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Hack my RIDICULOUS blood work - 450 LDL? (updated)

by 6629 · December 30, 2011 at 11:22 AM

35 Years old, male, Paleo for 1 year+, no health problems. 185 LBS at 5'9", aprox 10-11% bodyfat.

Had Gall Bladder removed in 2005.

Current medications: Ambien5-10mg

Other Medical Issues: Seborrheic Dermatitis (controlled with Selson Blue). Low Vit D test/Calcium in Feb 2011 (taking supplemental Vit D and Calcium usually).

Diet:Low salt, low carb - Coffee w heavy cream daily. Green Salads w olive\vinegar most days, Eggs 6\day(local farm fresh), Beef and Chicken most days(grain fed), Whey\Casein protein most days, bacon every other day, coconut milk some days, carrots\peas\ zucchini\peppers\sweet potatoes\onions\garlic\broccoli most days. Honey 1/week if that. Blueberries/Strawberry/Black Berries very occasionally. Almond butter sometimes, mixed nuts sometimes (neither around the test).

Activity: Low, Strength Training 3x week (Squats,Deadlifts,Bench,weighted Pullups).

Supplements: MultiVit, Vit D 2000iu/day, Fish Oil most days, Creatine Monohydrate.

Most likely in Keto state during test and previous week. Fasted aprox 20 hrs(nothing but water) and then this:

CHOLESTEROL 506 High mg/dL
CHOLESTEROL.IN HDL 30 Low mg/dL
CHOLESTEROL.IN LDL 450 High
TRIGLYCERIDE 131 mg/dL
THYROTROPIN 1.070 uIU/mL
Free Test 318.5

This is a bit extreme no?

Full Results below:

ALANINE AMINOTRANSFERASE 38 U/L 0-40
ALBUMIN 4.7 g/dL 3.5-5.0 ALKALINE PHOSPHATASE 41 U/L 0-125
ASPARTATE AMINOTRANSFERASE 21 U/L 0-45
BILIRUBIN 0.6 mg/dL 0.0-1.3 CALCIUM 9.4 mg/dL 8.4-10.5
CARBON DIOXIDE 30 mmol/L 23-32
CHLORIDE 98 mmol/L 98-108
CHOLESTEROL 506 High mg/dL 0-199
CHOLESTEROL.IN HDL 30 Low mg/dL >40 CHOLESTEROL.IN LDL 450 High mg/dL <129 CREATININE 1.1 mg/dL 0.5-1.2 GLOMERULAR FILTRATION RATE.PREDICTED 81 mL/min
GLUCOSE 91 mg/dL 65-99
POTASSIUM 4.4 mmol/L 3.5-5.0 PROTEIN 7.6 g/dL 6.0-8.2 SODIUM 136 mmol/L 135-145 HYROTROPIN 1.070 uIU/mL 0.27-4.2
TRIGLYCERIDE 131 mg/dL 0-149
UREA NITROGEN 19 mg/dL 9-20

H

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is the rest of it.

BASOPHILS 0.04 k/cmm 0.0-0.2 Details

BASOPHILS/100 LEUKOCYTES 0.7 % 0-2 Details

EOSINOPHILS 0.24 k/cmm 0.0-0.3 Details

EOSINOPHILS/100 LEUKOCYTES 4.0 High % 0-3 Details

ERYTHROCYTE DISTRIBUTION WIDTH 47.4 fL 39.0-52.2 Details

ERYTHROCYTE DISTRIBUTION WIDTH 14.3 % 11.5-14.5 Details

ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 31.9 pg 27-33.3 Details

ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION 35.2 g/dL 31.8-37.1 Details

