I've been having some rosacea issues recently and suspected it was due to gut problems, like SIBO or something pathologic somewhere in the G.I. tract The SIBO result (from a separate test) was positive, with mild bacterial overgrowth. I've been fairly strictly paleo for three years, but have a history of antibiotic use for acne.
My results from the CDSA 2.0 were mostly maddeningly normal - plenty of Bifido and Lactobacillus bacteria present, good fat distribution, pancreatic enzymes, etc. The exception was beta-glucuronidase, which was sky-high. Reference range is 337 - 4,433 U/g, and my result was 28,746 U/g. This didn't seem to bother my PCP, who talked about it being a problem if it was low but nothing really if it's high. That seemed kind of hinky to me.
From a bit of digging I find out that high BG can sabotage one of the main detoxifying mechanisms in the body. Specifically, the liver binds different "toxins" and hormones with glucuronic acid and releases them in the bile to the intestines to be excreted. The BG unbinds these toxins meant for excretion and sets them free to be recirculated in the enterohepatic cycle. Sounds like bad news to me and seems like it could account for some skin problems if substances that should be leaving the body are being recirculated, exacerbated by bacterial overgrowth in the small intestine.
Or this is all crap, no pun intended, that I've patched together through the magic prism of the internet. Which brings me to my question: Has anyone used this test personally or professionally, and do you know how much of a concern high beta-glucuronidase is? It sounds bad, but I wasn't even aware of its existence until about nine hours ago. I'm considering taking calcium d-glucarate, which apparently neutralizes BG, until I can get more glucuronic acid from vegetables and fruits (I'm in a relatively restrictive phase of the GAPS diet at the moment).
Thanks in advance for any of your experiences or knowledge.
Sorry, I don't know the test, but I was reading this today:
On page 2, the authors mention omega-3 from cod liver oil helping with SIBO and acne. I would try fermented cod liver oil, since it has been reported as great for many health issues. The one from Green Pasture is considered the best one.
I know this question is quite old now, but I've just had a CDSA test done (ordered via an ecological medicine/GAPS practitioner doctor) and have had some really abnormal things come back from it too (however my beta glucaronidase levels were one of the few things that were within the test's 'reference range'!). High levels of faecal fat, very low levels of bifidobacteria and high levels of streptococcus, staphylococcus aureus and enterobacter cloacae. :-(
According to the commentary which came with my test, beta glucaronidase is produced by E Coli, Bacteroides and Clostridia. Do you know whether you have abnormally high levels of these bacteria? If you're doing GAPS, this should help with any bacterial imbalances so hopefully this problem should diminish over time if you get any overgrowth or dysbiosis under control.
This document from Genova gives advice for reducing beta glucaronidase levels, although I expect you've probably already seen this. It includes things like eating more fibre, citrus fruits and cruciferous vegetables and supplements like milk thistle.
Maybe if you're still concerned and have the cash, you could retest further down the line to see if it's improved.