Leptin

Leptin

Leptin Questions

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by 0 · about 1 hour ago

I began my paleo diet and bio hacking adventure about 18 months ago, but feel I have hit a brick wall and need some help to better understand my labs and situation. I???m hoping that someone might be able give me some deeper insights on reactive... (more)

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by 10 · about 2 hours ago

Hi I'm 19 obese male, 230 pounds. I just have a few questions I would like answered based on your own experience and knowledge. 1.) Is it better for me to buy mainly grass fed tallow or cold pressed coconut oil? I am on a budget now and so I... (more)

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NewPaleon 0 · July 20, 2013 at 4:23 PM

When I started Paleo a year ago, I had awful cravings for cookies, chips, etc. Then I read the Perfect Health Diet and started eating 1/2 - 1 cup of white rice with lunch and dinner and my cravings are mostly gone. I also do IF most days.... (more)

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by 112 · about 2 hours ago

The thing I do not understand is what the body does in relation to excess fat intake, if we assume a low-carb diet. Apparently acylation stimulating protein is created in response to chylomicrons which exist after eating fat, and can thus cause... (more)

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Anon_9 0 · April 08, 2013 at 11:17 PM

I don't know about you, but sometimes excess fat passes right through me, if you know what I mean. One of the consideration with eating that most people forget is that not everything you eat gets burned or stored. Sometimes it's broken down and... (more)

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by 100 · about 2 hours ago

Made the mistake of going too low carb and stubbornly sticking with it for a year despite rapid weight gain. Just realized that my symptoms (lack of energy, cold extremities and puffy face) was from a sluggish thyroid. Even have slight darkening... (more)

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Lumifer_1 0 · April 30, 2013 at 2:35 PM

Um, go to a doctor and ask for a thyroid panel blood test. Make sure it includes free T3 beside TSH and the other usual stuff. If you think you have serious problems with your thyroid, get the hard data, don't rely on "it seems my symptoms could... (more)

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by 638 · about 2 hours ago

Ok so I have always been a morning exerciser.. It leaves me feeling pretty good the whole day, plus the gym is about 90% less packed in the morning and its easy to find a park... and lets be honest, I am much more likely to exercise if I can do at... (more)

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James_3 0 · March 16, 2013 at 10:59 PM

My recollection on the Leptin Reset Protocol is that is for people that are Leptin resistant. If you aren't Leptin resistant, it doesn't apply to you. ie. exercise when you want. If you're Leptin resistant, he doesn't want you exercising... (more)

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by 55 · about 2 hours ago

Dear Paleo Hacks, I have been eating strict paleo for about 2 years. I found paleo after battling severe IBS with constipation. I have since transitioned into the full GAPS diet and am intent on doing GAPS intro this coming winter. My current... (more)

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Mimi_1 0 · November 29, 2012 at 6:26 AM

"Some kind of protein"? Elaborate , please. Change your 85/15 beef to 80/20, if you're eating lean meats, switch to fattier cuts of meat. If I ever have to cook lean meat, I always cook it with lots of heavy cream or coconut milk, or I make sure... (more)

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by 1187 · about 2 hours ago

Short question: Have you done carb nite and did it work for you? Long Question: Am I doing this wrong? Why isn't it working? My info below. About me: 5'2, 150.4 lbs. 38 years old female. Metabolically disordered much of my life. I've lost 20... (more)

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nthmost 0 · September 14, 2012 at 11:23 PM

I've worked with a couple of women like you who've done heavy keto and then switched to Carb Nite and didn't see results. Doing long term keto really fraks with your thyroid and leptin levels and it takes time to get them back where they should... (more)

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by 671 · about 2 hours ago

What's the data on the effects of a 20-24 fast after a refeed? Does the fast negate the leptin boost that the refeed is designed to provide? Will your body draw on those now refilled glycogen stores directly afterward, or does it continue to use... (more)

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igel 0 · August 20, 2012 at 8:10 AM

not exactly on the topic of glycogen/fat utilization after a 'feast', but this post may perhaps be of some service: "The 14-percent advantage of eating little and then a lot: Is it real?" (more)

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by 90 · about 2 hours ago

"Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity " Here's an interesting study - forget about the Glycemic Index, as... (more)

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Beth_WeightMaven 0 · July 16, 2012 at 12:23 PM

