Leptin Resistance

Leptin Resistance

Leptin Resistance Questions

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by 0 · about 16 hours ago

I began my paleo diet and bio hacking adventure about 18 months ago, but feel I have hit a brick wall and need some help to better understand my labs and situation. I???m hoping that someone might be able give me some deeper insights on reactive... (more)

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by 2422 · about 17 hours ago

Is Stephan Guyenet correct in this regard? (Refer to: http://wholehealthsource.blogspot.com/2012/11/why-do-we-eat-neurobiological.html) Something I've noticed over the years is that when you make an animal gain fat by giving it a fattening... (more)

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Britt_2 0 · November 22, 2012 at 2:06 AM

I have observed that I can lose all of the weight I want while eating healthy. I did observe something kind of similar to this in college... but over a longer time period. I would gain 15 pounds, diet and lose 5-10 pounds, eat a lot again. I got... (more)

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by 2565 · about 17 hours ago

I've heard a lot of talk about how important balancing our neurotransmitters is, and the ones that are mentioned are usually gaba, serotonin, acetylcholine, etc. But I hardly ever hear about dopamine. Recently I've been doing some research on it... (more)

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interrobung 0 · May 04, 2012 at 6:18 AM

Your last paragraph sums up much of the belief of the human biochemically-savvy paleo populace, as I understand it, with some qualifiers. It is certainly the case that the leptin resistance we associate with obesity could have a role in decreased... (more)

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by 5768 · about 17 hours ago

On one of the Paleo Solution podcasts Mat LaLonde revealed that he does a protein fast in the mornings. Rather than fasting all together he has a can of coconut milk upon waking. He says that if you eat a little fat but refrain from eating protein... (more)

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Jeff__1 0 · February 06, 2012 at 8:57 PM

I've found my sweet spot to be eating a huge protein+fat breakfast (a la leptin reset), a moderate protein lunch, and a mostly carbs+fat dinner (mashed sweet potatoes with butter and steamed broccoli for example). This allows adequate protein... (more)

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by 570 · about 17 hours ago

Been Paleo for over a year and feeling good. Have been focusing on exercise (5 primal movements) for about 2 months now and been happy with the results. I'm 5'11, 165-170 (haven't weighed myself for about a month) and look pretty good except... (more)

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Dragonfly 0 · September 26, 2011 at 3:50 PM

I dropped fat when my eating window was smaller--like 4 to 6 hours. I can easily eat over my maintenance level with an 8 hour eating window. Also, dropping "aerobic exercise" frequency & adding in more "moving slowly" can help. Lower... (more)

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by 39841 · about 17 hours ago

As a preface, let me confess that in spite of the fact that people are talking about leptin everywhere I go on the internet, I have spent zero time looking into it (beyond initially finding a simple definition) until this morning. I've always... (more)

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donat 0 · August 13, 2011 at 6:32 AM

The most interesting questions often tend to get buried on PH. I could barely find this again today. I'm just wondering if you tested your hypothesis / yourself with a fruit + extra vitamin C challenge? In particular does the extra ascorbic acid... (more)

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by 13983 · about 17 hours ago

From the book "Mastering Leptin" come these five rules for losing weight and/or managing other hormonal issues: Rule 1: Never eat after dinner. Allow eleven to twelve hours between dinner and breakfast. Never go to bed on a full stomach.... (more)

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animalcule 0 · August 04, 2011 at 8:09 PM

It sure makes sense to me, a skinny person who is oversensitive if anything to leptin (had problems for years with low appetite). I've had the best weight gain results doing almost the exact opposite (eating right before bed, eating giant meals... (more)

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by 205 · about 17 hours ago

Though I eat strict paleo I cannot get the weight to move. I've been reading about adrenal fatigue, leptin-resistance, hormonal imbalances etc. and often come across recommedations to supplement with pregenenolone to get the hormonnal systems back... (more)

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Kamal 0 · July 23, 2011 at 3:07 PM

I am currently supplementing with pregnenalone, 50 mg/day. No effects thus far, but it has only been like a week or so. The recommended pregnenalone dosages vary depending on the reason you are taking it. Why are you thinking about taking it? I... (more)

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by 2565 · October 24, 2014 at 3:42 AM

My question has to do with someone who develops leptin resistance. It's been said that one way to tell if you are leptin resistant is to look in the mirror because you'll have gained significant body fat. But isn't it also true that leptin... (more)

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Vivalapaleo 0 · November 29, 2011 at 11:25 PM

This is really interesting because part of the leptin reset is to do Hiit training - but will hiit training or even weight training drain your adrenals even more if you are past leptin and have Adrenal fatigue?? Given that weight training... (more)

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by 5768 · October 24, 2014 at 3:36 AM