ERYTHROCYTES 5.18 M/cmm 4.44-6.1 Details

GRANULOCYTES.IMMATURE/100 LEUKOCYTES 0.00 % 0.00-2.00 Details

HEMATOCRIT 46.9 % 41-52 Details

HEMOGLOBIN 16.5 g/dL 13.9-18 Details

IMMATURE GRANULOCYTE # 0.00 k/cmm 0.00-0.2 Details

LEUKOCYTES 5.97 k/cmm 4.6-10.8 Details

LYMPHOCYTES 2.90 k/cmm 1.2-3.6 Details

LYMPHOCYTES/100 LEUKOCYTES 48.6 High % 25-33 Details

MEAN CORPUSCULAR VOLUME 90.5 um3 80-98 Details

MONOCYTES 0.48 k/cmm 0.14-0.76 Details

MONOCYTES/100 LEUKOCYTES 8.0 High % 3-7 Details

NEUTROPHILS 2.31 k/cmm 1.8-7.8 Details

NEUTROPHILS/100 LEUKOCYTES 38.7 Low % 54-65 Details

PLATELET MEAN VOLUME 11.4 High um3 7.4-10.5 Details

PLATELETS 222 k/cmm 130-440

**OTHER BLOOD WORK BELOW****

MAY 2007:

ALANINE AMINOTRANSFERASE    18  U/L 7.0-52  Details
ALKALINE PHOSPHATASE    65  U/L 40-150
ASPARTATE AMINOTRANSFERASE  17  U/L 5-34
BILIRUBIN   0.73    mg/dL   0.2-1.2
BILIRUBIN.GLUCURONIDATED+BILIRUBIN.ALBUMIN BOUND    0.32    mg/dL   0-0.5
CARBON DIOXIDE  30  mmol/L  20-30
CHLORIDE    105     mmol/L  100-110
CREATININE  1.3     mg/dL   0.5-1.5
GLOMERULAR FILTRATION RATE.PREDICTED    68.4    mL/min  
GLUCOSE 56  mg/dL   <199
POTASSIUM   3.5     mmol/L  3.5-5.0
SODIUM  142     mmol/L  135-145
THYROTROPIN 1.01    uIU/mL  0.35-5.5
THYROXINE.FREE  1.15    ng/dL   0.6-1.6
UREA NITROGEN   17  mg/dL   7-25

BASOPHILS/100 LEUKOCYTES 0.6 % 0-2 Details

EOSINOPHILS/100 LEUKOCYTES  4.1     %   0-7 Details
ERYTHROCYTE DISTRIBUTION WIDTH  13.9    %   11.5-14.5   Details
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 32.4    pg  27-34   Details
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION   34.9    g/dL    32-37   Details
ERYTHROCYTES    5.34    M/cmm   4.7-6.1 Details
HEMATOCRIT  49.6    %   40-52   Details
HEMOGLOBIN  17.3    g/dL    14-18   Details
LEUKOCYTES  6.7     K/cmm   4.5-11.0    Details
LYMPHOCYTES 1.9     K/cmm   1-4 Details
LYMPHOCYTES/100 LEUKOCYTES  27.9    %   10-55   Details
MEAN CORPUSCULAR VOLUME 92.9    fL  80-98   Details
MONOCYTES/100 LEUKOCYTES    8.1     %   2-12    Details
NEUTROPHILS 4.0     K/cmm   1.8-6.5 Details
NEUTROPHILS/100 LEUKOCYTES  59.3    %   40-75   Details
PLATELET MEAN VOLUME    9.6     fL  7.4-10.4    Details
PLATELETS   226     K/cmm   130-450 

*FEB 2008****

ALANINE AMINOTRANSFERASE 91 High U/L 7.0-52 Details

ALBUMIN 4.0     g/dL    3.2-5.0
ALKALINE PHOSPHATASE    59  U/L 40-150
ASPARTATE AMINOTRANSFERASE  41 High U/L 5-40
BILIRUBIN   0.31    mg/dL   0.2-1.2
BILIRUBIN.GLUCURONIDATED+BILIRUBIN.ALBUMIN BOUND    0.14    mg/dL   0-0.5
CALCIUM 9.6     mg/dL   8.5-10.5
CARBON DIOXIDE  26  mmol/L  20-30
CHLORIDE    108     mmol/L  100-110
CHOLESTEROL 186     mg/dL   0-199
CHOLESTEROL.IN HDL  31 Low  mg/dL   >40
CHOLESTEROL.IN LDL  116.6   mg/dL   <130
CREATININE  1.3     mg/dL   0.5-1.5
GLOMERULAR FILTRATION RATE.PREDICTED    68.4    mL/min  
GLUCOSE 86  mg/dL   <199
MAGNESIUM   2.5 High    mg/dL   1.8-2.4
PHOSPHATE   4.0     mg/dL   2.5-5.0
POTASSIUM   4.0     mmol/L  3.5-5.0
PROTEIN 7.0     g/dL    6.0-8.5
SODIUM  144     mmol/L  135-145
THYROTROPIN 1.53    uIU/mL  0.35-5.5
TRIGLYCERIDE    192     mg/dL   0-199
UREA NITROGEN   14  mg/dL   7-25

