I really, really enjoyed this presentation. It's a great 101 on the gut and auto-immune disease. Given how much he dumbed it down for a lay audience (with all sorts of familiar metaphors) I suspect someone with a more expert knowledge may cringe, but it worked for me.
I particularly found the discussion about the differences between allergy, sensitivity, and intolerance helpful. For example, the skin prick tests only check for IgE anti-bodies and there are three others involved. Similarly, some blood tests only check for a specific gluten peptide, but there are lots of others. Finally, intolerance is neither an allergy or a sensitivity but an inability to digest a nutrient and thus create problems (like lactose intolerance as a result of the enzyme lactase).
He also has a great section in there which talks about the three things necessary for an auto-immune problem: a genetic susceptibiltiy, an environmental trigger (like gluten), and a leaky gut. If you have the latter two, then the result depends on the first. It could be celiacs (gut), but it could also be hashimotos (thyroid) or ADHD or autism (brain).
Interestingly, he's not down on all gluten and says the problematic one is the one in wheat, barley, and rye.
The promo for the supplement was way at the end of it and Sean brought it up. The goal of the supplement is to nutritionally support the healing that needs to occur after gluten is removed ... you can do this with a healthy diet, but for some folks, supplements can help this occur faster.