Has anyone tried TMG, Folate (NOT folic acid it MUST be L-methylfolate-Metafolin) B6, B12, Inositol and Choline? Those are the classic supplement combinations for treating histamine issues. After 11 years of doctor to doctor, test after test, I self diagnosed myself to one of the 30% of the population who have the inabilty to convert Folic acid to the methyl doner needed to break down histamine. Has worked like a charm and was almost instant relief from the first dose! These supplements are a HECK of a lot cheaper than the DAO supplement on Amazon.

Good luck to eveyone!!

I can't find any sources for this via Google, but I wonder if it's possible for the immune system to develop antibodies to DAO... I guess it's possible that you have histamine intolerance because your body can't produce DAO without it being attacked by your immune system, but I can't back that up with any science.

I bought DAOsin (cheaper than Histame, $15/30 capsules on Amazon) last week more as a diagnostic tool to see if I even have histamine intolerance, which is silly I know, but histamine intolerance was near the end of a long list possible causes for my flushing and weird reactions to meals and I was a bit desparate, and none of he other usual supplements (Vit C, Qercetin, B6) seemed to help. I can't really tell if it's working. It's been just as fickle of an experiment as anything else. Sure, I haven't been that symptomatic since taking it, but I've been fine for weeks on end too before histamine intolerance was even in my vocabulary. In any case, I think you might want to investigate a serious gut healing protocol as it seems to be the only path out of a diet that's becoming more and more limited and frustrating.

People have different reaction to DOA, it DOES really help some people and they use it for emergencies or when they travel. Others who are really sensitive react to the fillers in the supplement. Have you considered seeing Dirk Budka? He's an MD who runs a clinic in London that deals with histamine intolerance and other gut/intolerance issues. People with HIT seriously fly across the Atlantic to see this guy. As a side note, he is making a new supplement called HistRelief that is more powerful and contains no fillers. I believe it's coming out in May.

I'd like to add my pennyworth re Histame. I find it helps, but is not the total answer. I can't help feeling if it were cheaper and one could afford to take about 10 capsules a day it would be worth taking. I usually take two, four or even six capsules with an allergy tablet as well, that gives a better result than Histame alone. Not ideal I know, but when one is desperate......

Hoping someone with direct experience will reply about DAO (I've already read the Amazon reviews), but to those who've tried, TY. I underwent experimental therapy with live organism helminths in 2010 for an unrelated issue, which improved; around that time I also went paleo, and added many high histamine foods to my diet. I got significantly worse, so under medical advice I eradicated the helminths. No change. I made a dietary connection recently, and I too think gut dysbiosis is at the heart of the issue. Unfortunate that the helminths didn't help the issue, but I may revisit the issue again with another species after I consult with my GI.

Hello, can someone please follow up on use of DAO? Its very frustrating to find that someone is trying something, and then they don't report on their long-term experience. It sends a strong message that the substance/product is a waste of time, but it could also mean that the success was so profound that the person has gone on about their life and forgotten about reporting thier success. We in the trenches have no way to know the difference! Amine intolerance is something that has kept me from paleo. Please help me and others by checking back in about your experience. TY!

Just so you guys know. I tried histame yesterday and i used to fall to the ground in the bathroom after eating any dairy or eggs, couldnt have gluten either but it wasnt as bad. Let's just say today I ate a pizza a burger and chocolate and eggs for breakfast. It sucks that ppl aren't saying histame works but it is a god send for me. Give it a shot. I feel like i can live again, it was worth spending the money to experiment on it. I had lost almost all hope and this was my last go at it. Thank god I tried it.

For yeast and persasitic overgrowth I would limit your carbs. which many of you are doing. Make sure the kefir you are drinking is low carb because if you look at he back it got like 24g of carbs in it. I would increase fermented foods such as kambucha and sourcrout. Increase Saturated and Monousaturated fats and take a full spectrum digestive enzyme before meals. A lot of these reaction can also be related to leaky gut syndrome.

Dr. Daniel Pozarnsky, DC http://www.balancechiropracticandrehab.com

BTW, ayone who is interested in trying the DAO supplement check out Swanson's Vitamins they have their onw brand called DAOSin 30 caps for $39.95.

I have not tried DOA but have ordered MANY MANY times from Swansons. Highly reputable company.

TJ, any updates on the DAO?