BASOPHILS/100 LEUKOCYTES 0.4 % 0-2 Details

EOSINOPHILS/100 LEUKOCYTES  6.2     %   0-7
ERYTHROCYTE DISTRIBUTION WIDTH  13.6    %   11.5-14.5
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 33.1    pg  27-34
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION   35.1    g/dL    32-37
ERYTHROCYTES    4.97    M/cmm   4.7-6.1
HEMATOCRIT  46.9    %   40-52
HEMOGLOBIN  16.5    g/dL    14-18
LEUKOCYTES  8.6     K/cmm   4.5-11.0
LYMPHOCYTES 3.0     K/cmm   1-4
LYMPHOCYTES/100 LEUKOCYTES  34.5    %   10-55
MEAN CORPUSCULAR VOLUME 94.4    fL  80-98
MONOCYTES/100 LEUKOCYTES    8.2     %   2-12
NEUTROPHILS 4.4     K/cmm   1.8-6.5
NEUTROPHILS/100 LEUKOCYTES  50.7    %   40-75
PLATELET MEAN VOLUME    9.2     fL  7.4-10.4
PLATELETS   282     K/cmm   130-450

*MAY 2008*

THYROTROPIN 0.937 uIU/mL 0.27-4.2 HEMOGLOBIN A1C/HEMOGLOBIN.TOTAL 5.4 %

BASOPHILS 0.05 k/cmm 0.0-0.2 Details

BASOPHILS/100 LEUKOCYTES    0.7     %   0-2
EOSINOPHILS 0.42 High   k/cmm   0.0-0.3
EOSINOPHILS/100 LEUKOCYTES  6.3 High    %   0-3
ERYTHROCYTE DISTRIBUTION WIDTH  41.9    fL  39.0-52.2
ERYTHROCYTE DISTRIBUTION WIDTH  13.4    %   11.5-14.5
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 32.2    pg  27-33.3
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION   35.7    g/dL    31.8-37.1
ERYTHROCYTES    5.18    M/cmm   4.44-6.1
HEMATOCRIT  46.8    %   41-52
HEMOGLOBIN  16.7    g/dL    13.9-18
LEUKOCYTES  6.68    k/cmm   4.6-10.8
LYMPHOCYTES 1.86    k/cmm   1.2-3.6
LYMPHOCYTES/100 LEUKOCYTES  27.8    %   25-33
MEAN CORPUSCULAR VOLUME 90.3    um3 80-98
MONOCYTES   0.45    k/cmm   0.14-0.76
MONOCYTES/100 LEUKOCYTES    6.7     %   3-7
NEUTROPHILS 3.90    k/cmm   1.8-7.8
NEUTROPHILS/100 LEUKOCYTES  58.5    %   54-65
PLATELET MEAN VOLUME    12.1 High   um3 7.4-10.5
PLATELETS   174     k/cmm   130-440

**MAY 2009*****

ALANINE AMINOTRANSFERASE 53 High U/L 7.0-52 Details

ALKALINE PHOSPHATASE    54  U/L 40-150
ASPARTATE AMINOTRANSFERASE  25  U/L 5-40
BILIRUBIN   0.54    mg/dL   0.2-1.2
BILIRUBIN.GLUCURONIDATED+BILIRUBIN.ALBUMIN BOUND    0.23    mg/dL   0-0.5
CARBON DIOXIDE  27  mmol/L  20-30
CHLORIDE    103     mmol/L  100-110
CREATININE  1.2     mg/dL   0.5-1.5
GLOMERULAR FILTRATION RATE.PREDICTED    74.1    mL/min  
GLUCOSE 61  mg/dL   <199
POTASSIUM   4.3     mmol/L  3.5-5.0
SODIUM  142     mmol/L  135-145
THYROTROPIN 1.36    uIU/mL  0.35-5.5
UREA NITROGEN   16  mg/dL   7-25