Let's say that an individual decides to implement the Paleo diet and was not leptin resistant prior. However, like most who begin paleo, their calories decrease, they go VLC and still continue or begin a high intensity training program several... (more)

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The_Loon 0 · September 30, 2011 at 3:40 PM

Cells being temporarily resistant to insulin is not the same as metabolic syndrome. VLC eliminates chronic and inappropriate insulin resistance and does not cause it. From how I read Dr. K, leptin resistance is due to a number of factors, but... (more)

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by 1054 · October 24, 2014 at 3:30 AM

I???ll start by saying that I really enjoy reading and participating in this site and I particularly am in awe of its excellent features such as badges, reputation, upvotes, comments, upvotes on comments, etc. I don???t know if this is unique or... (more)

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Stabby 0 · August 05, 2011 at 2:26 AM

(warning, long rambling post, might be repetitive and have errors) The way to resolve the problem of people who have good metabolic health telling those who don't what they can and can't do is resolved by proportioning one's beliefs to the... (more)

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by 1670 · October 23, 2014 at 3:39 AM

I just read this article by dr. Jack Kruse on LR and I'm not sure if I have this. I'm not overweight and I don't crave foods, but I do fast and eat 2 meals a day and when I get to the second one my body just doesn't say stop. If I force myself to... (more)

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Matthew_Caton 0 · May 27, 2012 at 4:55 PM

If you are not overweight, and you are not gaining weight, then you definitely are not leptin resistant. It's good to have one big meal a day. If you are worried about overeating then focus on eating high protein in the second meal, and just eat... (more)

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by 205 · October 22, 2014 at 3:23 AM

Hi! I am a 26 year old female, 157cm tall + weigh 147 pounds (68kg). I have been Paleo for 10 weeks now with the primary goal being fat loss. I have eliminated all sugar, grains and dairy. My daily diet usually looks like this: MEAL 1 - 150g... (more)

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c_dee 0 · October 05, 2011 at 3:34 AM

mY 10 cents: cut the cardio down a bit. You didn't say what kind of cardio you are doing, but 40 minutes seems long for a straight cardio session. If you do need the cardio, maybe make it more intense? drop you last meal. I'm guessing that if... (more)

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by 10 · October 21, 2014 at 4:28 AM

Hi. I have recently seen my leptin resistance go away as my appetite has normalised (first time in my life). I'm really enjoying being free from the constant hunger and worry about food. What I wanted to know is if anyone knows how closely... (more)

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Albert83BCN 0 · August 15, 2013 at 11:25 AM

As far as I know (no doc here, just an educated layperson, based on Dr Kruse ideas and some others), it seems that leptin resistance precedes insulin resistance. Leptin receptors at the hypothalamuns account for the body status of energy. If this... (more)

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by 7292 · October 21, 2014 at 4:28 AM

I am currently reading "Fat Chance" by Dr. Robert Lustig and he talks about leptin resistance and its role in obesity. Leptin, produced in fat cells suppresses appetite and speads metabolism and energy expenditure, yet in obese individuals, they... (more)

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EnglishRose 0 · August 12, 2013 at 8:16 AM

I have never been able to do due to carb/sugar addiction as it just led to a binge so I would first advise make sure you have changed how you eat and adapted. However now that I have changed I have been finding some days I can miss a meal (and I... (more)

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by 252 · October 21, 2014 at 3:35 AM

I know many tried the Leptin Reset protocol trying to be Leptin-Sensitive. But, why, do one need to be Leptin Sensitive? Is there a real scientific theory behind the claim that Leptin-Sensitive is more beneficial to Leptin-Resistant? What is the... (more)

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Beth_WeightMaven 0 · January 04, 2012 at 4:53 PM

It's not inconceivable that there is a beneficial purpose to leptin resistance in the same way there is for insulin resistance. I.e., peripheral insulin resistance is pretty valuable in times of lower dietary carbs to preserve glucose for the... (more)

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by 8979 · October 21, 2014 at 3:28 AM

Rosedale, Kruse and Richards all have theories/recommendations for reducing leptin resistance. What are the differences between these three methods and the advantages or disadvantages of a particular method? Feel free to supply clinical data... (more)

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Anonymous_Chump 0 · December 21, 2011 at 2:00 AM

This fella speaks of leptin, too. Anyone know of his work?

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by 305 · October 20, 2014 at 3:28 AM

Hey there fellow hackers! I am writing a research paper for my nutrient metabolism class on "high fructose consumption and leptin resistance". Could you all point me to some scholarly articles or "original" studies dealing with the subject?... (more)

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cliff_1 0 · January 26, 2012 at 2:38 PM

The only models that have shown leptin resistance with fructose are diets that contain 60% pure fructose, an amount that is basically impossible to consume in a normal diet. It hasn't really been shown in human diets either as far as I can... (more)

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