Paleo Diet and Paleolithic Diet Questions & Answers

Question

2

I've done an adrenal fatigue salivary test. And my results have shown some issues with Cortisol and melatonin. However, the biggest problem was salivary Estradiol and Progesterone which were way above recommended levels (8.1 PG/ml, 213 PG/ml).

I have tried looking for an answer online, but I haven't found anything useful so far. Any clues as to what the cause of this could be? And what to do about it?

I've been strict paleo for 2 years now, lean and fit. I decided to do the adrenal stress test since I've been having issues with managing my stress lately. This, I believe, has led me to gain abdominal fat, decrease my sleep quality (I wake up tired), and decrease my overall energy and mood levels.

flag	asked Apr 2 2011 at 18:06 Dave 283●3●10

	Ever take steroids, or anything for hair loss? – TheOriginalKaz Apr 2 2011 at 21:10
	Nope, I'm 22 yr old – Dave Apr 3 2011 at 14:31

The Quilt · Accepted Answer · 2011-04-02 19:32:46Z UTC

1

Few issues here......the estrogen being up.....is it E1 E2 or E3? My bet its E2. And it could be because of aromatase induction. The progesterone elevation could be from several issues. Low T, real low DHT, or it could be from transient BPH. High progesterone in males is associated with low sex drive, bad sleep (low melatonin), shrinking manhood, and elevated BP. This really needs to be sorted out by a doc. You need to see one. Progesterone and cortisol elevation in men are very common things we see.........so don't fret get a consult. Good Luck

answered Apr 2 2011 at 19:32

The Quilt
27.4k●1●13●82

	Dr K... just wondering what kind of help a doctor could give on this outside of hormone replacement... – Bill Apr 3 2011 at 0:52
	age management doc or an endocrinologist......you have had a great effect on me.....tonight i opened a few books because of this post. I want you to get your iodone level checked. You could have a severe iodine deficientcy that is shunting E1 to E3.....(rare) or a choline deficiency that is leading to methylation problem in the methyl shunt......that would be shown by a high homocysteine level too. Still would check you PSA and prostate.....but you are an interesting case for a doc like me. I cant stop thinking about this clinical scenario because there is a multitude of reasons. – The Quilt Apr 3 2011 at 3:23
	read masterjohns blog on choline. This whole thread has really spurred me to write a blog. It is precisely why Panu paleo 2.0 will be an epic failure. Science is never that simple......and the answer lies in epigenetics. I know that sounds cryptic but its not meant too.....someday soon and it wont be long yall will get where i am coming from. – The Quilt Apr 3 2011 at 3:25
	the most common reason still to me.....wthout seeing and doing more labs is adrenal fatigue. I bet your cortisol is the driver. Its the most common reason progesterone is raised. – The Quilt Apr 3 2011 at 3:26
	Thanks for posting this thread......it clearly has stimulated my cortex. I think my teleomeres lengthened just thinking about the raminifications and machinations. – The Quilt Apr 3 2011 at 3:27

show 2 more comments

Stephen-Aegis · Answer 2 · 2011-04-02 23:11:43Z UTC

0

Avoid phytoestrogen rich foods. A quick google search will list them for you. I bet you're eating more than one. Also reference the jack my testosterone thread I detailed the food TO eat and why.

answered Apr 2 2011 at 23:11

Stephen-Aegis
24k●2●33●106

Yea, I've read the list, but since I've been paleo for 2 years now, eating unprocessed clean foods, organic when possible, etc. I think I'm in a way better position than your average person. – Dave Apr 3 2011 at 14:38

TheOriginalKaz · Answer 3 · 2011-04-02 23:17:37Z UTC

The accuracy of salivary hormone testing is debatable: http://www.aetna.com/cpb/medical/data/600_699/0608.html

[QUOTE]  Aetna considers salivary tests of dehydroepiandrosterone (DHEA), estrogen, melatonin, progesterone, or testosterone experimental and investigational for the screening, diagnosis, or monitoring of menopause or diseases related to aging, or any other indications because these tests have not been proven to be valid alternatives to serum tests.
[/QUOTE]

That said, if you confirm high progesterone via serum hormone testing, that can indicate a deficit in the 5a reductase type 2 isoenzyme, which is responsible for transforming progesterone into the neurosteroid allopregnanolone. Are you depressed at all?

High Progesterone & Estradiol in Male. Causes & Cures?

3 Answers