BASOPHILS/100 LEUKOCYTES 0.4 % 0-2 Details

EOSINOPHILS/100 LEUKOCYTES  5.3     %   0-7
ERYTHROCYTE DISTRIBUTION WIDTH  13.0    %   11.5-14.5
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 31.2    pg  27-34
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION   34.1    g/dL    32-37
ERYTHROCYTES    5.25    M/cmm   4.7-6.1
HEMATOCRIT  48.2    %   40-52
HEMOGLOBIN  16.4    g/dL    14-18
LEUKOCYTES  5.8     K/cmm   4.5-11.0
LYMPHOCYTES 1.6     K/cmm   1-4
LYMPHOCYTES/100 LEUKOCYTES  28.0    %   10-55
MEAN CORPUSCULAR VOLUME 91.7    fL  80-98
MONOCYTES/100 LEUKOCYTES    6.9     %   2-12
NEUTROPHILS 3.4     K/cmm   1.8-6.5
NEUTROPHILS/100 LEUKOCYTES  59.4    %   40-75
PLATELET MEAN VOLUME    10.2    fL  7.4-10.4
PLATELETS   207     K/cmm   130-450

MARCH 2010****

BASOPHILS 0.06 k/cmm 0.0-0.2 Details

BASOPHILS/100 LEUKOCYTES    0.7     %   0-2
EOSINOPHILS 0.65 High   k/cmm   0.0-0.3
EOSINOPHILS/100 LEUKOCYTES  7.1 High    %   0-3
ERYTHROCYTE DISTRIBUTION WIDTH  13.1    %   11.5-14.5
ERYTHROCYTE DISTRIBUTION WIDTH  41.9    fL  39.0-52.2
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 31.0    pg  27-33.3
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION   35.3    g/dL    31.8-37.1
ERYTHROCYTES    5.39    M/cmm   4.44-6.1
GRANULOCYTES.IMMATURE/100 LEUKOCYTES    0.10    %   0.00-2.00
HEMATOCRIT  47.3    %   41-52
HEMOGLOBIN  16.7    g/dL    13.9-18
IMMATURE GRANULOCYTE #  0.01    k/cmm   0.00-0.2
LEUKOCYTES  9.11    k/cmm   4.6-10.8
LYMPHOCYTES 2.44    k/cmm   1.2-3.6
LYMPHOCYTES/100 LEUKOCYTES  26.8    %   25-33
MEAN CORPUSCULAR VOLUME 87.8    um3 80-98
MONOCYTES   0.45    k/cmm   0.14-0.76
MONOCYTES/100 LEUKOCYTES    4.9     %   3-7
NEUTROPHILS 5.50    k/cmm   1.8-7.8
NEUTROPHILS/100 LEUKOCYTES  60.4    %   54-65
PLATELET MEAN VOLUME    12.0 High   um3 7.4-10.5
PLATELETS   237     k/cmm   130-440

NOVEMBER 2010****

ALANINE AMINOTRANSFERASE 86 High U/L 0-40 Details

ALBUMIN 4.3     g/dL    3.5-5.0
ALKALINE PHOSPHATASE    70  U/L 0-125
ASPARTATE AMINOTRANSFERASE  35  U/L 0-45
BILIRUBIN   0.5     mg/dL   0.0-1.3
CALCIUM 9.1     mg/dL   8.4-10.5
CARBON DIOXIDE  24  mmol/L  23-32
CHLORIDE    104     mmol/L  98-108
CHOLESTEROL 202 High    mg/dL   0-199
CHOLESTEROL.IN HDL  22 Low  mg/dL   >40
CHOLESTEROL.IN LDL  116     mg/dL   <129
CREATININE  1.0     mg/dL   0.5-1.2
GLOMERULAR FILTRATION RATE.PREDICTED    91  mL/min  
GLUCOSE 94  mg/dL   65-99
POTASSIUM   4.2     mmol/L  3.5-5.0
PROSTATE SPECIFIC AG    0.822   ng/mL   0-4
PROTEIN 7.2     g/dL    6.0-8.2
SODIUM  139     mmol/L  135-145
TRIGLYCERIDE    321 High    mg/dL   0-149
UREA NITROGEN   15  mg/dL   9-20