I have to ask this question. I just read about histamines in food tonight and I am wondering if this could be my issue also. I looked at buying Histame, but the price put me off. So I am wondering if anyone can answer this. Why can't I just take a nightly Bendryl? (They make me sleepy, but I am fine the next day.) Won't the antihistamine help offset the food histamines?

hi, having the same problems & some one told me that it might be this! so my question to you all is has anyone tried echinacea! it's suppose to be a natural anti-histamine.. the only problem is you can only take it for 8 weeks then you have to have a 2 week break but it's a lot cheaper than the tabs your getting! im gonna have a try..

I got a free sample of Histame about 6 months ago. What caught my eye was it said for food allergies so I requested the free sample. They absolutely work for me within a few minutes. Because they are so expensive I only take them if I have a major sneezing attack after eating. So far they haven't failed me. As a side note, years ago I went through a series of shots at the doctor’s office because I got terrible migraine headaches which were finally diagnosed as "histamine" migraines. I wish I could figure out why my body over reacts to histamine. But whatever the case the Histame pills work great for me.

Ya'll might want to look into mast cell activation disorder. It's a relatively new clinical entity so not well known yet, but involves overactive mast cells, which of course pump out histamine along with about 200 other chemical mediators. There's a lot of overlap of symptoms between that and histamine intolerance.

I also get flushing, sinus problems, headaches, heart racing, and occasionally itching after eating sometimes, and my doctor thought it could be histamine intolerance, so I started looking into it.

I tried Histame, mainly on the idea that it might mean something if it helped. It did make some difference, although it by no means fixed me. Maybe if I could afford to take half the bottle at a time, but I never tried that. Nonetheless, it seemed to help some.

I've discovered that taking betaine HCL often knocks out my symptoms pretty much completely. This may be completely idiosyncratic, but it seriously works. I don't know if the extra acid breaks down the histamine before it gets to my intestines, or if it kills off nasty bacteria or yeast or something in my small intestine, or something else, but it makes a huge and noticeable difference. I started taking it for acid reflux problems (which it also helped) but then I noticed that my increasingly-common flushing after many meals went away!

I took the HCL for awhile, ratcheting down my dose whenever it seemed to make my symptoms worse instead of better. I was off it for months before my problems, both the reflux and the flushing, etc., started to come back. Doing another round of HCL helped again. I've gone through a few cycles and it always seems to work, though never truly permanently. Something to consider!

I had some genetic testing done because I have a Mast Cell Disease (Systemic Mastocytosis) that gives me SEVERE "allergic" reactions to just about everything. But get this...I'm NOT ACTUALLY allergic to all this stuff. I've been tested for just about everything under the sun. I'm allergic to a couple of things but not many.

I've been living on a low histamine diet because my Immunologist and I noticed I was reacting to LOADS of high histamine containing foods. Now, one day I can eat spinach and be fine; and another day I eat spinach and I need an epi pen and medical intervention. What gives??

So, I've learned that on a SPECIFIC GENE, on a SPECIFIC allele you can tell whether you are one of those people who have this marker for low DAO (diamine oxidase) one of the enzymes responsible for degrading histamine. So I went to my test results and had a look...guess what? I am.

So is THIS why I REALLY having "allergic reactions" to foods??? And does it have NOTHING to do with my Mast Cells having a dumping party in my blood stream? Or is it both?

And what do I do about it?

I started taking DAO for my migraines. My assumption is that I have a histamine problem more than anything. I'm about 80% paleo but more like 60% around the holidays. I am still taking my regular migraine medication but still have seen a reduction in frequency of headaches since supplementing with DAO (daosin). I take it only when I eat terrible delicious food like ice cream/ GF pizza or when I'm out at a restaurant. I will definitely agree... it is in no way a complete solution and I won't ever take it everyday. Probably the best option is to moderate high histamine foods.

Hi

My wife and I both suffer digestion problems - IBS etc.

I also had bacterial dysbiosis.. In UK you can get it tested for in London at BioLab. The consultant who referred me is Professor Brostoff.

Anyway even after test he recommended a new antibiotic which wasn't released in UK and had to use Metronidazole instead. It works for a month or so and is nasty stuff.

My wife kicked off badly sometime ago and I asked my parents holidaying in India to buy some Rifaximin. Gave it to the wife and hey presto her symptoms of bloating, pain etc were 90% improved. Still that way 9 mths on.

It's an antibiotic worth trying because it works directly in the gut, very little is absorbed into the bloodstream.

I've tried DAO - don't just assume you are intolerant to Histamine or lack DAO. It could be another allergy and histamine in the diet is exacerbating the primary allergy symptoms. All DAO is doing is neutralising the dietary histamine to prevent the additional aggravation. I use it for that..if i have pizza, beer, wine etc.

