Came across this article today discussing how the popular diabetes drug metformin puts the brakes on cancer.
Of course, the question I then ask myself is HOW is that so? I suspect because it basically creates an "internal hormonal milieu" similar to what one sees on a reduced carb diet.
Even the the article itself suggests as much. A quote from the article...
"...says researcher Anthony M. Joshua, MBBS, PhD, a staff medical oncologist at Princess Margaret Hospital/University Health Network in Toronto. But a growing body of evidence -- from lab, animal, and human studies -- suggests metformin mounts a multi-pronged attack against cancer, he tells WebMD. It lowers levels of insulin in the blood, and insulin contributes to the growth of cancer cells, Joshua says."
One of the cool things about Metformin is that it activates AMPK (AMP-activated protein kinase) pathway. Exercise also does this.
If you take a look at this graphic representation of the AMPK pathway, you can see the significant regulatory role that it plays in energy metabolism.
Activating the AMPK pathway serves to combat cancer on multiple fronts including P53, mTOR, etc...
Metformin is a fascinating drug. One of very few where I believe the benefits FAR outweigh any possible risks (which tend to be rare and include Vitamin B12 deficiency and lactic acidosis).
Metformin, like common aspirin, is one of those drugs that keeps on giving and reveals little in how it does it. There is a wonderful article in the Jan 2012 issue of American Scientific that links Metformin to anti-aging as it mimics many of the things that cells do to stay vigor and prevent its dying off. Metformin is of course is generic and often falls into the starter drug doctors give new patients , to be replace by the new bigPham drug that does more damage than good or to full blown insulin injections which many Diabetes don’t need. I still that a little Metformin even though my diet is perfect- it’s a great drug and I can’t believe I just wrote those words.
It is a partial activator of the Ancient Pathway I have written about in CT-6 in all mammals. Brandon's point is spot on. Plus one to you Brandon!
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