BASOPHILS 0.05 k/cmm 0.0-0.2 Details

BASOPHILS/100 LEUKOCYTES    0.5     %   0-2
EOSINOPHILS 0.22    k/cmm   0.0-0.3
EOSINOPHILS/100 LEUKOCYTES  2.3     %   0-3
ERYTHROCYTE DISTRIBUTION WIDTH  44.0    fL  39.0-52.2
ERYTHROCYTE DISTRIBUTION WIDTH  13.4    %   11.5-14.5
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN 31.3    pg  27-33.3
ERYTHROCYTE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION   34.5    g/dL    31.8-37.1
ERYTHROCYTES    5.17    M/cmm   4.44-6.1
GRANULOCYTES.IMMATURE/100 LEUKOCYTES    0.20    %   0.00-2.00
HEMATOCRIT  47.0    %   41-52
HEMOGLOBIN  16.2    g/dL    13.9-18
IMMATURE GRANULOCYTE #  0.02    k/cmm   0.00-0.2
LEUKOCYTES  9.48    k/cmm   4.6-10.8
LYMPHOCYTES 1.31    k/cmm   1.2-3.6
LYMPHOCYTES/100 LEUKOCYTES  13.8 Low    %   25-33
MEAN CORPUSCULAR VOLUME 90.9    um3 80-98
MONOCYTES   1.12 High   k/cmm   0.14-0.76
MONOCYTES/100 LEUKOCYTES    11.8 High   %   3-7
NEUTROPHILS 6.76    k/cmm   1.8-7.8
NEUTROPHILS/100 LEUKOCYTES  71.4 High   %   54-65
PLATELET MEAN VOLUME    12.0 High   um3 7.4-10.5
PLATELETS   171     k/cmm   130-440

**FEB 2011***

ALANINE AMINOTRANSFERASE 72 High U/L 17-63 Details

ALBUMIN 4.1     g/dL    3.5-4.8
ALKALINE PHOSPHATASE    46  U/L 32-91
ANION GAP   5   mEq/L   4-13
ASPARTATE AMINOTRANSFERASE  38  U/L 12-50
BILIRUBIN   0.8     mg/dL   0.2-1.3
CALCIUM 9.2     mg/dL   8.9-10.3
CARBON DIOXIDE  30  mEq/L   22-32
CHLORIDE    101     mEq/L   101-111
CREATININE  1.02    mg/dL   .64-1.27
GLOMERULAR FILTRATION RATE.PREDICTED    84  mL/min  >60
GLUCOSE 86  mg/dL   74-118
POTASSIUM   4.2     mEq/L   3.6-5.1
PROTEIN 7.4     g/dL    6.3-8.2
SODIUM  136     mEq/L   136-144
UREA NITROGEN   18  mg/dL   8.0-20.0

Calcidiol 25

DECEMBER 2011 is at the very top.

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14 Replies

Af1d286f0fd5c3949f59b4edf4d892f5
5
18236 · December 29, 2011 at 11:04 PM

Bill,

You are producing LDL at too high of a rate and not clearing them. I would get off creatine, reduce dairy fat, and add low to medium resistance exercise to your weight training regimen. Personally, I added 3x per week jogging and still maintain weight lifting 4x per week. Usually I jog on my rest days, and I almost always jog in a totally fasted state (like on a weekend mornings before breakfast or before dinner on weekdays).

Also, I would consider your thyroid as others here have mentioned. You may need to get a full thyroid test. Poor thyroid function can easily mess up your LDL, which brings us to our next point. I am almost certain that you have very very low LDL receptor activity. This is why your HDL is on the floor and your LDL is in the clouds. It is a vicious circle. Your diet and workout routine is strikingly similar to mine. And while I've never had LDL that high (mine is always about 160-180), we have a similar issue with the bad ratios.

