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Has anyone used diindolylmethane (DIM) for hormonal balance?

by (565)
Updated about 5 hours ago
Created January 25, 2011 at 1:25 AM

Heard about it recently and was wondering if it helps achieve hormonal balance as it alleges. It seems like it could be helpful considering all the xenoestrogens in our environment. Here's a link if you're curious: http://www.dimfaq.com/site/articles.htm

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17083 · December 19, 2013 at 4:27 PM

Right, it prevents aromatase from converting testosterone into estrodiol in men, and helps the liver get rid of estrodiol.

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0 · July 16, 2013 at 10:08 AM

Had a problem and had to post before I was finished. Anyway, the second and third months have been worse. The second month I got my period on day 37. Two weeks after that, I got my period again! I had insomnia for two weeks in a row, worse than ever before. I suspect it's the DIM. My doctor wants me to keep on taking it, saying that my hormones are "trying to figure it out," but the symptoms suggest to me that it's making me more estrogen-dominant than increasing my progesterone. Not everything works for everyone and certainly even medications don't work the same on everyone.

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77 · June 17, 2013 at 1:36 AM

It does not have the ability to lower estrogen...

96440612cf0fcf366bf5ad8f776fca84
17083 · May 17, 2013 at 5:09 PM

Never heard of this. Got any pointers to studies?

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0 · June 20, 2012 at 8:24 PM

(And I have been diagnosed with autoimmune low thyroid.)

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78407 · June 09, 2011 at 6:53 PM

Your other comment about removing exogenous endocrine disruptors from diet and lifestyle is spot on! I have been working on that for a few years now. I think I've gotten rid of 80-90% of the worst offenders.

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78407 · June 09, 2011 at 6:47 PM

I started taking it as a way to optimize my livers handling of Estrogen as I am estrogen dominant and getting hormones balanced is a breast health protocol.

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78407 · June 09, 2011 at 6:46 PM

Of course it's better to eat food. But the foods that do what DIM does are not so good for the thyroid. Also if you have fibroids, bleeding and high estrogen with a history of estrogen based breast cancer, I feel that intervention beyond food may be indicated. Do you think that women might need something different than you would as a man?

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39821 · January 25, 2011 at 6:44 PM

I just try to do the best I can to remove exogenous endocrine disruptors from my diet/lifestyle. If that means all organic and no BPAs, then so be it. I always go as far away from "magic pill syndrome" as possible, especially when it comes to hormones. There are far too many complex feedback loops that can go nuts if you try to override something.

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2065 · January 25, 2011 at 3:38 PM

I agree with both of you. Getting your diet right is the most important, but unfortunately it doesn't magically fix everything. Once hormonal balance goes awry it is a bitch to correct.

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565 · January 25, 2011 at 2:58 AM

That may work. I am beginning to think however that a few chronic conditions like acne that remains unaffected by diet may have something to do with all the excess estrogen we are exposed to in our lives. Pesticides can have an estrogenic effect as well as chemicals in plastic and water may also be contaminated with it from contraceptive waste not to mention phytoestrogens. It also seems that we may have historically eaten more testosterone from bull meat than we do nowadays (http://donmatesz.blogspot.com/2010/12/practically-primal-perspective-on.html) hence the question.

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C8521a858edd480815a55f683afff86a
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2065 · January 25, 2011 at 3:30 PM

Yes, I took DIM after I stopped birth control. I read that it can help bring hormonal balance faster. It was a mistake, I had a very strange reaction to it and couldn't take it for more than a few days. I felt like I had been drugged, really lightheaded and dizzy with extreme dry mouth and lips. A supplement should not do this, and it was definitely the DIM, no other factors were involved. The side affects would hit about 30 min after taking it and last awhile.

I don't think enough research has been done about this particular supplement and I think it's very problematic to isolate one compound in a plant and take only that. Nature works through synergy.