This is not a study, it's a hypothesis. The full text is available as a PDF download and I think it's well worth a read. Here's the author's conclusion: The increased storage life and convenience of some of our oldest agricultural products... (more)

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by 6229 · about 2 hours ago

Just curious if anyone has had this response to xylitol. Has your sense of sweetness been desensitized by continuing to use sweeteners? When you pull xylitol out do you notice almost everything including veggies like tomatoes and cabbages tastes... (more)

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SUSTAINEDfitness 0 · July 13, 2012 at 3:50 AM

The only sweetener I use is a little xylitol, and to me everything has tasted sweeter anyway since going primal/paleo. I feel that what desensitized people to sweets is the constant sugary drinks most people have. Since giving up soda, even the... (more)

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by 161 · about 2 hours ago

I saw the other similar topics, but while they provide some solutions, i didn't see many explanations in them. I have been paleo for two months and already lost one sixth of my weight. I have also been doing Leptin Reset for around three... (more)

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Don_1 0 · June 22, 2012 at 1:49 AM

You're putting too much faith in labels such as "leptin reset" and "adrenal fatigue". We are very complex and adaptable. Changes in your diet may be helpful, but the concepts you discuss are, at best, vastly simplistic. Either up your carbs, or... (more)

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by 235 · about 2 hours ago

Why is it that the only time I wake up hungry is when I have a big, late night meal? I rarely do that any more since starting paleo so I usually don't eat until hunger kicks in about 11 or 12ish. I thought I was leptin sensitive, as sleep, body... (more)

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August 0 · June 21, 2012 at 3:21 PM

I think you are normal. The modern obsession with breakfast isn't normal, and is largely a phenomenon brought about by the cereal industry. A ridiculous amount of money is spent selling breakfast foods and making it breakfast sound like a... (more)

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by 6229 · about 2 hours ago

Dr. Rosedale wrote a lot on MDA on telomere issues. I thinks he gives a pretty convincing argument that we need to wait for more accuracy, precision, and research before really using this in everyday practice. An snippet of a very long and... (more)

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gydle 0 · June 20, 2012 at 5:33 AM

I was intrigued by your post, thinking "well, you'd have to do some pretty gnarly genetic engineering to lengthen peoples' telomeres" and came across this quote by Stanford researchers in an article in PNAS: "In order for a cell to become... (more)

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by 1670 · about 2 hours ago

I am 5'2" and 110 lbs. My eating this past week has been ravenous and resulted in some binges and I think it may have been because of restrictions in nuts, fruit, and starches. But, I am also wondering if my leptin is messed up again or my brain... (more)

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foreveryoung 0 · April 09, 2012 at 1:48 AM

Because you have a high future discount rate.

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by 6418 · about 2 hours ago

Read it and consider: http://jackkruse.com/the-holy-trinity-ct-4/ Are you open to trying The Quilt's life plan? "A VLCer will always look average, but will a decent lifespans but they will never see optimal either. What is the name of my... (more)

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none 0 · February 28, 2012 at 1:54 AM

Drinks malbec from a box, sits in a tub full of ice, loads up on Tim Ferris and catches up on Robin Sharma tweets, stands back in amazment at the truth that unfolds!!! Shall I genuflect? Cross myself? Anoint myself in the waters of Lake... (more)

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by 15003 · about 2 hours ago

I am a real fan of Stephan Guyenet and Chris Kresser, but try as I might, I am struggling with the idea that a low-reward diet "reduces the fat set point." Now, I have no problems with the idea that a low-reward diet results in weight loss. And... (more)

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J__Stanton___gnolls_org 0 · February 13, 2012 at 10:15 AM

A "set point" is just a homeostasis we don't understand yet. For instance, there's no such thing as a "fat thermostat" in our bodies that we could turn up or down if we could just find the dial. There are trillions of cells in a human body - each... (more)

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by 161 · about 2 hours ago

I have been paleo now for 22 days. Have lost about 4kgs. I have been hearing a lot about this leptin reset. Tried looking up google, but everyone has a different explanation about it. Can anyone please explain it to me in simple terms. What... (more)

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Eric_12 0 · February 12, 2012 at 6:39 AM

Here it is: Dr Kruse says it best and this is a one page description: http://jackkruse.com/my-leptin-prescription/ It is very effective if you are leptin resistant.... (more)

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by 20 · about 2 hours ago

I weigh 190, lost 40 pounds before LR and need to lose 50 more. I have been doing the Leptin reset for 3 weeks faithfully. I am very happy with it except I feel cold all the time, even under lots of blankets at night. Am also taking fish oil, PQQ,... (more)

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James_3 0 · February 05, 2012 at 9:17 PM

You checked your calories? If you're feeling cold, could be your body's not feeling that it's getting enough.