Here is what I would do first if I were you:

  • No Creatine

  • Very little dairy (perhaps for a time)

  • Add cardio and preferably in a fasted state to specifically target and burn FFAs

  • Add some turmeric to your diet somehow. This has been shown to increase LDL receptor activity.

  • Reduce the strain by reducing the weight in your weight lifting. (For example... I was doing 5 reps of 285 twice on the bench, and using EVERY ounce of muscle and girth within me to do so. But I switched to 8-10 reps of 250 for the first set, and 8-10 reps of 200 for the second set). This is just an example for me. But I think you get the idea. To repeat my first sentence here, what I am saying is... reduce the strain by reducing the weight in your weight lifting. I am not sure if this helps with lipid numbers, but I just know that after a full year of nearly maxed out workouts, my numbers were not good at all. I posted a question about it here a while back: http://paleohacks.com/questions/75513/could-lifting-weights-to-failure-regularly-be-problematic-for-blood-lipids-due-to .

Hopefully some of this helps. Keep us posted.

-JK

85026a0abe715229761956fbbee1cba0
4
77338 · December 28, 2011 at 7:16 PM

I'm not qualified to hack this, but have you taken a look at this? http://www.marksdailyapple.com/how-to-interpret-cholesterol-test-results/#axzz1hrHmi35m

07c86972a3bea0b0dc17752e9d2f5642
3
3142 · December 30, 2011 at 1:16 AM

My personal experience:

I had a ton of problems on low carb paleo including low thyroid and skyhigh cholesterol (350 ldl) I was eating full fat cheese and yogurt, a couple servings a day. My doc ordered me off all dairy to help balance my hormones and my cholesterol fell back to normal before my thyroid improved at all (that was a few months of starches that eventually did the trick). So my thyroid may have made it worse but it wasn't the major cause.

I never cut back on meat fat and kept eating plenty of beef and bacon and even cooking in coconut oil. So it was absolutely the dairy fat that caused the up and downs in my cholesterol. Some people just shouldn't eat it, like how others just can't eat gluten, nuts, eggs, shellfish, etc. because of reactions.

3c6b4eed18dc57f746755b698426e7c8
2
5100 · December 29, 2011 at 7:03 AM

How much Creatine Monohydrate are you taking? That is throwing some #s off, especially your creatine and GFR. Your cholesterol #s shouldn't be affected too much by this, although your LDL could increase by as much as 10% just by taking CM. RU a bodybuilder? How long have you been on it?

Did you have fatty liver before starting Paleo? How much weight have you lost? Or how much LBM did you gain through Paleo, exercise and CM supplementation AFTER 11/2010. Your blood test in 11/2010 shows liver-related metabolic derangement. What were your ALT and AST, then (~50 or higher)? Your current liver enzymes should be much lower but your ALT is 2x your AST, common in recovering fatty liver sufferers. It should fall to about the same level as your AST.

Second, were you sick (had a flu or infection / allergies) when you took the test? Your WBCs are jiggered all over. Retest to make sure the WBCs are within range, and rule out something more serious.

Third, you have a normal platelet count but high mean platelet volume. This could again be inflammation/infection but I'd retest when you recover from a flu or infection.

Now, when you combine all these with your LDL, they do increase the risk of CVD (incl. stroke). I'd try to see if you have additional, independent risk factors of CVD (hypertension, high platelet vol, Lpa) along with inflammation markers (CRP, IL-6, Ferritin, Fibrinogen, etc.). If you have the same #s as before (incl. your WBCs, platelets) plus high CRP, ESR, Lpa, etc., I'd be very concerned.

First order of bidness: (-1) Check your prior labs for liver enzymes to see if you had NASH. (0) Quit CM ASAP. (1) Retest lipids and CBC but after you're cleared of a flu or whatever you're suffering from. Add CRP, ESR, and inflammation markers as items. (2) Take particle size test (VAP) to assess your Lpa and ApoB. (3) If LDL is still high, have your genes mapped with 23andme and confirm your ApoE4 status. Take the result to a cardiologist along w/your new CBC / inflammation result. (4) If CBC items r abnormal and confirmed by inflammation markers, you need to be referred to a specialist for further screening.