I understand your worries about xeno-estogens, but first there are things you can do to limit exposure. I don't ever drink from plastic containers and plastic wrap is banned in my house! I don't buy food that comes in plastic except my meat, which is unavoidable. If you can buy organic produce, you don't need to worry about synthetic pesticides. Unless you 're seeing real signs of hormonal imbalance, you shouldn't worry too much. A healthy body can process a lot of toxins.

Since we often can't help being exposed to toxins, the best way to help the body IMO is to support the liver and kidney. I take Burdock, Dandelion and Milk thistle tinctures. There are also herbs specifically for balancing hormones in men if you do a little research. I take Chaste Tree and Dong Quai which are classic hormone balancing herbs for women. Don't take herbs in pill form, they are usually garbage and waste of money. High quality extracts are the most potent. Good Luck!

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30 · October 03, 2012 at 1:46 PM

I used it, and it brought my menopausal hormone levels back into normal range, and all hot flashes are basically gone, I use it in conjuction with B vitamins. I also, don't eat sugar or hot spicy foods, it seems to trigger hot flashes, but not as bad, since I take the DIM. I love DIM!!!

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10 · December 05, 2012 at 6:21 PM

Per www.vrp.com, Vitamin Research Products: Individuals would have to consume prohibitively large quantities of raw cruciferous vegetables in order to achieve the known effects. Studies suggested that 1-2 pounds of these vegetables must be consumed in order to achieve this clinical effect.13 While consuming large amounts of fruits and vegetables is sound health advice, cruciferous vegetables in particular are difficult to digest for many people, especially 1-2 pounds??? worth. Furthermore, eating large quantities of cruciferous vegetables is known to be goitrogenic (enlarging the thyroid gland) and can lead to thyroid problems. Interestingly, while cruciferous vegetables have been found to be goitrogenic, DIM has actually been found to inhibit the growth of primary goiter cells by 70 percent compared to untreated controls. The same study found that DIM inhibited a number of different thyroid cancer cell lines.14

For individuals who want to confer protection against hormone dependent health conditions, supplementation with DIM is therefore preferable to eating large quantities of cruciferous vegetables.

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30 · October 10, 2012 at 11:44 PM

I took it, and am still taking it. It balanced my hormones out, took my hot flashes away, and cleared up the dark spots on my skin.

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10 · May 02, 2012 at 11:48 PM

I've had chronic adult acne for years now with no relief from changing diet, greens skin plus supplements, Accutane, no oil hair products. Finally I realised I'm very high in estrogen and low in progesterone (by having problems concieving-they measured my hormone levels). Estrogen is my problem. As soon as I started taking progesterone creme day 21-28 and taking primerose oil supplements to help balance hormones I achieved clear(er) skin. It's such a relief. I also realised I've been terribly deficient in Vit D. So now with primrose, vit D vit C and greens for skin. I hope now I've lessened my chances of cancer, with high estrogen, low vit D its a catastrophic combination. This supplement is vegetable based so unless you're allergic to veggies, I can't see it being adverse. I haven't tried it however I am willing to. We need to support more tests for natural remedies. Unfortunately the Conservatives in Canada and the Republicans in the USA have stifled research of natural remedies by allowing pharmaceutical companies to monopolise the health care industry, both parties have prohibited products on the market that don't have "pharmaceutical" labelling into the market.

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39821 · January 25, 2011 at 1:41 AM

I think I'd rather eat real food and balance out my hormones that way, thanks.

77877f762c40637911396daa19b53094
78407 · June 09, 2011 at 6:53 PM

Your other comment about removing exogenous endocrine disruptors from diet and lifestyle is spot on! I have been working on that for a few years now. I think I've gotten rid of 80-90% of the worst offenders.

77877f762c40637911396daa19b53094
78407 · June 09, 2011 at 6:46 PM

Of course it's better to eat food. But the foods that do what DIM does are not so good for the thyroid. Also if you have fibroids, bleeding and high estrogen with a history of estrogen based breast cancer, I feel that intervention beyond food may be indicated. Do you think that women might need something different than you would as a man?

