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GMO tomatoe link Please read. Looking forward to the responses.

Don't worry about it being a nightshade, for the purposes of my question just imaginge its spinach, or broccolli or something you'd eat without worry.

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9 Answers

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GMO isn't scary by itself. Lots of people are trying to make GMO be a scary thing: from the envrionuts who go around dressed in HASMAT suits protesting all the way to reasonable bloggers. This is yet another area where context matters: why is something GMO, what makes it better/worse in this case!

For example GM wheat. why: it grows faster, stands up better, more yield per harvest. how: the extra genes in the wheat encode for more gluten which is a structural protein (and other proteins). So GM wheat has more gluten than wheat of yore, plus it has other proteins in it that may or may not be bad for us, we don't know. The problem is that because it's still called "wheat", it's still treated as "wheat" by the USDA and food labeling laws, but it actually is a different organism.

Another example GM corn. why: it's resistant to Round-up (and other glycophospate herbicides). what makes this bad: well now you can just dump herbicides on your crops and kill the weeds. Just because the corn now doesn't die, doesn't mean that herbicides aren't in the food. Or that you're poisoning the water supply by such overuse of herbicides, etc.

In both of those cases the GM component does something bad and often unintended. But that doesn't mean in general anything GM is bad. Nature does it's on GM with cross pollination and the like. You need to look at the output in each case and see if the GM did something bad.

The main point, is don't be like the environuts out there and make tons of noise about a something because it sounds scary. Make sure you understand it. If it truly is scary, then make noise.

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I pretty much completely agree. This is a "dredge" of sorts to feel out the community and the thought process that goes on. I see a large amount of so-called informative posts out here that are irreverent of fact and science. This is a problem when the metaphorical torch the paleo community holds above others is the proper application of logic to the available evidence. – cbucker Nov 6 at 20:02
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I worry about GMOs because the motives behind their production are based on profits rather than productive health. As others have said, I'm not against trying a new food source if it has been extensively researched. What does concern me is that $45 million has been spent in opposition of the labeling.

Matt
PhysiqueRescue.com

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Labeling should exist so I know what I'm purchasing. I'm not interested in consuming GMO products as there is no data showing they are safe long-term. Monsanto won't allow it, as they hold the patents. – MathGirl72 Nov 6 at 19:53
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^ I always thought the burden of proof would lie with the newly purposed food source. And you know what they say about assumptions. The US is just far behind other countries in many ways. Labeling is one of them. – JayJay Nov 6 at 22:35
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I agree that GMO-critics need to show more evidence that supports their position. The absence of studies on GMOs does not mean they are unsafe, but rather unstudied. The recent study however showing significant cancer rate enhancement in mice fed Roundup corn over their lifetimes is something to consider. – Matt Nov 7 at 0:23
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@cbucker could you bother to link the actual studies? I don't like to get my science second hand through hand picked articles. That goes for the original question too. I was looking for the roundup study. They did have a group with only the GM and no round up, so the info is there somewhere. – JayJay Nov 7 at 2:18
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Assumptions aren't inherently bad, as you seem to (wrongly) assume. Inductive arguments depends on assumptions. For someone who's seemingly keen on science and logic and 'shooting down' others, I'd expected you to recognise that. – Michael Nov 7 at 3:26
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I'm not blanketly against GMO. Each new product needs to be judged on a case-by-case basis. I am, however, skeptical of a new GMO product, so it needs to be scrutinized properly.

So to answer the question, yes I would eat a GMO product if it's thoroughly proven to be an improvement over it's natural counterpart.

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Yikes! No, I wouldn't touch that tomato with a ten foot pole.

"Researchers genetically engineered the tomatoes to produce 6F, a small peptide that mimics the action of ApoA-1, the chief protein in high density lipoprotein (HDL or "good" cholesterol). They fed the tomatoes to mice that lack the ability to remove low density lipoprotein (LDL or "bad" cholesterol) from their blood and readily develop inflammation and atherosclerosis when consuming a high-fat diet."

