I'm a physical therapist. So, movement: check!, social interaction: check!, variation: check! So no reasons to complain here! My wife (also PT) and I work at home, so no commuting, only bringing the kids to school by bike, that's nice too. And not too much computer work. If I'm doing too much computer work, it is my own damn fault (or the fault of paleo websites).
Things that could be better: 4 days in the week are working until 9:30pm. On the other hand, we compensate that by getting some leisure time in the daytime, which is nice for walking and working out.
The thing that could make my job even better is if I could work outside. I'm thinking about that. I would like to give some outdoor classes of natural movement (à la MovNat) for kids, or for adults. I already teach a lot of my patients to run barefoot/minimalist.
Although I really like my job, the one thing I can imagine getting bored of, or better, getting frustrated with, is that so much of the problems I see are perfectly preventable. Secondary prevention (preventing a problem from happening again, after the patients get better) is something I work on a lot. And yes, it is evolutionary based!
By the way, I really agree with Brad: I've always valued time more than money (he put that nicely, maybe that's why he is a writer).
That would be my paleo-work and lifestyle advice (besides the food/exercise/...): Make time to do what makes you happy. Because time = money <=> money = time. Use your money to buy time to do what you like and what really makes you happy.
For us that is, family and friends-time, preferably outdoors, walking and hiking, some vigorous physical activity now and then, play, relaxing, eating. Luckily not expensive things. Well, maybe that's not a coincidence: things that make jumans happy are not for sale.
Nice question Kamal.