Thumbnail avatar
39821 · January 25, 2011 at 6:44 PM

I just try to do the best I can to remove exogenous endocrine disruptors from my diet/lifestyle. If that means all organic and no BPAs, then so be it. I always go as far away from "magic pill syndrome" as possible, especially when it comes to hormones. There are far too many complex feedback loops that can go nuts if you try to override something.

C8521a858edd480815a55f683afff86a
2065 · January 25, 2011 at 3:38 PM

I agree with both of you. Getting your diet right is the most important, but unfortunately it doesn't magically fix everything. Once hormonal balance goes awry it is a bitch to correct.

D0578c3826123f66a80b034cd3e78816
565 · January 25, 2011 at 2:58 AM

That may work. I am beginning to think however that a few chronic conditions like acne that remains unaffected by diet may have something to do with all the excess estrogen we are exposed to in our lives. Pesticides can have an estrogenic effect as well as chemicals in plastic and water may also be contaminated with it from contraceptive waste not to mention phytoestrogens. It also seems that we may have historically eaten more testosterone from bull meat than we do nowadays (http://donmatesz.blogspot.com/2010/12/practically-primal-perspective-on.html) hence the question.

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0 · May 31, 2014 at 12:43 PM

Just thought I'd add to this discussion and say that I used to get the brain fog, dizziness and even headaches when I first started taking a DIM supplement (DIM Plus), but I have since learned that it is extremely important to be supporting your liver whilst taking it (at least while your body adjusts to it!) Remember, the DIM is making the body expel the bad oestrogen from the body - and the liver plays a huuuuuge part in that detoxing as it's one of the main oestrogen-processors in our body. Support your liver while you take a DIM supplement and you should be fine. A liver supporting supplement made the difference for me! No more side effects. And the DIM, I believe, is making a really noticeable difference to my skin, alongside a healthy diet of course! And another special secret for giving hormonal, cystic acne the kick: eat/drink omega 3 rich hemp seed oil! Use it on your face too. My skin loves it! Good luck!

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0 · September 04, 2013 at 3:33 PM

Honestly after reading all the posts I am confused. I had bio identical hormone pellets put in at the end of July and the Dim was recommended as a supplement to it. I have had terrible insomnia taking either Ambien or Ibuprofen pm to help me get 5-6 hours of sleep. The bigger issue is the constant pain I feel in my feet. I was starting to think Fibromyalgia or RA but decided to stop taking the Dim and a huge difference. Will play with it the next week or so and see if it starts again when I start the Dim.

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0 · August 13, 2013 at 4:19 AM

The best product for DIM is Estroblock. However, it is not in Canada. A decent one in Canada is called Estrosmart (50 mg a capsule) by Lorna Vanderhaeghe. It is a hormone balancing supplement and has other great ingredients as well.

Vanessa

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0 · July 18, 2013 at 3:55 AM

I am 34 and from Australia, I am Estrogen dominant by about 30 x the normal amount and just had 3 benign tumors removed from my ovaries. The doctors cannot figure out what is happening because my bloods do not match my symptoms. I have not had my period since January and have gained over 22 kilos. I researched DIM and ordered from America as it is not available in Australia, It arrived today and I have taken one capsule 4 hours ago and keep nodding off at my work desk - that may not be related, however from what I have read DIM is a powerful detox therefore when your body detoxes you tend to get horrible headaches etc for at least two weeks if your body is especially toxic or you consume too much sugar. I will see how this goes as at this point I will try anything. If anyone else knows ways to rid the body of estrogen - that would be great! (I have already gone organic everything and cut out soy and sugar)

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0 · July 16, 2013 at 10:05 AM

DIM Is supposed to be in estrogen-blocker. Per my new homeopathic doctor's suggestion, I have been taking it for two months now. She also treated me with glutathione infusions and herbs to detox my liver.

