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What: The Paleo Summit (see also this post)

Who: Chris Kresser – Integrative Medicine Practitioner

Topic: An Update on Cholesterol. The cholesterol hypothesis has its staunch proponents as well as its skeptics. So who’s right? Chris presents the latest research demonstrating why elevated cholesterol scores should not be dismissed by the skeptics. He also explains why a high cholesterol score is not always cause for a prescription.

What did you think of this presentation?

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Beth, are you planning on doing a Paleo Summit wrap-up thread? I have so many general thoughts, it would be nice to see what others are thinking too. Like: How has the Summit changed your mind about what you eat and what do you plan on doing now? – Karen P. Mar 1 2012 at 19:35
Great idea! Will do. – Beth-WeightMaven Mar 1 2012 at 23:15

10 Answers

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Honestly my favorite part was when he said he needed to take some things down off his site because he's found out contrary information. He actually stated he was wrong. Ton of respect for that. Makes me trust his opinions even more.

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That's what I like about the guy. – ROB Mar 2 2012 at 0:52
What did he take down? – Patrik Mar 2 2012 at 7:10
It was in reference to LDL particle size tests. Previously, he was willing to rely much more heavily on them, but now is of the opinion that they aren't necessarily all that reliable or accurate. – j3wcy Mar 2 2012 at 13:57
Yep, his ability to turn his skepticism upon himself is what has made him my go-to paleo authority. – Coja Mar 13 2012 at 23:21
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I gotta question...If all you non doctors out there have the drive to take time out of your day to learn about the nuances of cholesterol and the obvious competing theories and problems with the current paradigm WTF are YOUR DOCTORS DOING RIGHT NOW!.....Seriously skip one F'n lunch with your drug rep and listen to some freakin common sense based on CURRENT science! I hear about the side effects of these statins so frequently it makes my head spin. Make sure someone needs em before you prescribe them PLEASE!

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9

I hope everyone who's participated in one of the cholesterol threads here at PH listens to this update. Chris is not an alarmist but he doesn't give medical tests a free pass either. I know I for one feel much better equipped to discuss results with my doctor after listening, and I had already followed the series he released with Chris Masterjohn.

My vote is 5 stars for this one.

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Awesome Talk. An update on cholestrol is great for Travis, Jack and others (though maybe too simple for them). At least has some good quotes.

Eat low PUFA consumption, nutrient dense high antioxident rich foods, exercise and stress managment.

Very understandable talk on a not so easy subject.

Talks about not getting LDL particle size test... Tests are currently too variable (amongst tests)... Also studies inconsistent. except for the fact that small LDL is bad.

Likes LDL /HDL to be under 3 and better under 2. (He actually said Tcol/HDL but later corrrected it)...

total in 300-350 is bad if HDL is normal...

Tests are only accurate to 35 mg either way... So 235 could actually be 200.

If cholestrol is in 250-275 range get tested 2 more times (Over period of time???)

go to doc

screen for infection, inflamaton, micronutrient deficenyu, Full thyroid panel.

Other recs as well...

A great to watch video.

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Chris is quickly becoming my go-to guy. I absolutely trust his perspective and respect his advice. Much like j3wcy's comment, the fact that he's willing to revise his advice doesn't detract at all.

I had a hard time wrapping my head around all the cholesterol info. Reading Chris Masterjohn's website was helpful, but a bit too dense for me to absorb in one sitting. This presentation helped me put all the pieces together.

When Chris mentioned that a better predictor for risk factors is Total Cholesterol/HDL, I immediately found my latest numbers (actually paused the presentation!) and came up with 2.75 (under 3 is considered good, 2 or under is ideal). This made me feel better, but can see that I might have some work to do. Of course, that all depends on where I was in my natural variations in cholesterol numbers that particular day last November, as Chris goes on to describe.

This is one of my faves so far, right up there with Dr. Thomas O'Bryan's talk on gluten. In general, I'm finding the specific topics more educational than the general ones in this summit.

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Chris made a mistake on this; he meant LDL:HDL, not TC:HDL. see the comments here: carbsanity.blogspot.com/2012/03/… – Andy Mar 2 2012 at 1:05
oh, and Dr. Harris comment there regarding lipid markers is facinating (as ususal). – Andy Mar 2 2012 at 1:06
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That makes sense to me....and brings us back to the fact about these labs...we're just guessing folks ;). They are educated guesses based on best current science but we are FAR away from resolution. – JayJay Mar 2 2012 at 2:37
BTW...Kurt doesn't say anything about skinny low carbers (the effect low carber docs are looking for). – JayJay Mar 2 2012 at 2:40
I find Dr. Harris' last comment quite interesting as there was a question on it recently....so does he expect obesity/overweight to be the sole predictor of CV disease? That is quite what his comment sounds like. – JayJay Mar 2 2012 at 2:44
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I thought he was kind of a boring speaker, but then I found myself replaying portions and then I just started taking notes. Nerds rule.

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I really enjoyed his talk, my favorite of the 'paleo summit so far. I thought it was a fantastic summary of the research and the Masterjohn podcast interviews.

One question, he made the statement that Leptin signals LDL uptake by LDL receptors.  If you are LR, the receptor signaling is blocked. Dr Kruse has also made a similar statement in his blog.... I'm sure it is true, I just haven't found a reference. I have found papers that say leptin

  • Decreases hepatic cholesterol synthesis, promotes hepatic uptake of plasma cholesterol (VanPatten and others 2001)
  • Is an important regulator of HDL cholesterol (Lundasen and others 2003)

Can anyone find me a link for a study showing Leptin regulates LDL receptors?

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Maybe referring to the leptin knockout mice referred to here in this review scribd.com/doc/83454391/… lemme know if you want to read the papers referenced. – Bread-Eating Beelzebub Mar 2 2012 at 7:30
here is one that is already free jbc.org/content/276/40/37402.short also you get better results if you search for " lipoprotein receptor " rather than LDL – Bread-Eating Beelzebub Mar 2 2012 at 7:37
Thanks Melissa, I will read the Beltowski paper. The second one I had found but it seems like they are saying leptin might have some impact on plasma cholesterol metabolism, but through an LDLR-independent pathway. Good idea with the better search term too, thanks. – Jeff Mar 2 2012 at 14:45
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Only show so far I took notes while listening. Planning to take to the doc (cardiologist) next week.

What I am going to do differently after hearing this is cut back on supplements, cancel a VAP test, and get checked for FH. My lipid panel numbers mesh perfectly with that profile.

I also have a full thyroid panel ordered, plus Vit D, ferritin, and a few more and I have an appt with Chris coming up soon.

Chris is the best, if you ask me.

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I listened to all parts of Kresser's podcasts with Masterjohn as guest. This PaleoSummit with Kresser is a brilliant summary of Masterjohn's 3-part podcasts. Very very worth listening to by all Paleo Hackers who wish to contribute on threads regarding cholesterol!

Top shelf!

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I think Chris is my favourite voice in paleo health. I have listened to all of his podcasts & trust his view as he is a self-confessed nutrition nerd who spends a lot of time reading the latest research.

Like others, I found this to be a lot easier to understand than Chris Masterjohn (who obviously knows a TONNE about this subject) which allows it to become more accessible.

I also really like his ideas on leaky gut & it has helped me deal with a lot of issues that, previous to listening to his podcast, I didn't realise were related to a compromised digestive system.

I highly recommend!

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