This is what I could find on the ALCAT method of allergy testing. There is very little published on the subject. Most of the references given by the company appear to be unpublished or presentations given at conferences, which makes me a little dubious. Selling people tests is often a good way to make money.
Unproven techniques in allergy diagnosis (2005).
In summary, the ALCAT test system
represents a new edition of some old
claims of “cytotoxic testing”, claims
which up to now have not proven to be
scientifically established. The ALCAT
test system is for the time being
relying on unproven statements that
lack scientific and clinical proofs of
Controversial aspects of adverse reactions to food (1999).
All kinds of unproven techniques and
tests are abundant in the alternative
medicine market, and usually these
totally escape of®cial control. Only
rarely are results on these tests
published in papers covered by the
standard databases. In the
cytotoxicity test, a food allergen is
added to whole blood or to leukocyte
suspensions. The reduction in number
or the change in appearance of the
cells would indicate a sensitivity to
a speci®c food (171±173). However,
controlled studies (174±176) have not
shown any ef®cacy of the test in
diagnosing food allergy or
intolerance. In contrast, several
studies demonstrated that this test
cannot distinguish between offending
and tolerated foods and between active
treatment and placebo (176, 177).
Moreover, test results were not
reproducible when repeated several
times on the same patient with the
same food allergen.
A test for non-IgE-mediated food
hypersensitivity (ALCAT TM) has been
launched; it measures changes in
whitecell diameter after challenge
with foods in vitro. The procedure is
not documented, as only a few relevant
papers are listed in the databases.
Most of these discourage the use of
the test due to lack of
reproducibility, whereas the other
reports do not ful®l the inclusion
criteria mentioned earlier (178).
Therefore, more investigations need to
be published. Since many trials with a
negative outcome are never published,
the risk of a tendency to overestimate
the eficacy of the test should be
borne in mind.
Inappropriate test methods in allergy (2010).
Successful internet marketing,
infiltration of academic programs and
superficial reporting by the media
promote the popularity of unqualified
diagnostic tests; also in allergy.
Therefore, critical observation and
quick analysis of and clear comments
to unqualified methods by the
scientific medical societies are more
important than ever.