Ah yes. The conventional wisdom that aspirin thins the blood and therefore makes it more difficult for plaque to build up in the arteries....which therefore decreases the amount of strokes. Or taking aspirin reduces the possibility of a recurrence of a cardiac event or stroke.
If you just change your diet to a truly paleo diet, plaque build up will not occur. And you avoid any internal bleeding in the brain and gut that is reported among the population of aspirin takers. True, the incidence is small, but do you want to take the chance? http://njms2.umdnj.edu/hwmedweb/archives/AspirinBleeding_archive.htm
Just google "aspirin internal bleeding" for more data on aspirin & bleeding.
Aspirin is a pretty amazing substance. But, I think it's likely redundant with eating a low linoleic acid diet and getting adequate omega 3s. I also think eating right in the first place is superior - aspirin is the band-aid; eating right is the cure.
Based on the evidence there is, I think it makes a LOT of sense to a take a low-dose aspirin unless you are already on (and have been for at least a few months) a strict low linoleic acid diet, ensuring also adequate intake of omega 3s.
Regular intake of aspirin has been linked to digestive problems, including gastrointestinal bleeding.
Improved digestion by healing your GI track is accomplished by removing gut irritants from the diet, things like grains and legumes. Looks like regular ingestion of aspirin could cause similar problems.
Recommendations like aspirin are band-aid remedies geared toward the general public who is assumed to be eating the SAD. If you eat paleo there's no need for it. Personally I want my blood to clot when I bleed.
As far as observational studies go, unless confounding variables are removed, they are largely worthless. When I see a study of the effect of a substance done on paleo eaters I'll take notice. I'm not holding my breath.
Chronic use in adults will produce stomach bleeding for sure and deplete your vitamin C
Its better to just use fish oil. If you have to take it, use vitamin C during the day to prevent bleeding.
Vitamin C has been shown to reduce gastric mucosal damage and gastric toxicity induced by ASA-generated reactive oxygen metabolites [55, 56]. After ingestion, both aspirin and salsalate are rapidly converted ro salicylic acid. Aspirin and salicylic acid can increase urinary excretion of vitamin C, lower leukocyte ascorbic acid levels (by 50%), and decrease its metabolic availability [57 - 60]. The gastric mucosa is the largest depot of ascorbic acid in human body, with ascorbic acid concentrations 25 times higher than in plasma . Some data suggest that aspirin may protect endothelial cells from oxidant damage via the nitric oxide (NO) cyclic guanosine monophosphate (cGMP) path way [62,63]. However, gastric epithelial cells require vitamin C to translate inducible heme oxygenase (HO-1) miRNA "into active protein, which then may exert gastroprotection by its antioxidant and vasodilative propertie... Induction of HO-1 is considered to be an adaptive cellular mechanism in response to oxidative stress" . Thus, a significant body of data shows that the oxidative damage caused by aspirin can induce exfoliation of gastric epithelial cells, formation of gastric erosions, and GI hemorrhage. In particular, the gastric mucosa of individuals deficient in vitamin C (and possibly other, synergistic nutrients) might be less able to increase the rate of cell production and therefore susceptible to increased bleeding after aspirin ingestion. Vitamins A, E, and C and bioflavonoids may enhance the "antiaggregative effect of aspirin, prolongate its activity, [and] increase hypocoaguloemia due to reduced releasing of thrombocyte factors 3 and 4 into plasma