Well, this is kind of a kick in the nuts. You may remember my other posts:
Had a heart attack - need suggestions http://paleohacks.com/questions/68443/had-a-heart-attack-need-suggestions#axzz1ljPwKOeh
and Got my VAP test results - now what? http://paleohacks.com/questions/75930/got-my-vap-test-results-now-what#axzz1ljPwKOeh
Well, I just received my 23andme results and as I (and others here) suspected I am Apoe 2/4. So this pretty much explains it all, right? No sleep apnea, infection, leaky gut, Takotsubo cardiomyopathy, or autoimmune disease.
Two weeks ago I had another lipid panel done after a few months of reduced red meat and eggs. Again, massive changes. Here's the results:
TC 139 (was 232) LDL 87 (was 160) HDL 30 (was 34) TGs 111 (was 188). Glucose 96 hsCRP 2.3 (worked out 12 hrs earlier and came down with a stomach virus 2 days later) A1c 5.0
So, anyone have advice on what to do not to piss of my genes again?
The best answer I can give you may not be right for everyone (and I'm honestly not trying to be a smart-alec or be dismissive... truly... this is a real response after years of dealing with similar news myself), but it's made a WORLD of difference to me over the past 6 months. Stop getting tests. Instead, start listening to your body. Every single one of us probably has some genetic anomaly that scientists can prove will make us sick. Heck, I have a genetic anomaly that doctors told me would result in my death within 2 years -- 10 years ago!!!
Let go of the stress. Start moving around for the joy of moving, and living every day for the joy of living. Eat good food, and don't beat yourself up over the occasional treat... just keep it VERY occasional. Listen to your body and feed it when it's hungry, move it when it's feeling sluggish, let it rest when it's tired.
It's my opinion that NOTHING will keep you alive longer than your life-cycle is supposed to be... when it's time for your energy to pass on to a different state, you're going to go, regardless of your apparent state of health. I've come to think, personally, that JOY is the "magic bullet" for good health. When we're happy, we're healthy -- and if getting tests does anything for most people, it makes us worried, not happy... so rather than checking numbers, strive to find a joyful state where what you do to your body makes you feel as good as you possibly can -- then laugh... a LOT... instead of getting bogged down in worrying about what's going to set you off next.
Do you think these results help or hinder?
How are your BP readings now at home?
APo e2 tends to predispose to lower hdls but to me it is hard to tell why the hdls appear mildly suppressed despite the strong work and effort concentrating on diet, lifestyles and stress reduction.
I suspect that some degree of leaky gut and gut dysbiosis exists, which are detracting the immune system (and hdls as these are the sentinels and warriors of the immune system).
The art of reading a lab test:
Being a 2/4 is not that bad. What you should know (if you don't already) is that the APOE2 allele is actually protective against a lot of APOE related diseases (e.g. heart disease, Alzheimer's disease, stroke, etc). Since you are an APOE2/4 heterozygote, this means you have a protective gene and an a high risk gene which essentially cancels each other out. There is one camp that believes the APOE4 allele is dominant, however the evidence is very weak. There is more evidence to support the idea that the APOE alleles work in a co-dominant fashion, thus APOE2/4 is esentially neutral.
So far every intervention has failed to show any imporvement in removing risk from APOE4 carriers, with one exception. Recently a trial from Wash Univ showed that routine exercise actually benefited APOE4 carriers with respect to overall cognition. I have been studying the APOE link with disease for many years and strongly believe that lifestyle is the strongest predictor of modifying risk for APOE4 carriers. What does this mean? It's common sense, no man made drug currently exists that can help you. There is only one pill (the hardest one to swallow for Americans) that can help you. That pill is routine exercise (>30 min/day walk/jog or equivalent), a healthy diet (no fad diets, just a well balanced diet made up of predominantly fruit and vegetables supplemented with free range meat/fish and very little if any man made foods), coping mechanisms for reducing stress, a good night sleep and healthy social network.
Hi I just had a Berkley test done by my own request. I don't eat fatty food, don't smoke, no known history of heart disease in the family. I am 48 year old female. and I asked for the test because I suffer from panic attacks so I figured removing all physical fears would help reduce the stress of my panic induced fears. All my numbers were very good accept my tryglicerides were a bit high 228. The doctor didn't think my number were worthy of any treatment. I have an APOE Genotype 2/4 and I am not exactly sure what that means to me. I know it is not the Average marker, but I really could not grasp what the doctor was saying and how he waived it off with such ease. Please...if anyone could help me understand just what this means to my health and what I should do I would appreciate it.