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Alzheimer and Ketosis

by 5216 · January 17, 2011 at 11:16 AM

My grandad was just diagnosed with alzheimer. My mom is now on a frantic search to learn as much about the disease as possible. I've heard a good about of noise about ketosis helping alzheimer's but haven't found too much of substance. Does a ketogenic diet help relieve alzheimer's symptoms?

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1118 · December 15, 2010 at 9:49 PM

I've recently become addicted (pun intended) to reading the Evolutionary Psychiatry blog by Dr. Emily Deans. The link provided breaks down her post archive by condition, so just scroll down to the 'Dementia' section and you can find all the posts on Alzheimer's.

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4531 · December 15, 2010 at 8:46 PM

Dig into this blog, Dr Newport has some good info on ketosis and Alzheimer's:

http://coconutketones.blogspot.com/

http://coconutketones.blogspot.com/2009_05_01_archive.html to get you hooked on the idea.

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3962 · January 17, 2011 at 11:16 AM

Yes, this study might be of interest.

http://www.nutritionandmetabolism.com/content/2/1/28

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did not examine high fat diets in combination with reduced carbohydrate intake. Here we tested the effect of a high saturated fat/low carbohydrate diet on a transgenic mouse model of AD.

Conclusion: Previous studies have suggested that diets rich in cholesterol and saturated fats increased the deposition of Aβ and the risk of developing AD. Here we demonstrate that a diet rich in saturated fats and low in carbohydrates can actually reduce levels of Aβ. Therefore, dietary strategies aimed at reducing Aβ levels should take into account interactions of dietary components and the metabolic outcomes, in particular, levels of carbohydrates, total calories, and presence of ketone bodies should be considered.


This article at the "Pediatric Journal" is an overview of current uses for ketogenic diets. It contains reference links to many studies, including the one above.

http://pediatrics.aappublications.org/cgi/content/full/119/3/535


I, too, recommend reading Dr. Mary Newport's blog:

http://coconutketones.blogspot.com/

All the best to you.

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10 · December 16, 2010 at 6:14 PM

A person with alzheimers is experiencing insulin resistance in the brain. This starves the brain of fuel and so you need to get a different fuel to the brain. A ketogenic diet will do this.

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4337 · December 16, 2010 at 2:03 AM

  1. There was a lot of buzz about coconut oil and MCTs on the theory that brain cells in the AD brain lose the ability to uptake glucose (so-called 3rd form of diabetes), so having some ketones floating around allows them to eat... A full ketosis diet is hard to do and may not be warranted (the beauty of MCTs). I haven't heard any updates in the past year or two though... Hopefully, that's not a sign that the method isn't sound.

  2. Similar story for methylene blue (blue acquarium die)... A UK company was trying to lauch a drug called Rember that was basicaly just methylene blue. There was a lot of buzz a while back and then nothing... You can buy mehtylene blue in a pet store and, if you are smart and careful, figure out how to titrate it to the proper dose... I don't know anything about side effects or safety issues so you should definitely do your research before trying something like this.

  3. I've also heard good things about high dose B vitamins... Claims that it can stop progression in its tracks.

The basic anti-inflammatories like vit D, fish oil (or better yet, actual fish; like wild salmon), turmeric, etc may also help slow progression a bit.

Go to the imminst forums for more and much better info that you will find here.

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10 · December 15, 2010 at 9:30 PM

Also, check out Phosphatidlyserine.

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858 · December 15, 2010 at 9:03 PM

I heard daily doses of coconut oil (extra virgin, of course) helps. I have no links to back that up, but I bet there are some out there.

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