Does anyone have any experience with, or thoughts on, taking diamine oxidase (DAO) supplements to combat histamine intolerance? I believe 'Histame' is the brand available in the US and UK. I'm thinking of trying these to reduce my reactions to high-histamine foods while I attempt to heal my gut but they're incredibly expensive. I'm also trying to reduce the histamine in my diet but am finding this difficult for various reasons.
Background: I'm male, 28 with a 20+ year history of wacky digestion and other health problems. Been strict, nightshade-free Paeleo since November with moderate improvement in symptoms. Tested negative for Coeliac, Crohns, Colitis, bowel cancer, diabetes and thyroid problems: my colorectal specialist described me as 'a mystery'. Am currently eating very low carb as I swell up like a balloon, belch uncontrollably and lose weight like crazy whenever I eat any carbs (still trying to get tested for SIBO - virtually nowhere in the UK will test for this - argh!).
Anyway, since going VLC I've reduced the bloating and weight loss but have started noticing reactions to foods such as chicken, spinach, salmon, nuts (diarrhoea, itching, flushing, sinus problems, palpitations etc.), hence I'm suspecting an additional histamine intolerance on top of all the other mess. I can't cut much more out of my diet or there will be nothing left (of the diet or of me). It's all driving me nuts. Any help much appreciated!
Update: I decided not to purchase the DAO in the end and started the GAPS diet instead. I felt that the DAO wasn't going to address the root cause of my problems and wasn't worth the expense.
My experience on GAPS has been mixed so far. I took more probiotic tablets in the beginning but I'm gradually replacing these with fermented foods. After slowly introducing the broths and probiotics I'm tolerating amines better than I used to. However, I've had other issues surface (especially skin problems of various kinds). I'm hoping these are 'die-off' and a good sign, but it's too early to tell.
Update 2: Spoke too soon about the amine tolerance! I'm experiencing major amine intolerance symptoms again. I'm drinking a lot more kefir than before which isn't helping, although it's the only thing that's had an impact on my fungal problems and eczema so I'm reluctant to give up drinking it at present. I've caved in and ordered the DAO. I'll report back when I've had chance to try it.
TJ, my n=1 will not be very encouraging, unfortunately, but I have intolerances up the yin-yang so I imagine most probably write me off as an outlier. In any case, I'm certain I have histamine intolerance and did try Histame, or DAO. Disappointingly I felt like I had the flu a few hours later. I tried it again with much trepidation... had the same reaction. I really wish it had worked, as beer, wine, etc. are sorely missed. However, as PaleoGran mentioned, other allergies/intolerances can be at play. That may even be why I reacted poorly to the Histame - I have a problem with amines, along with phenols and other chemicals that are detailed to some extent by the Failsafe diet. I believe Histame's DAO is from dessicated pig kidneys (?) which would likely make it high in amines; this could have caused my flu-like reaction. However, if you can afford to risk it, it's worth a shot. Sounds like some people benefit from this stuff.
Also, if you have a lot of bloating from carbs I'd imagine you might have yeast overgrowth and might want to look into some antifungals. Raw garlic, food-grade hydrogen peroxide, iodine, medium chain triglycerides, probiotics, etc. might help. I have a hunch that histamine intolerance follows gut dysbiosis and yeast overgrowth because these organisms produce histamine, so treating that problem should help ease the allergen load and improve tolerance. I'm still intolerant - even years after getting my system in check - and doubt it will ever go away, but it was MUCH worse when I had unbalanced gut flora.
Has anyone tried TMG, Folate (NOT folic acid it MUST be L-methylfolate-Metafolin) B6, B12, Inositol and Choline? Those are the classic supplement combinations for treating histamine issues. After 11 years of doctor to doctor, test after test, I self diagnosed myself to one of the 30% of the population who have the inabilty to convert Folic acid to the methyl doner needed to break down histamine. Has worked like a charm and was almost instant relief from the first dose! These supplements are a HECK of a lot cheaper than the DAO supplement on Amazon.
Good luck to eveyone!!
I can't find any sources for this via Google, but I wonder if it's possible for the immune system to develop antibodies to DAO... I guess it's possible that you have histamine intolerance because your body can't produce DAO without it being attacked by your immune system, but I can't back that up with any science.
