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New research: Saturated Fats INCREASE intestinal permeability!

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Updated about 19 hours ago
Created March 05, 2014 at 3:08 AM

It turns out saturated fats from foods like Coconut oils and from animal foods might cause leaky gut.

A recent study published last year but rarely spoken of breaks current trends on leaky gut theories.

"High saturated fat diet increased gut permeability and inflammation."

-- Lam YY et al.

Mice fed the control diet reported better gut microbiota and reduced intestinal permeability than did the mice fed a diet high in saturated fat who also increased inflammation.

Source: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0034233

0ba891d22837788c4d5ccf3f33f60329
30 · March 07, 2014 at 7:33 PM

Umm they were actually mice, not rats. Looks like your opinion is invalid! Just kidding. But really, good point on the omega-6 thing.

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41562 · March 05, 2014 at 1:45 PM

Don't try to pick on their competing interests… Nobody goes into research with no preconceived notions. Almost all research is expected results. It just has data to support it. The data is here, there's no denying that. The significance is what you have to question.

8b9c2dcd3dfc929a0428d3d6dac4918e
60 · March 05, 2014 at 4:10 AM

I don't know if our guts would be that comparable. But wouldn't make more sense if fat is being used as a carrier for fat soluble compounds? Not that its an issue if your not eating anti-nutrients or poisons.

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5356 · March 05, 2014 at 3:45 AM

Joined today...first post..opened with one study done on mice to your "point" and then your second post, an argument....all your eggs in one basket much?

I'm just kidding...you seem completely legit.

Can you link me a study on mice and what happens if you give them belly rubs? I like belly rubs too and, I just want to make sure we have the same reactions since we're exactly the same animal.

F9c5f1937e7339fa28a6c112192686c5
0 · March 05, 2014 at 3:45 AM

Well *PUFAs include Omega-6, but yes on the other hand, leaner meats would be more in context.

2eb1b3e896624be5506029e3fec3e9e2
0 · March 05, 2014 at 3:39 AM

or just more lean meats and meats high in PUFAs and MUFAs

543a65b3004bf5a51974fbdd60d666bb
4468 · March 05, 2014 at 3:19 AM

"Mice fed the control diet reported..."

why am i getting the picture of a mouse with a clipboard in my head...

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41562 · March 05, 2014 at 3:12 AM

Because a diet high in saturated fat is normal for mice, right?

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5 Answers

A7c1857ce53fb11a9351d05718c7070d
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273 · March 07, 2014 at 6:48 PM

The high fat diet was 60% calories from fat, yet only 32% I think it said was from saturated fat. The control diet was only 10%, that means we are lacking a description of about 20% of the fat content in the high fat diet.

I will place my bet that this 20% if from some type of industrial seed/vegetable oil (since that is standard feed ingredients...I think) that is high in omega 6 and susceptible to oxidative damage. This is probably what caused the finding in the high fat group.

Oh yes, and one more thing. They are rats, not people :-)

Also, read the below article, about half way through I reference a rodent study in which the diet was a bit more well defined and they actually found a reduction in leaky gut markers, I know they were alcoholic rodents, but still :-)

http://paleohacks.com/questions/516324/new-research-saturated-fats-increase-intestinal-pe.html

0ba891d22837788c4d5ccf3f33f60329
30 · March 07, 2014 at 7:33 PM

Umm they were actually mice, not rats. Looks like your opinion is invalid! Just kidding. But really, good point on the omega-6 thing.

7160a3fb485cb0af573c0292fdb08144
0
15 · March 05, 2014 at 3:51 PM

Well, that study does it for me. I will NEVER give my mice saturated fats again.

96440612cf0fcf366bf5ad8f776fca84
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17567 · March 05, 2014 at 12:15 PM

A= "Evidence is now persuasive that the gut may play an important role in inducing adipose inflammation and metabolic disorders."

B="The cross-linkage between gut microbiota, metabolic dysfunction and the immune system is best illustrated in Toll-like receptor-5 knockout mice which develop spontaneous colitis, insulin resistance, hyperlipidemia and increased visceral fat deposition"

C="Taken together the case can be made, see [19], that obesogenic diets induce gut dysfunction, which may lead to the stimulation of contiguous fat by an adverse microbial load and subsequently results in visceral fat inflammation and systemic metabolic dysregulation."

D="JO and LHS are or have been employed by AstraZeneca." - I wonder if they have some fat loss drug to sell from this "research"

So, take a bunch of mice that are known to spontaneously develop the shits, have insulin resistance, and increased visceral fat, and then they feed them fat and assume that the fat causes their gut flora to go out of whack and blame the fat. No, it's not the wonky genes that were damaged in these mice that spontaneously develop colitis, obesity, and insulin resistance, it's their diet.

So, A+B->C? Or is it:

1. Collect Underpants

2. ???

3. Profit!

Riiight. See, there's a lovely bridge between Brooklyn and Manhattan, I can sell it to you cheap, and you could set up a toll booth.. just gimme your credit card number, maiden name, and social security and sign these papers here...

32f5749fa6cf7adbeb0b0b031ba82b46
41562 · March 05, 2014 at 1:45 PM

Don't try to pick on their competing interests… Nobody goes into research with no preconceived notions. Almost all research is expected results. It just has data to support it. The data is here, there's no denying that. The significance is what you have to question.

F9c5f1937e7339fa28a6c112192686c5
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0 · March 05, 2014 at 3:36 AM

Research shows that leaky gut, inflammation, and related disorders are caused not only by lectins or Omega-6 fats (for example in vegetable seed oils and grains) but also by Saturated Fats. When will Paleo break the dogma and think beyond old habits of eating so much meat? Inflammation is connected not only to leaky gut but also heart disease, cancer, and Alzheimer's. Perhaps a diet rich in fruits and vegetables, and away from meats, is the most appropriate given these discoveries.

2eb1b3e896624be5506029e3fec3e9e2
0 · March 05, 2014 at 3:39 AM

or just more lean meats and meats high in PUFAs and MUFAs

F9c5f1937e7339fa28a6c112192686c5
0 · March 05, 2014 at 3:45 AM

Well *PUFAs include Omega-6, but yes on the other hand, leaner meats would be more in context.

76026e8ef496039d5075440ff731aa0d
5356 · March 05, 2014 at 3:45 AM

Joined today...first post..opened with one study done on mice to your "point" and then your second post, an argument....all your eggs in one basket much?

I'm just kidding...you seem completely legit.

Can you link me a study on mice and what happens if you give them belly rubs? I like belly rubs too and, I just want to make sure we have the same reactions since we're exactly the same animal.

76026e8ef496039d5075440ff731aa0d
0
5356 · March 05, 2014 at 3:31 AM

Why are mice Always screwing things up for the rest of us! Think of what else they'd ruin if they had thumbs.

Back to eating vegetable oils...stupid mice and their theme parks built to ruin families...

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