I mainly wanted to see if I could cure my insomnia. I've had hormonal issues since I was 18 and a little insomnia before my period (part of my PMS), but everything got worse several years ago when I went through a stressful divorce. I went on progesterone cream a few years ago which was a lifesaver – literally. With that, plus eating more protein, I went from a 2 in energy (I had to lay in bed most of the day) to about a 6. Then, I went on Ashwaghanda which seemed to help my thyroid and/or hormones.

The first month after starting the new treatments with the DIM, herbs, glutathione was great. My insomnia was reduced 50%. I Got really tired for the first time in 4 1/2 years.

422af97d4b2cc5d45277897c1da91dee
0 · July 16, 2013 at 10:08 AM

Had a problem and had to post before I was finished. Anyway, the second and third months have been worse. The second month I got my period on day 37. Two weeks after that, I got my period again! I had insomnia for two weeks in a row, worse than ever before. I suspect it's the DIM. My doctor wants me to keep on taking it, saying that my hormones are "trying to figure it out," but the symptoms suggest to me that it's making me more estrogen-dominant than increasing my progesterone. Not everything works for everyone and certainly even medications don't work the same on everyone.

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0 · July 14, 2013 at 3:49 AM

That's the thing about natural "meds". Not everything works for everybody. I like DIM. I'm on bio-ident HRT, but once or twice a yr I do a bottle of DIM to get rid of the xenoestrogens that are unavoidable. My husband takes it too. Black cohosh helps many women with menopause symptoms, but it gives me HORRIBLE migraines (Only time I've ever had them). But I don't around telling people it's no good just because it didn't work for me. Texas

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77 · June 17, 2013 at 1:44 AM

DIM really normalized my Cycle and PMS after pregnancy. My period returned at 1 year postpartum and instead of regulating, it got worse every month. I ended up with hormonal hair loss, acne, bloating. I had a painful 40 day cycle with feverish body aches and cramps. Instead of actual blood just black goo came out and my period lasted for up to 11 days. After only one month on DIM, milk thistle, burdock root and vitex, my period was close to normal. After 3 months I had a 28 day cycle, a pain free period and bled fresh red blood for only 3 days. My acne bettered too, although it did not clear up completely. Probiotics helped my skin get clearer though.

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0 · June 13, 2013 at 10:33 AM

I am on BioIdentical HRT and thought I would try DIM to see if I could get the most out of the HRT. Within a day I was irritable and started having a headaches. This is the only alteration in my daily intake so I Know this was it. I stopped after 3 days because it made me feel like I did before my hormones began balancing with BIHRT. I do not know if this can be a normal side effect reaction or just specific to me, havent been able to find much info about side effect. Needless to say, attributed the problem to DIM and stopped it. Started feeling better w/in a few days. Just my experience posted on here to help others know if this happens to them it could very well be the DIM for some unknown reason.

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0 · June 06, 2013 at 2:16 AM

Where can I buy this product in Canada? I am in Ontario and the only product I have heard about in stores is an over priced "Nature's Way" brand that only includes 12.5 mg of DIM per capsule and it costs like 21 bucks for less than a months worth. I have tried ordering stronger concentrations via the internet and so far:

youngagain.com- never shipped the product to me so I am guessing it got held up at the border or they just stole my money.

vitacost.com- they were fine taking the money off of my credit card, but they never even sent me an email to confirm my order so they pretty much just flat out stole my money.

Is there ANYWHERE that I can go to physically purchase high potency DIM (at least 50mg per capsule) at a relatively fair price. Please do not tell me to order anything online because I will assume you are a representative from the website. I have officially been screwed over by both of the companies so far so I have absolutely no patience or tolerance for any more online purchases.

ANY help would be appreciated as I really want to try this stuff.

Thank you. Brad

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0 · May 17, 2013 at 7:45 PM

Cee Cee, Maria, et al - how much DIM did you take a day? I've been taking 200 mg a day for about a week and have felt no effect. I believe in it though but don't want to overdose. So how much did you take and when? I have hypothyroidism and overstressed adrenals plus i'm menopausal, or post. I find the thyroid med that i take causes my body to heat up as does tyrosine. And i hated being overheated when i was cold all the time!

