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I came across this article in the newspaper a few days ago about the dangers of excess beta-carotene.

http://www.biosciencetechnology.com/News/2012/05/Potential--Dark-Side--Found-for-Diets-High-in-Beta-carotene/

I eat large amounts sweet potatoes and carrots to full my exercise, should I be concerned?

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what's your definition of "large amounts"? How much do you normally eat a day/week? – Sunny Beaches May 5 2012 at 17:38
This is not new. Those dangers of beta-carotene have been suspected for a long time, see atbcstudy.cancer.gov/pdfs/atbc33010291994.pdf – Poisson May 5 2012 at 18:00
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I think this might be the study: jbc.org/content/early/2012/03/14/… – April S. May 6 2012 at 2:15
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That's it, April S. They basically took beta-carotene and broke it down into it's smaller parts (most which had to be synthesized) and then tested those parts against human cells to see what would happen. All in isolation. – HeatherN1321 May 6 2012 at 15:43
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Seems like a very hasty reaction to a very small bit of science. Way too early to say anything really! – Matt May 6 2012 at 22:13
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13 Answers

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Good timing on the study.

I was just eating a ton of carrots and sweet potatoes the last few months. I am now slowing down, stopping carrots completely.

Ran into skin problems, but they might have been due to other things like stress.

I am now decreasing my beta carotene consumption and increasing my retinol consumption.

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I remember reading somewhere this might be due to B12 deficiency and that B12 was indeed recommended so that beta-carotene is used in a good way.

So the question is, if you do have adequate amount of B12 (dairy has plenty), is it ok to consume beta-carotene (carrots and sweet potatoes)?

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Another wrinkle: You don't absorb much carotene from raw carrots. It has to be cooked first ... – rammer May 5 2012 at 18:32
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You need fat to absorb beta-carotene as well. When I roast my carrots the oil turns bright orange, I know I'm solubilzing the beta-carotene that way. – Matt May 6 2012 at 22:10
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Looks like I have to look for another source of carbs. I was consuming 3-4 pounds of sweet potatoes daily as well as carrots and a lot of leafy greens. This just goes to show the superiority of animal products.

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To give you ideas, my sources of carbs are oranges, apples, bananas, and peaches. – Anon May 30 at 17:56
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I thought beta-carotene was what your body converted into vitamin A and that it only converts as much as it needs?

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Beta carotene is not efficiently converted in general. Genetics can also reduce that efficiency further - there are known genes that influence efficiency. – wildwabbit May 5 2012 at 20:38
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Ask yourself why people here keep recommending liver and fish oil (which have vitamin A with no conversion needed). – Poisson May 5 2012 at 21:18
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The question this raised for me, is if these caratenoids have anti-A activity.. perhaps the negative effect observed is from people with already minimal vitamin A (retinol) in their diet getting even worse activity.

I consume alot of carotene from sweet potato and pumpkin (~1kg a day) and this has been a good reminder to diversify my starch sources. My retinol status is quite good though (alot of liver in particular) and with some hope outweighed the negative effect on vitamin A produced by the caratenoids.

My first course of action is less sweet potato and more pumpkin.. while I look for some whiter starches (or purple :D ).

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paleomouth, have you found decent substitutes? I miss my kabocha and sweet potatoes. – Domtx008 May 30 at 16:53
also, i am pretty sure that the purple japanese yams also have high levels of beta carotene unfortunately... – Domtx008 May 30 at 16:54
I am surprised at this and am trying to find more evidence. Seems unlikely that something with white or purple flesh would have significant caratenoids – PaleoMouth Jun 8 at 13:30
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I'm going to have to look into this more, try to find what studies they're basing their conclusions on. It was my understanding that the cancer-causing beta-carotene was the one found in vitamins, NOT whole foods. This paragraph from the article seems to support my recollection: "The findings also might explain why, in a decades-old clinical trial, more people who were heavily *supplemented* with beta-carotene ended up with lung cancer than did research participants who took no beta-carotene at all. The trial was ended early because of that unexpected outcome."

In fact, the researchers aren't really talking about the effects of beta-carotene in whole foods. And it appears the whole purpose of their study is to understand why the artificial beta-carotene in the test on male smokers and asbestos workers created a higher incidence of lung cancer. So they can genetically engineer crops with increased beta-carotene for populations who are lacking vitamin A in their diets.

What I take away from this article is that the beta-carotene in our carrots and sweet potatoes is in no way the same as the beta-carotene used in the study that caused an increase in lung cancer. There is a danger when we isolate vitamins and minerals from the whole foods they came from because, as the researchers themselves stated, we don't fully understand how all the properties in a whole food work together to make it nourishing.

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my understanding from it is that beta-carotene is beta-carotene whether supplemental or in a sweet potato... it is how our body processes it which is problematic - it gets enzymaticly cleaved into a product which antagonises real vitamin A in our body. He poses that this is the chemical that is problematic. – PaleoMouth May 6 2012 at 5:30
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+1 Whole foods and processed refined foods are totally different. Folks need to stop panicing over stuff like this. – Matt May 6 2012 at 14:56
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Yeah compounds in isolation are somehow magically different than when they come in the form of little orange sticks in the ground. – Kasra May 30 at 18:35
Yes, i tend to agree that isolated supplements are not the same as whole foods. However, see my reaction below and I've also heard of anecdotal accounts of beta carotene affecting night vision. Nothing damaging or serious but it seems to confirm that Vit A might be blocked by taking in excess Beta Carotene. – Mambo May 31 at 0:36
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Could someone let us know which supplements contain beta-carotine? Thanks so much.

