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by 16858 · March 23, 2014 at 4:42 PM

For MTHFR, are the B12, folate found in liver or egg yolks already methylated? And does cooking damage them? Or are supplements needed? I started on methylfolate in the AM and methyl B12 at night, and have noticed some improvements in sleep... (more)

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by 3277 · December 04, 2013 at 3:29 AM

I'v spent an enormous amount of time and read all kinds of theoretical info about methylation causing excess sulfur and ammonia. Does anyone here have that issue or is this all ivory tower theoretical stuff? Ever since going paleo and... (more)

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by 0 · October 11, 2013 at 6:06 PM

This may be a bit of a long post. Apologies in advance: I wanted to just get it out there. I began taking B12 (methylcobalamin) and folate (methylfolate), & ~2,500 IU D3/ 500mg K2 recently. While the symptoms & dramatic... (more)

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mareserinitatis 0 · October 11, 2013 at 6:06 PM

How much sodium are you getting? I found more sodium, less potassium really helps with the neurological issues I've had (especially tingling).

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by 3277 · January 12, 2014 at 3:56 PM

Pasted below is the lab result for some genetic testing I had done. What the heck does this mean (in plain english please), and Could it have any potential relevance to someone who seems to be having issues with amines/salicylates? Here's the... (more)

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Annika 0 · August 22, 2013 at 10:17 PM

I and several of my family members have MTHFR mutations. They can predispose you to blood clots, cardiovascular problems, and neuro-psychiatric problems. It's a complicated issue and I find it quite difficult to understand. The short version of... (more)

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by 992 · July 17, 2013 at 2:54 PM

While trying to further optimize my diet, I recently noticed that I have a homozygous C677T (TT genotype) MTHFR enzyme. Homozygous rs1801133(T;T) individuals have ~30% of the expected MTHFR enzyme activity, and rs1801133(C;T) heterozygotes... (more)

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Dragonfly 0 · July 17, 2013 at 2:54 PM

Liver is a great source of highly absorbable folate. And some folk eliminate their migraines with a vlc/ketogenic diet. YMMV.

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by 120 · May 19, 2013 at 7:20 PM

I am homozygous recessive for MTRR a66g, which is methionine synthase reductase. According to 23 and me i have lots of methylation problems, but none with the MTHFR gene. Does anybody have a good understanding of this and what I should do given... (more)

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Sara_S_ 0 · May 19, 2013 at 7:20 PM

I also have the MTRR mutation: it's pretty rare. Since this stuff isn't well established, but is based on basic biochemical pathways and as-yet-untested hypotheses, I highly recommend looking into it yourself. The methylation subforum on... (more)

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by 15 · February 25, 2013 at 4:31 PM

Hi Guys, I'm about 2 months into a strict primal diet that does include raw dairy and nuts, but does not include starchy veggies. I look and feel better already and I'm really excited to watch my progression in the upcoming year. One thing I've... (more)

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by 30 · March 08, 2012 at 4:33 PM

After 10-15 years of on and off smoking, I'm done done done. We're getting ready to start a family, and with the switch to paleo, I'm focusing on healing my body after all the damage I've done. Are there any supplements or foods I should focus... (more)

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Dragonfly 0 · March 08, 2012 at 4:21 PM

Congrats! Pregnancy coach here. I generally suggest that moms-to-be skip the prenatal & supplement separately, but do what works for you. I also recommend krill oil supplements, rather than fish oil or CLO. Cellular repair is key, so... (more)

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by 1449 · October 21, 2011 at 9:24 AM

I recently found out (from 23andme) that I am heterogeneous (one copy of the "bad" gene) for the MTHFR C677T polymorphism. This means that my body has reduced ability to convert folate into the active form of folate (5-methyltetrahydrafolate).... (more)

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Gazelle 0 · October 20, 2011 at 9:52 PM

When I got pregnant my doctor discovered I have this "bad gene" too (also confirmed by 23andme) and prescribed Folapro which contains Metafolin, an active form of folate called L-5-methyl tetrahydrofolate. My homocysteine level is around 5 though... (more)