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The recommended supplemental dosage of PQQ is 10-20 mg a day.

You would have to eat 350-700 pounds of natto a day to reach that level of PQQ intake. (Source.)

How is such radically unnatural intake of this vitamin justifiable?

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2 Answers

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According to research done by the Institute of Common Sense, it was discovered that in 99.9% of cases, excess is bad.

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Lots of unnatural things are justifiable.

The more obvious example is in those missing something in their bodies. Supplemental thyroid hormone for those with thyroid dysfunction, supplemental insulin for type 1 diabetics.

In the PQQ case, if the goal is to achieve health benefits from supraphysiological doses, than the ends would justify the means. Of course the rub is that there isn't a ton of long-term evidence for unnatural dosages of PQQ, resveratrol, and friends. Personally, I tend towards the precautionary principle. People have been proven wrong throughout history when they mess around with large amounts of stuff. I don't feel confident in my ability to jump from selective research findings to guessing how my body will handle things over large periods of time.

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