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It should say Vitamin A (As Beta-Carotene). If it says from fish oil or something, it's retinol. It usually says. – Chris May 6 2012 at 19:57
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I would have assumed that artificial supplementation was the only way to take in harmful amounts, but the amounts of carrot/sweet potato mentioned above make me wonder.

Polar bear and beaver liver are not eaten because their vitamin a content is so hight as to be potentially lethal.

Check the nutritional info on the vegetables in question, perhaps here: http://ndb.nal.usda.gov/ and adjust your consumption accordingly.

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Those animals' livers are toxic because they have massive amounts of retinol, one of the active forms of Vitamin A. As has been mentioned here beta-carotene is converted extremely inefficiently to retinol forms, so it is not acutely toxic. The original paper is talking about potentially subtler problems with beta-carotene: totally different from acute hypervitaminosis A that can result from too much retinol consumption. – Ingenol May 6 2012 at 20:10
I think john's point was that natural supplementation from whole foods can still be problematic – Domtx008 May 30 at 16:58
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here's a comment i found under another article on the same research http://www.nutraingredients.com/Research/Researchers-reveal-dark-side-to-high-beta-carotene-intake

The "shockwaves" referred to over a dated trial which used synthetic beta-carotene on already sick people (smokers) simply illustrate that old myths die hard. There is no evidence that the intake of natural mixed carotenes is in any way harmful.

And as for the current supposedly negative findings (if verified) would it not be a more reasonable view that such molecules are simply a self-limiting factor placed in foods by a wise Creator? In this way a possible oversupply of Vitamin A in the body is prevented. It explains the well-known fact that a high intake of natural mixed carotenes results only in health benefits. Because the above seems self-evident, one needs to ask the following question.

Is this report (as presented) just another attempt by vested interests to tarnish everything natural and to promote their own agenda?

Comment by Edward Jackson

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Can we just all agree that anything in excess is bad? K thnx.

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so very true. in addition to my comment about the aesthetic downside of too many kabocha pumpkins, I recently learned that these pumpkins absorb more toxins from the soil, so much so that some farmers specifically plant them in order to get rid of those toxins from the soil!! this really convicted me that you really cannot do anything to excess, you just never really know all the hidden dangers... – Domtx008 May 30 at 16:48
No, the point is isolated nutrients made by man that's supplemented in without fully understanding their interactions with other chemicals. – Mambo May 30 at 21:39
Especially if it's something that's extracted and provided in huge amounts, or synthesized which makes it slightly different than what's found in nature. The same way that synthetic B6, B12, E are not good for us while their natural versions are. – raydawg May 31 at 10:42
The problem with this answer is that it isn't an answer. It's like saying "just eat everything in moderation". – Korion Jun 4 at 17:15
I agree with April. Too much of anything will kill you. That's what "too much" means. – borofergie Jan 2 at 16:13
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sad. I overdid kabocha pumpkins over the winter (a whole 2 pound pumpkin daily) and by spring everyone thought i had been spray tanning over the winter. i stopped the pumpkin for aesthetic reasons because unfortunately the shade looked like the spray tan gone bad. I really really miss my kabocha but now it appears i have more than an aesthetic reason to keep them at a distance. can never stop at just a little unfortunately.

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Interesting. I wonder now then what I experienced was accidental. For about 2 months, I was on a yam-heavy safe starch diet. I consumed probably 400g+ of orange yams daily during that span (about 3 medium-sized orange American Southern yams).

I noticed my vision becoming very cloudy and blurry at night. I also occasionally (once or twice a week) take 2 tsps os Carlson's Cold Liver Oil, which has 850 IU of Vitamin A per teaspoon. When I did, I noticed my vision clearing up almost immediately. I also noted my sudden craving for the CLO (LOL) like an iron-deficient person craving ice.

Could this be that the excessive consumption of orange yams had anti-Vitamin A properties, resulting in paradoxical Vit A deficiency? The result is paradoxical, just like the linked article points out, because the beta carotene doesn't always convert to Vit A as assumed but blocks Vit A.

(But then do we really have to wonder? Taking calcium actually increases cardiovascular risk. Taking resveratrol in supplement form doesn't seem to lengthen longevity. Large intakes of fish oil could increase the risk of cancer.)

But the crux here is that this occurred when I was eating yams high in beta carotene, not any supplements. If so, this is very alarming indeed! In the above cases where vitamins had unintended effects, they were in the form of isolated nutrients.

Anyone on a high safe starch, orange yam diet experience vision anomalies like I did? If so, then, try taking some cod liver oil and see if the anomaly clears up. My tale seems to confirm the article's findings. Indeed, the beta carotene's anti-Vitamin A effect doesn't seem to be just limited to supplements. Confusing, huh? Before, we thought Beta Carotene was good for vision; now we're told, only up to a certain amount. But how do you know you've reached the tipping point? I was only trying to replicate the Kitavan diet in my experiment.

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Thats very interesting. Do you eat eggs and liver? – Kate Jan 2 at 14:27
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What does these all mean!!! Shall I take Anti oxidant pills with Beta Carotene or not!!!!

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