Are we also to assume that this study was done on humans that were genetically modified to lack the ability to remove LDL and readily develop inflammation and atherosclerosis? If so I don't see the relevance for a population at large anyhow.....moving on though.....

This is a scary proposition. To artificially/genetically alter peptides to affect cholesterol (or to act as for a response). So now, not only are we afraid of fat and cholesterol, but we are making GM foods to alter our bodies levels and responses to such. So statins in the water supply may actually come to fruition I suppose.

We also have to point out that your link does not actually show an improvement in health or longevity for the rats in question. Kinda like all the cholesterol hype. Bunch of markers that we assumed were associated with better health turn out to only be loosely correlated with one type of death while actually increasing the likelihood of overall mortality.

Fact is you can ASSume this is safe if you like, but our track record with ASSumptions kinda sucks.

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I think the question you meant to pose was...."If we could make GM tomatoes that allowed you to live to 120 without disease or infirmary would you eat it? If so how do you reconcile that with your word views?" – JayJay Nov 6 at 23:35
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From you I shall take that as a compliment. – JayJay Nov 7 at 1:02
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As I stated above...and so I can track it here...we need more studies. How hard is that to understand? – JayJay Nov 7 at 1:15
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Excellent points, JayJay. The way I see it this as essentially a very preliminary drug study using tomatoes as a delivery vehicle. – Mscott Nov 7 at 3:53
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Ok cbucker, you win and are completely logical in your views in your own mind. In my analysis however you are highly irrational, and don't comprehend enough in terms of physiology or the workings of clinical scientific exploration and application to even be involved in this sort of discussion. Good luck with the philosophy bit. – JayJay Nov 10 at 1:18
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The paper doesn't appear to be available, but the way they are talking it doesn't sound like they used a control group. Tomatoes inherently have some beneficial properties and have improved cardiovascular health in mice before:

http://www.ncbi.nlm.nih.gov/pubmed/22224814 http://www.ncbi.nlm.nih.gov/pubmed/17872457 http://www.ncbi.nlm.nih.gov/pubmed/10052125

Including ApoE-deficient mice who are susceptible to atherosclerosis.

If you want to say that new spiffy GMO tomatoes are da best tomatoes you have to compare them to regular tomatoes under the same conditions, because regular tomatoes improve cardiovascular health. The new changes could change nothing.

Chris Masterjohn has written an article about the reverse cholesterol transport theory (HDL tha good cholesterol saves our arteries from cholesterol) and how it is a little more dubious than people think. He mentions an HDL-boosting drug that failed miserably to prevent heart disease...and killed a lot of people http://blog.cholesterol-and-health.com/2009/03/wherefore-art-thy-protection-o-hdl.html It may not be the same thing, but I am scared of these tomatoes. Luckily they would probably be labeled as super-tomatoes.

And those mice are an even worse extrapolation to humans than regular mice, why not just use normal mice if your tomatoes are beneficial under normal conditions? The mind boggles. Even if this product is safe, it wreaks of snake oil.

http://4.bp.blogspot.com/-1N3oqbmSiMk/TgtAd0-HLoI/AAAAAAAAIH8/ZpktSCnzFck/s1600/Tom.jpg ???????????????