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0 · May 17, 2013 at 3:01 AM

I have Hashimoto's Thyroiditis and started taking DIM 4 weeks after my double masectomy for stage 1 invasive breast cancer. Within one week not only did I feel better but now, after 3 weeks of DIM, I feel fantastic. My body is warmer (I used to walk around freezing) and I notice I have more energy. I am highly sensitive to all medications so I am thrilled that I am responding so well to DIM. Other than a 2-second dizzy feeling the first night I took it I have had no side effects at all.

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0 · January 10, 2013 at 10:40 PM

I recently visited a neurologist for migraines who informed me about DIM in an effort to get me off of estradiol which I have been taking for over 20 years due to early menopause and a hysterectomy and might be a contributing factor to my headaches. Each time I have tried to get off the estradiol I have literally gone insane from the hot lashes (floods) during the day and the consistent night sweats (every 45 minutes) leading to sleep deprivation, mental confusion, and lack of concentration. Since there is a history of breast cancer in the family I have been searching for alternatives but was presented with very little before now. I plan on trying it since research shows you would have to eat "2 lbs" (not cups) of raw cruciferous vegetables every day in order to have the same effect. The other surprise is the actual benefits for men as they age. There has been studies showing how it can prevent prostate and colon cancers. Overall it sounds like a great anti-inflammatory.

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0 · October 07, 2012 at 6:51 AM

I tried ActivaMune which was put together by the original scientific discoverers of DIM at UC Berkeley and it was very helpful for me.

ActivaMune DIM Immune Support Formula

Another resource that I found to be helpful was the following website with a lot of published studies on DIM.

Diindolylmethane Information Resource Center - UC Berkeley

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0 · June 20, 2012 at 8:23 PM

Guys, the fact that DIM is extracted from cruciferous veggies makes me think it could have an effect on the thyroid. When I eat cruciferous veggies I get low energy and dry mouth and eyes.

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0 · June 20, 2012 at 8:24 PM

(And I have been diagnosed with autoimmune low thyroid.)

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0 · April 04, 2011 at 12:43 AM

I started it less than a month ago due to concerns about peri-meni-pause and the changes your body goes thru including the dreaded Meni-pot! (new fat on your stomach you NEVER had before) I found articles on a high grade - I won't mention it because I am not 'promoting' anything - I have lost the extra abdominal fat, honestly haven't felt better in long time.. was it the supplement? I don't know for sure.. I think this article is really interesting- I think like THIS and any supplement that isn't pharmaceutical grade and not adhering to the 'good manufacturing' guidelines is the question of quality. The first comment made could be someone that took a 5 dollar bottle of crap claiming to be the product with low to no levels of it in there.. http://www.natural-progesterone-advisory-network.com/the-cruciferous-choice-diindolylmethane-or-i3c/ Do your research and I would highly recommend you give it a try.

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1344 · January 25, 2011 at 1:39 PM

I have heard a lot about DIM. They sell it on iherb.com and it gets really good ratings by the users. It makes you wonder. It is suppose to ward off Breast Cancer.

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78407 · June 09, 2011 at 6:47 PM

I started taking it as a way to optimize my livers handling of Estrogen as I am estrogen dominant and getting hormones balanced is a breast health protocol.

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-2 · February 17, 2013 at 2:35 AM

Warning DIM is a neurotoxin. I also thought hey why not try this for balancing my hormones seems harmless Several reputable doctors are even recommending it. Well by the 3rd day I couldn't think straight like being in the fog it never happened too me before very frightening. Come to find out it is a toxin for your brain and when I got off of it my endo came back worse than before because I feel it did lower my estrogen while I was taking it.

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77 · June 17, 2013 at 1:36 AM

It does not have the ability to lower estrogen...

96440612cf0fcf366bf5ad8f776fca84
17083 · May 17, 2013 at 5:09 PM

Never heard of this. Got any pointers to studies?

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