I bought DAOsin (cheaper than Histame, $15/30 capsules on Amazon) last week more as a diagnostic tool to see if I even have histamine intolerance, which is silly I know, but histamine intolerance was near the end of a long list possible causes for my flushing and weird reactions to meals and I was a bit desparate, and none of he other usual supplements (Vit C, Qercetin, B6) seemed to help. I can't really tell if it's working. It's been just as fickle of an experiment as anything else. Sure, I haven't been that symptomatic since taking it, but I've been fine for weeks on end too before histamine intolerance was even in my vocabulary. In any case, I think you might want to investigate a serious gut healing protocol as it seems to be the only path out of a diet that's becoming more and more limited and frustrating.
People have different reaction to DOA, it DOES really help some people and they use it for emergencies or when they travel. Others who are really sensitive react to the fillers in the supplement. Have you considered seeing Dirk Budka? He's an MD who runs a clinic in London that deals with histamine intolerance and other gut/intolerance issues. People with HIT seriously fly across the Atlantic to see this guy. As a side note, he is making a new supplement called HistRelief that is more powerful and contains no fillers. I believe it's coming out in May.
I'd like to add my pennyworth re Histame. I find it helps, but is not the total answer. I can't help feeling if it were cheaper and one could afford to take about 10 capsules a day it would be worth taking. I usually take two, four or even six capsules with an allergy tablet as well, that gives a better result than Histame alone. Not ideal I know, but when one is desperate......
Hello Everyone, I'm new to this site and have been reading all your messages. I recently was diagnosed with Rheumatoid arthritis after rupturing 2 tendons in my hand. Through that process they have discovered that I have a histamine intolerance. I've been seeing a rheumatologist and a nutritionist associated with his office.
In addition to all the RA drugs I'm on, the nutritionist has put me on a low histamine diet to reduce inflammation and swelling. I see most of you have talked about Histame which is quite expensive. I thought you might be interested in what she suggested.
She said to take N-Acetyl Cysteine (NAC): 500mg twice per day with meals. Can increase to 3,000mg in divided doses, as tolerated. I've just found several brands on Drugstore.com and they seem very reasonable in cost.
In addition she said to add Diamine Oxidase (DAO) with higher histamine meals; taking it 20 minutes before the meal.
I'm thinking this protocol may help some of you reduce the high cost of Histame. The two in concert may have a better effect as well.
I'll be trying them all here soon.
ive noticed there was a person above who mentioned a gene responsible for making the DAO enzyme that degrades histamine.we did a 23 and me gene test on some of us and i found that two of my kids have double defects on that gene snp. meaning theyre likely to have histamine issues because theyre lacking enough DAO becuase of the defect. i recently bought a supplement called DAOSin from swanson vitamins that is showing some great progress for my daughter who has POTS (which seems like a histamine issue to begin with which turns into possible mast cell issues and then eventuallly POTS. she cant ever make her body produce that enzyme on its own so taking it and watching her histamine intake seemed the next best thing for us.
Hello, can someone please follow up on use of DAO? Its very frustrating to find that someone is trying something, and then they don't report on their long-term experience. It sends a strong message that the substance/product is a waste of time, but it could also mean that the success was so profound that the person has gone on about their life and forgotten about reporting thier success. We in the trenches have no way to know the difference! Amine intolerance is something that has kept me from paleo. Please help me and others by checking back in about your experience. TY!
Hoping someone with direct experience will reply about DAO (I've already read the Amazon reviews), but to those who've tried, TY. I underwent experimental therapy with live organism helminths in 2010 for an unrelated issue, which improved; around that time I also went paleo, and added many high histamine foods to my diet. I got significantly worse, so under medical advice I eradicated the helminths. No change. I made a dietary connection recently, and I too think gut dysbiosis is at the heart of the issue. Unfortunate that the helminths didn't help the issue, but I may revisit the issue again with another species after I consult with my GI.
Just so you guys know. I tried histame yesterday and i used to fall to the ground in the bathroom after eating any dairy or eggs, couldnt have gluten either but it wasnt as bad. Let's just say today I ate a pizza a burger and chocolate and eggs for breakfast. It sucks that ppl aren't saying histame works but it is a god send for me. Give it a shot. I feel like i can live again, it was worth spending the money to experiment on it. I had lost almost all hope and this was my last go at it. Thank god I tried it.
Histamine diet? 2 Answers
Histamine intolerance - what do you eat? 20 Answers