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I said it plainly, there needs to be a regular tomato control group, as well as a no-tomato control group, so that we can say that the GMO tomatoes are better than regular tomatoes, which do all of those things in their own right. There is no way to say that the new modification helped the already beneficial properties of tomatoes. And there is no rationale for using GMO mice because you can produce all of those changes with a bad diet in mice. But you aren't introducing profound genetic changes in mice that no human has. – Stabby Nov 7 at 21:41
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3 groups needed. 1 no-tomato, 1 regular tomato, 1 gmo tomato, that's your take-away. That the scientists didn't do this screams snake oil. – Stabby Nov 7 at 21:42
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All I want is for them to try to prove that their magic tomato is better than a regular tomato by comparing them, how is that an issue? That they don't demonstrates obvious bias. "They fed the tomatoes to mice that lack the ability to remove low density lipoprotein (LDL or "bad" cholesterol) from their blood and readily develop inflammation and atherosclerosis when consuming a high-fat diet." ALL HUMANS CAN REMOVE LDL FROM THEIR BLOOD, THIS IS THE GENETIC CHANGE. I never said that no GMO tomato could be beneficial, just that I want them to prove that it's the modification and not the fact... – Stabby Nov 8 at 10:19
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that it is a tomato. I provided links demonstrating that regular tomatoes improve the exact same clinical endpoint: atherosclerosis. It is obvious that tomatoes reduce inflammation: another endpoint ncbi.nlm.nih.gov/pubmed/23069270 The other markers are not endpoints. show me that GMO tomatoes improve clinical endpoints better than regular tomatoes in mice that can remove LDL from their blood like humans can. That is all, good day sir. – Stabby Nov 8 at 10:22
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"Worst case scenario" not being able to clear LDL from your blood is not a human scenario at all. And the rest of what you say is just assertion, there is no way to demonstrate that the GMO tomato actually improves health more than a regular one unless you compare them. Asserting that the differences will extend lifespan and reduce disease more than the regular tomato is begging the question, as this is the first attempt to test the new "drug" and there was no regular control. I just put horse piss in a whey shake and fed it to mice, which increased their lean mass, that must mean that... – Stabby Nov 9 at 0:30
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I don't think I would eat it. At the very least I would not eat it till more time had passed and more testing was done but even then I don't know. I don't need to eat that kind of food. My cholesterol is great as is so why would I mess with what my body is already doing? If it's not broke don't fix it.

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And your comment is asinine, cbucker. Don't ask for input and the opinions of others if you aren't open to other views. – MathGirl72 Nov 6 at 19:18
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I don't find anything dogmatic in demanding long term testing for efficacy before unleashing a previously unknown on the entire population. And in the evidence department heirloom tomatoes have a lengthy track record. Since you do have a choice, what is wrong with choosing the one with more evidence of safe consumption? – JayJay Nov 6 at 23:20
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Its fine that you can't prove a null hypothesis, but that doesn't mean you don't even perform the studies necessary to disprove it. And those take time and much more information than is in this single experiment. – JayJay Nov 7 at 1:13
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Matt said "The absence of studies does not mean that they are unsafe, but rather unstudied".....well I have a problem with that. I want more studies. – JayJay Nov 7 at 1:14
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As is anything you disagree with apparently. – JayJay Nov 10 at 5:43
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Since there's scant evidence from methodologically-sound, clinical studies that elevating HDL is a cause of reduced heart disease, I wouldn't seek these tomatoes out.

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Did you completely ignore the inflamatory markers and anti-oxidant enzymes, or did you just not bother to read the article before sharing? – cbucker Nov 6 at 18:40
@cbucker, why not get antioxidants from food? Why not get HDL from good quality fats such as grassfed butter. Why does anyone need to get it from GMOs? – raydawg Nov 7 at 21:25
This is food ray, and why do you keep saying 'get HDL' and talking about cholesterol and the like? I never said there was a 'need' to get anything from a GMO. – cbucker Nov 7 at 23:28
Is it food? It has been described as drug by the author? I would describe it as drug with a food delivery device....that is if I was forced to describe this VERY preliminary trial. – JayJay Nov 10 at 5:45
playing semantics, equivocation, petty nit picking, negative image words, irrelevance, diversion. The stage if the trial is irrelevant in the context of this question. – cbucker Nov 10 at 17:48
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I absolutely don't trust GMO products and want them labeled, and will avoid them like the plague. The industry has consistently claimed to be improving our lives, yet their goals has been to own patent rights and to produce a system of farmer slavery.

Further, while they've claimed to create or that they plan to create more beneficial products, in the end, it's about making more profits. GMO salmon has an increased level of growth hormone which we don't know the effects of on humans.

BT Corn produces its own toxins to kill of insects. We don't know the effects on humans long term.