Cbda678b2a6bf0537d8c4ea0ce8aa9ad
2
4232 · December 28, 2011 at 8:08 PM

Just some things that I do which raised my hdl a lot and lowered ldl and trigs. Lots of Coconut oil (cold pressed, organic, etc). Grass fed animals... saturated fat from aforementioned animals, canned sardines, salads, eggs... Herbs like olive leaves, green tea, hibiscus, hawthorne berry, camomille, cayenne pepper, rose hips comfrey

0e3168ef5f01795bf9905397024bc4c0
2
20 · December 28, 2011 at 7:49 PM

You need to get a complete lipid panel with the apolipoproteins & particle numbers plus genetic markers. Also you should always do your follow-up checks with the full breakdown as well. Just getting a standard profile like this leaves a lot of missing information. You have a form of hyperlipidemia that will be difficult to follow with a standard lipid profile.

Based on the remaining information, it does not appear that the 20 hour fast created any artifacts in your results, so you can assume the results are accurate unless there is more info you have not shared such as intense exercise, etc. prior to the test.

3c6b4eed18dc57f746755b698426e7c8
1
5100 · December 30, 2011 at 11:12 AM

Let's say u had your gallbladder taken out in 2005. That would make sense as your liv enzymes fell to the teens in 5/2007. However, they rose to fatty liver levels in 2/2008, when you supposedly became overweight at 240 lbs. Were you overweight/obese in 2007 and in 2005 as well, when you had surgery?

If so, that's probably fatty liver due to SAD: processed carbs as shown by 192 trigs -- it's not bad but this was prior to your weight loss in 2009 via "slow carbs" (beans but no dairy), when your liv enzymes were halved. No cholesterol #s here but I trust they were normal at this time.

Your #s went bonkers in 11/2010 when you hit 320 trigs w/high liver enzymes. This was your zero-carb, meat only diet; you weren't doing dairy and non-meat SAFA like u are doing now. But your LDL wasn't bad (116). U must have had episodes of running to the bathroom, eating that much fat without the gallbladder.

In short, it seems to be Apo E4. You hit FH territory (TC>=350) with SAFA. I'd try taking out all non-meat SAFA as posted above and see how you fare. U can quickly confirm your Apo status through 23andme for $200. Also take out coffee and CM. I'd increase carbs to about 150-200g using yams, sweet potatoes, peas, and lentils, if they don't bother u. That should reduce your TC and at least turn your LDL to type A. For that to happen, though, your HDL has to go up and trigs have to go down.

If not, the only option I see is increasing carbs more. That's because you have additional issues:

Your creatinine is chronically elevated and this is not due to CM. Seems like your BP was not under control back in 2007-8: GFR of 68 when you were only 30, very similar with another poster here, Berger. U have hypertension? Your doc must've talked to you about low kidney function? Hypertension is a separate risk factor for CVD.

You have a consistently high mean platelet volume, another risk factor of CVD that affects blood clotting. I'd get tested for Lpa and Fibrinogen: they could be similarly elevated.

WBC abnormalities could just be noise but keep an eye on them, since they're more often out of the range than not when you're supposedly healthy. Ask for inflammation markers like Ferritin, CRP, IGF-1 and ANA to rule out autoimmunity and other conditions, since u r complaining of unexplained fatigue. Watch out for increased risk of colorectal cancer for those with no gallbaldder.

Very low HDL throughout, even when exercising. Like above, more cardio vs. weights, more reps vs. heavy weights. For u, trigs may not serve as a marker of insulin as it does in most people. No blood sugar issue but u seem to become hypoglycemic when fasting (back in 2007-08).

Your doc will recommend a low-fat diet, citing your missing gallbladder. If your #s don't improve, I'd opt for a lower fat (i.e., higher carb) diet with lean meats, no dairy & eggs, given your risk factors that do require attention.

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240 · December 29, 2011 at 1:25 PM

Try this; ditch that coffee; especially if its french press or expresso.

