How many of you have been tested for this condition? Primal Body Primal Mind claims prevalence is 11% of the population but the symptoms are so vague it seems hard to tell who should be tested for it.
Pyroluria leads to two specific nutrient deficiencies: Zinc and B6. In my practice, almost everyone shows up to need supplemental zinc. And the B vitamins generally are your stress supporters; given how crazy most of our lives have become, most people benefit from supplementation. Did they have pyroluria or just a deficiency? If they feel better with moderate supplementation, that's what's important.
If someone came in with serious symptoms of depression and anxiety, testing may make sense. But it's the same idea as doing an elimination diet vs blood testing of allergens: If you feel better eliminating certain foods or adding certain nutrients, do you really need (or want?) a diagnosis?
I tend to take PBPM with an entire salt-lick, not just a grain. Don't get me wrong it's what got me into the Paleosphere and let me make some huge life improvements but they tend to overstate things more than I'm comfortable with.