I think I have a slight allergy to dairy, when I have high histamine foods it makes it much worse so DAO helps dampen the effect.

My tuppence worth if it helps anyone.

I'm in Canada, and recently found this site to offer the most reasonably priced DAO supplement: https://www.swansonvitamins.com/swanson-ultra-daosin-300-mcg-30-caps They also shipped without charging both an arm and a leg, and the package arrived quickly.

My histamine intolerance re-appeared after going paleo almost two years ago. Although a low histamine diet should be the first defence, I do find the supplement helps for those occasions when eating out, or over the holidays.

Hi all with the histamine problems.....I haven't tried the supplement yet but plan to do so. Many of your symptoms sound like Mastocytosis which can be in the skin with many/various itchy rashes called Subcutaneous Mastocytosis or it can affect the organs which is more serious. I have the skin problem which can be hell but now I am seeing a specialist in Toronto who knows about this condition. The bad news is it is very rare and not all docs are aware of it. Just google it. There is a wealth of information at www.mastocytosis.ca photos can be seen at www.flickr.com/photos/mastocanada.

There are tests to determine the severity....Serum Tryptase blood test along with others is key. You can still have it even if this test is in normal ranges. Proper skin biopsy could do the trick also but you have to know the technique.

I see a specialist dermatologist....He has prescribed H1 and H2 blockers to keep it under control...and it helps...150 mg ranitidine twice daily with 10 mg of Reactine per day. In USA there is another antihistamine...forgot the name which is the same product....your pharmacist will know. But better to see a specialist for proper diagnosis. Most important stay away from aspirin and all pain killers with aspirin/salycilates and minimise foods/supplements/herbals/medicines high in salycilates. Remember..not everyone will have this condition but it is important to get checked with your doctor for proper treatment. Good Luck.

I've found xylitol to help with the anti-fungal part. 1/4 tsp twice a day. Though more (up to 50 grams a day) is fine.

my main problem is with mold! the lower the mold count the better i feel. and have less food,skin problems. last summer was hot and dry best i have felt in 10 years. also found were the mold was hiding in my basement.

i have a history of living in moldy homes. i wonder how many people with these problems live in damp humid places?

mold,yeast and fungus are all in the same family and are very adaptable. so rotating foods and anti-fungles seem to work the best for me. i have also had some luck with DGL but only for a few days at a time it locks my muscles up.

too much histamine does make sence.

Hi all. I have been considering taking some kind of diamine oxidase supplement but it seems like they all have a bunch of fillers in them, I was wondering if anyone has found a brand that doesn't have all of these fillers?

Hi, I'm not sure who else has had success, but I know Taylor answered. After years of unexplainable symptoms and the belief I had an anxiety problem or even asthma, I've joined the ranks. Yes, a gut problem is part of this and makes reactions more severe, but I definitely have a histamine intolerance. Most food intolerances seem to go hand in hand with candida when your system is too run down. Last night, I used the supplement and was able to have a large meal with sour cream, sugar and RED WINE no problem! No sleepiness, stomach pain, sore throat, eye pain, tingling or tightening muscles! But...does anyone know about next day effects? Like pizza and wheat and sugar can make me very sore and groggy next day (probably feeding candida), wine usually had me waking up sore throat and congested. Does the supplement help with lingering effects or only within the first hour or so. I think it willbe a godsend for certain foods, but isn't a answer if you need to pop them like candy or they don't tackle the fatigue, sluggish, soreness, congestion issues. I would like to hear from somebody who has trialled it longer than me! :)

Hello Everyone, I'm new to this site and have been reading all your messages. I recently was diagnosed with Rheumatoid arthritis after rupturing 2 tendons in my hand. Through that process they have discovered that I have a histamine intolerance. I've been seeing a rheumatologist and a nutritionist associated with his office.

In addition to all the RA drugs I'm on, the nutritionist has put me on a low histamine diet to reduce inflammation and swelling. I see most of you have talked about Histame which is quite expensive. I thought you might be interested in what she suggested.

She said to take N-Acetyl Cysteine (NAC): 500mg twice per day with meals. Can increase to 3,000mg in divided doses, as tolerated. I've just found several brands on Drugstore.com and they seem very reasonable in cost.

In addition she said to add Diamine Oxidase (DAO) with higher histamine meals; taking it 20 minutes before the meal.

I'm thinking this protocol may help some of you reduce the high cost of Histame. The two in concert may have a better effect as well.

I'll be trying them all here soon.