Was wondering what the survival advantage could have been and came across this paper:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917125/?tool=pubmed (full free text)
From the abstract:
"All humans are double knockouts. Humans lack the ability to synthesize vitamin C due to a mutation in L-gulono-lactone oxidase that occurred during the late Eocene, and humans have higher serum uric acid levels due to a mutation in uricase that occurred in the mid Miocene. In this paper we review the hypothesis that these mutations have in common the induction of oxidative stress that may have had prosurvival effects to enhance the effects of fructose to increase fat stores."
What do you think?