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by 5 · about 2 hours ago

I started paleo about 2 months ago and was on it strictly for 1 month. I lost 12lbs (I'm 5'1 and 137lbs) and felt great. I went on vacation, didn't follow paleo for a month, came back and found myself .5lb lighter (same body fat %). The problem... (more)

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j3wcy 0 · February 05, 2012 at 3:45 PM

I would think about Jack Kruse's Leptin Reset Protocol http://jackkruse.com/my-leptin-prescription/ Lots of posts here and on MDA about people's success with this. (more)

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by 144 · about 2 hours ago

Anyone have thoughts about Dr. Rosedale's recent appearance on Jimmy Moore's podcast? He essentially distinguishes his leptin reset plan from Dr. Kruse's by recommending a much lower amount of protein, saying that the amount of protein... (more)

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August 0 · January 25, 2012 at 9:45 PM

Rosedale's thing on protein is that he doesn't want to trigger growth. This is based on research on the MTOR pathway. Protein over 20g at a meal supposedly triggers this pathway, as does carbohydrates. The researchers made a worms live longer... (more)

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by 1579 · about 2 hours ago

Hello. I am having some success restoring weight lost due to an eating disorder and am getting close to no longer being underweight. I am wondering if a leptin reset would be a good idea, to fix my metabolism which I assume is still not... (more)

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Mallory_1 0 · January 22, 2012 at 2:02 AM

get weight restored, see your doctor helping your recovery and get tests, then decide what you need to do. weight restoration is not a number, it is a place, mental and physical that your blood work can reflect. if it isnt up to par, hormones are... (more)

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by 45 · about 2 hours ago

According to much of the advice I've read surrounding leptin, the leangains approach is not very healthy. Skipping breakfast, eating at night, etc. I've tried each of them and leangains works much better for me. I'm just not very hungry in the... (more)

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Jeff__1 0 · January 19, 2012 at 11:45 PM

The leptin 'rules' are meant to reset sensitivity, as mentioned above. As someone who is leptin sensitive, I still follow the 'rules' for the most part and it really works well. I also include some IF as well as fasted workouts however. Eating... (more)

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by 15226 · about 2 hours ago

What is leptin's relationship to PEPCK? Does it stimulate or suppress it? Would love to hear thoughts on this from the sciencey types on here. edit: I think it's probably got to increase PEPCK... the second study measured a short term leptin... (more)

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akman 0 · July 03, 2012 at 9:12 PM

The Quilt is so far ahead of his time it's not funny. His year old posts are just starting to make sense. From today at http://medicalxpress.com/news/2012-07-discovery-cellular-pathways-converge-food.html : Now, researchers at Beth Israel... (more)

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by 2861 · about 2 hours ago

Do carbs ???spike??? leptin? This seems to be a central tenet to Dr. Rosedale???s science, but it appears to be false according to Carbsane. Is there any more evidence either way that anybody wants to share? (more)

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Lucas_Tafur 0 · November 29, 2011 at 3:27 PM

Yes, carbs raise leptin, but not in a "spiky" fashion. Edited to answer Evelyn: I think it is important to differentiate postprandial effects from chronic effects, ie. which show alteration of its pulsatile/circadian secretion. For... (more)

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by 691 · about 2 hours ago

How to increase your growth hormone naturally? Our Paleo ancestor didn't have the use of isolated amino acids, BCAAs or melatonin to pulse his growth hormone. Most of the proven techniques today to release growth hormone naturally where done by... (more)

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Dorado_Galore 0 · November 21, 2011 at 10:12 PM

Exercise: Lift weights. Do exercises that simultaneously work a lot of major muscle groups. Sprint (on foot or bike, or in pool). Diet: Growth hormone levels increase markedly when insulin levels are low. Chiefly carbs are responsible for... (more)

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