Roundup Ready plants are drenched in far more glycophosphates than conventionally grown plants. This stuff is known as an endocrine disruptor. Who knows what other effects the plants have on humans even without the extra pesticides.

These products are an unnecessary health risk whose only benefit is to enrich the companies that produce them. Thanks, but no. I've probably eaten the stuff without knowing it, and I don't know what harm it did. I seek out organic produce whenever possible, not just because organic is lots better than conventional, but because it avoids GMOs.

The FDA is useless and owned by these interests - they don't require much testing of these items and only the say so of the manufacturer. The studies that they do are very short and are on mice, a lot of the results are hidden from the public and the studies repeated until they get the results they want. There's no oversight, there's no open review.

It's one sided and the side that wins isn't the consumer of these products, it's the manufacturer. I would not risk my health, nor that of my kids and their future kids on any of this garbage any more than I'd go out and consume wheat, corn, or soy.

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So, you're saying you wouldn't eat the tomato if the benefits translated perfectly to humans? You wrote a bunch, but none of it really had any relevant substance so excuse me if I'm being dense. – cbucker Nov 7 at 16:55
Why would you eat it? As far as I understand this peptide does what cholesterol does. Why not just raise your HDL levels by eating a good grassfed butter? Why do you (or I) need to eat dangerous GMOs in order to gain this dubious benefit? Unless you're just trolling or working for big pharma/agra. – raydawg Nov 7 at 21:21
There are so many things wrong with your response I'm not entirely sure where to start. First: the peptide isn't in any way shape or form acting like cholesterol. Second: Why is it dangerous? Third: what makes the benefit 'dubious'? fourth: because I disagree with you does not mean I'm trolling and/or working for big anyone, it's called a question-begging definition. – cbucker Nov 7 at 23:19
Yes, I'm saying I would avoid any GMOs, including that tomato. I didn't say the peptide did exactly what cholesterol is, I said, if I wanted to raise my HDL, I'd eat more healthy fats. I don't know if the peptide has harmful side effects or not, and since GMO plants aren't an exact science, but rather a shotgun gene insertion, I absolutely would not eat that tomato. If the peptide itself did something beneficial and was well studied for many years, IF, and only IF I needed it and couldn't get its effects elsewhere, I'd take a purified form of whatever it was, not the whole plant. – raydawg Nov 8 at 16:06
I don't believe you've read the article, it clearly states that the peptide does provide some of the same benefits as HDL. I don't know that it isn't dangerous, I don't need to have proof that it is dangerous. The manufacturer has a duty to prove its safety, and I don't mean the rubberstamping style that GMO makers use now. I mean multi year studies, not just with mice. The benefit is dubious because I can get the same kinds of effects by eating more grassfed butter. I don't know why you're pushing this stuff when it's unnecessary. Hence, I distrust your motives. – raydawg Nov 8 at 16:09
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I avoid GMO like the plaque. And for anyone out there that has any IBS or gut issues: http://www.askdrgonzalez.com/gmo-foods-cause-bowel-inflammation/

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The following links should be all that is necessary to change your mind. academicsreview.org/reviewed-individuals/… doccamiryan.wordpress.com/2010/12/11/… (just for leisure reading) rationalwiki.org/wiki/NaturalNews en.wikipedia.org/wiki/Ulcerative_colitis (no mention of GMO) en.wikipedia.org/wiki/… (no mention of GMO) forbes.com/sites/henrymiller/2012/09/25/… – cbucker Nov 19 at 15:35
academicsreview.org/2012/10/… (just another one, to boot) – cbucker Nov 19 at 15:37
quackwatch.org/search/… rationalwiki.org/wiki/Mehmet_Oz – cbucker Nov 19 at 15:42
TY cbucker-- but I am still avoiding like the plaque. THis is just a n=1 --since I started avoiding I can not tell you how much better I feel. And no it is not just from giving up grains -- i eat grains but non-gmo. Joints feel better stomach feels better etc. Sorry but I am a beliver that frankenGMOs are bad. – TrynAgain Nov 20 at 12:25
A true believer my friend. – cbucker Nov 21 at 2:30

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