4 years ago, when 50 pounds heavier, my TC was 220. October this year (2 years primal) TC=530! (tested twice due doctor disbelief)

Dropped my daily 6-8 large cups expresso/french press. (I knew this addiction was not 'ancestral'! but it helped my daily 16 hr 'IF').

Last week: TC 230.

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2902 · December 28, 2011 at 7:56 PM

Genetics are a bitch.

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1031 · December 29, 2011 at 2:01 AM

In addition to getting a VAP or NMR lipid profile, I would get a complete thyroid panel done to include total T4, T4 free, T3 total, T3 free, reverse T3, TSH

I would not be surprised that you are hypothroid. Cholesterol levels are higher than normal because the body's inability to produce T4 that breaks down cholesterol when hypothroid You also need a 4x salivary cortisol test done as cortisol levels during the day give hints as to how to treat hypothroidism.

There is really nothing you can do diet wise if you are hypothroid. Get your thyroid issues straightened out and your lipid profile will be better. Many folks find they cannot do any dairy to include whey. Some fortunate ones can do all the dairy they want with no ill effects. Low carb diets seem to reveal hypothroid problems that were masked by the previously eaten SAD diet. This is why many people feel so sh@ty when discovering paleo and going low carb. They add back in a couple hundred grams of carbs and all is well...except for the relationship of hypothroidism and Cardio Vascular Disease.

There is a dearth of physicians that really understand how to treat thyroid problems.

You can also do Dr Kruse's Leptin Reset Protocol. He says than many thyroid problems are corrected by becoming leptin sensitive...but if the thyroid has shut down then the reset will only mildly help.

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1977 · December 28, 2011 at 11:11 PM

Get a genetic test to see if you have familial hypercholesterolemia, high total and ldl cholesterol points towards this.

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8883 · December 28, 2011 at 8:07 PM

I'm afraid your diet isn't very airtight, Bill. Lots of omega-6 in there. Do you take any supplements?

I would definitely cut out the whey and the casein. As an anecdote : there is nothing that gives me more acne than whey and casein (especially whey). I don't see why people always take it : what's the point, really? Just eat a good steak and you'll have all the protein you need... Use gelatin if you really want a shake. You'll spend less and you'll be healthier. WIN-WIN

That being said, if you've been paleo for more than a year and haven't eaten liver or loads of vegetables, there's a good chance you got a copper deficiency. While butter might be a plausible explanation for this, I believe such a deficiency is even more plausible.

Another thing you should absolutely consider is lack of activity. My father has bad cholesterol, since he started walking a lot it has improved a lot. And his diet sucks, believe me (loads of bread, he eats constantly, ... the only thing that is good is his 5 portions of fruit).

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19504 · December 28, 2011 at 7:48 PM

I think the test is wrong. My friend had a similar problem after fasting for three days. Maybe the doc will let you retake? Then fast for just 12 hour and drink water...

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77338 · December 29, 2011 at 3:47 AM

1.) THERE IS LITTLE EVIDENCE THAT ELEVATED TOTAL CHOLESTEROL IS ASSOCIATED WITH ATHEROSCLEROTIC DISEASE. 2.) A LOW HDL HAS BEEN SHOWN TO BE ASSOCIATED WITH A POORER PRGNOSIS ONLY IN INDIVIDUALS WITH PREVIOUSLH DIAGNOSED CAD. 3.) THERE IS ONLY MARGINAL EVIDENCE THAT DIETARY INTAKE OF CHOLESTEROL IS RELATED TO TOTAL OR HDL. 4.) I DONT KNOW HOW KNOWING YOUR VLDL, OR LDL WOULD PROVIDE USEFULL INFORMATION, BUT I AM LISTENING!? 5.) IF YOU ARE ANXIOUS ABOUT CHOLESTEROL DOGMA, THEN THERE IS LITTLE MAGIC HERE, DOGMA STILL SAYS LIPITOR, LOW CHOLESTEROL DIET, AND MAYBE HIGH DOSE NIACIN.

I AM GUESSING THYROTROPIN IS TSH. IF SO IT IS STONE COLD NORMAL. KNOWING T3, T4, etc WILL ADD ONLY CONFUSION.

I HOPE THIS HELPS.

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