 7:28 PM

hi, having the same problems & some one told me that it might be this! so my question to you all is has anyone tried echinacea! it's suppose to be a natural anti-histamine.. the only problem is you can only take it for 8 weeks then you have to have a 2 week break but it's a lot cheaper than the tabs your getting! im gonna have a try..

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424 · September 07, 2013 at 1:28 AM

Did this work? I've not heard of echinacea being used as an antihistamine before. I've taken it before for other problems but can't say I noticed it made a difference to my histamine symptoms.

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0 · October 16, 2012 at 1:47 AM

I have to ask this question. I just read about histamines in food tonight and I am wondering if this could be my issue also. I looked at buying Histame, but the price put me off. So I am wondering if anyone can answer this. Why can't I just take a nightly Bendryl? (They make me sleepy, but I am fine the next day.) Won't the antihistamine help offset the food histamines?

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424 · November 12, 2012 at 5:50 PM

Hi Carolyn. Antihistamines like Benedryl don't actually reduce the histamine load in the body. They just block certain histamine receptors in the body. They mask some of the symptoms but don't do anything to solve the underlying problem. They might help on a short-term basis if the symptoms are very bad but they'll do nothing for you in the long term. (In a way the DAO is a bit like this too but at least in theory, it's reducing the total amount of histamine in the body).

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0 · October 05, 2012 at 8:31 PM

TJ, any updates on the DAO?

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424 · October 06, 2012 at 2:01 PM

I've tried it several times but I honestly can't say whether it's working or not. I had a massive flare up of symptoms a few weeks back and I'm still all over the place. I'm not sure it's having much of an effect - it's certainly not a miracle cure anyway. I've started the taking the supplements mentioned by SunnyCo above and I think they're having more of an effect than the DAO, but it's too early to come to a firm conclusion.

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20 · October 03, 2012 at 6:53 PM

BTW, ayone who is interested in trying the DAO supplement check out Swanson's Vitamins they have their onw brand called DAOSin 30 caps for $39.95.

I have not tried DOA but have ordered MANY MANY times from Swansons. Highly reputable company.

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0 · October 01, 2012 at 4:09 PM

For yeast and persasitic overgrowth I would limit your carbs. which many of you are doing. Make sure the kefir you are drinking is low carb because if you look at he back it got like 24g of carbs in it. I would increase fermented foods such as kambucha and sourcrout. Increase Saturated and Monousaturated fats and take a full spectrum digestive enzyme before meals. A lot of these reaction can also be related to leaky gut syndrome.

Dr. Daniel Pozarnsky, DC http://www.balancechiropracticandrehab.com

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0 · August 19, 2012 at 9:21 AM

Just so you guys know. I tried histame yesterday and i used to fall to the ground in the bathroom after eating any dairy or eggs, couldnt have gluten either but it wasnt as bad. Let's just say today I ate a pizza a burger and chocolate and eggs for breakfast. It sucks that ppl aren't saying histame works but it is a god send for me. Give it a shot. I feel like i can live again, it was worth spending the money to experiment on it. I had lost almost all hope and this was my last go at it. Thank god I tried it.

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0 · July 25, 2012 at 2:42 PM

Hoping someone with direct experience will reply about DAO (I've already read the Amazon reviews), but to those who've tried, TY. I underwent experimental therapy with live organism helminths in 2010 for an unrelated issue, which improved; around that time I also went paleo, and added many high histamine foods to my diet. I got significantly worse, so under medical advice I eradicated the helminths. No change. I made a dietary connection recently, and I too think gut dysbiosis is at the heart of the issue. Unfortunate that the helminths didn't help the issue, but I may revisit the issue again with another species after I consult with my GI.

8b4d1ba636ee4ec909b1f17ea41d6be1
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0 · July 24, 2012 at 7:25 PM

Hello, can someone please follow up on use of DAO? Its very frustrating to find that someone is trying something, and then they don't report on their long-term experience. It sends a strong message that the substance/product is a waste of time, but it could also mean that the success was so profound that the person has gone on about their life and forgotten about reporting thier success. We in the trenches have no way to know the difference! Amine intolerance is something that has kept me from paleo. Please help me and others by checking back in about your experience. TY!

E246df7366ba4b48f75b53378ed33282
424 · July 25, 2012 at 11:34 AM

I don't know your personal circumstances but the DAO could give you some breathing space, if it works for you. The product reviews on Amazon/iHerb suggest that it helps some people but not others. Longer term, I'd recommend looking into a gut healing protocol. I'm afraid I can't give you much advice at the moment. I'm out of the trenches but still bogged down in no-man's land. All the best in addressing your amine intolerance. If you have any success please share too!

22fd82abf435768244f8d074430cd1e6
580 · July 25, 2012 at 12:36 PM

I am really wondering how you manage with the GAPS, given the fact that fermented foods are so high in histamine. Do you react to broth etc ?

E246df7366ba4b48f75b53378ed33282
424 · July 25, 2012 at 1:16 PM

I had problems initially, but I concentrated on the broths and fresh meats first (with very limited veggies) trying to make the diet as low in histamine as I could. I stuck mostly with fresh lamb and beef, avoiding pork and fish and only adding chicken occasionally. I also took l-glutmaine to supplement the broths, which luckily, I tolerated ok. At first I just had probiotic capsules (BioKult, then added a Saccharomyces Boulardii supplement). I didn't add the fermented foods in until later, and then starting with small amounts and gradually building up.

E246df7366ba4b48f75b53378ed33282
424 · July 25, 2012 at 11:26 AM

Hi wormgirl1. I didn't purchase the DAO in the end. I decided it was just a 'sticking plaster' that didn't properly address my digestive issues so I'm trying a GAPS-diet-type approach to sort out the gut dysbiosis which I believe is at the root of all this mess. I've posted a few updates on here but they're buried in the comments. I'll add a proper update onto the end of the question so it's easier for people to find.

E246df7366ba4b48f75b53378ed33282
424 · July 25, 2012 at 1:21 PM

I guess I'm lucky that my histamine problems aren't as severe as some people's. I think I have some sort of small bowel bacterial/yeast overgrowth, and keeping this in check with low carb/low FODMAP helps with the histamine problem. I still get issues if I eat too many histamine rich foods on consecutive days, but not as bad as before. I've also been taking vitamin C (as ascorbic acid) with potentially problematic meals and milk thistle extract. I can't say that one thing in particular has 'worked' but the combination of things is having some effect.

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