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I know whey protein is in the paleo gray-area, but when it comes to muscle growth and repair it's hard to beat. Is anyone knowledgeable about the differences/benefits between whey protein isolate vs undenatured whey protein? I have heard that undenatured whey is micorfiltered and not heated so the protein stays in tact, and has benefits that include boosting glutathione levels in the body....but are there any other reasons that undenatured whey is better than a plain old whey isolate? Or is whey protein isolate better for any reason?

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proserum, non-denatured is all Ive been recommended from chiropractors... – paleo12 Feb 14 at 3:43

22 Answers

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I've done quite a bit of research on this because Paleo or not, I do take whey protein at this time.

There's a fierce divide on this in the bodybuilding community. The vast majority of bodybuilders (especially the big guns) use the isolate because it is more concentrated protein. They also call it more 'pure', but that seems like a poke in the eye to the folks who claim that the concentrate is inherently more pure. This is because the protein isolates have gone through more processing that includes high heat and usually some acidic compounds. So when people say that isolates are more 'pure', they are really referring to the fact that isolates are just higher in protein content. So to use it in a casual sentence, it would be something like "Whey protein isolate is basically pure protein." And that is true. Isolates are usually in the 90-94% protein content range, while high quality concentrates most normally fall in at about the 75-80% range.

Non-denatured whey concentrate is technically more "pure" in reality, taking the literal meaning of the word. The cold processing is less brutal and many people report better digestion and absorption with concentrate because it is techincally concentrated whole proteins, versus isolated amino acids. The reason some people believe concentrate is not worth the money is because it has less actual grams of protein per ounce of powder. This is because a small portion of the concentrate is still the milk lactose. (really not that much though).

I believe the food quality of the cold processed whey protein concentrate is more natural (even though it is still processed into a powder) than the isolates variety. I like the fact that the cold processing of concentrate allows some of the beneficial bacteria to remain active. This also significantly boosts levels of the master antioxidant glutathione. As a bit of a side note, many of the concentrate options out there are made from grass fed cows, and while the fat of grass fed cows is where the goods are, the protein concentrate still does retain some of the naturally occurring CLA, which assists in developing lean muscle mass and shedding tummy flab. It worked for me. I am not necessarily against isolates though, as many people have experienced great results with that option as well. There is only one brand I know of that makes a non-denatured Isolate compound with no fillers or additives (in their non flavored version). I may try this one day. NutraBio..

UPDATE--> Nevermind on the NutraBio. I found that it does actually contain soy lecithin. It's not the worst choice for an isolates mix, but I now take BlueBonnet whey protein isolate - Original Flavor. It met all of the same criteria that I liked about the concentrate except much more reasonably priced. It's cold processed using no chemicals and/or dyes. It's grass-fed and has only 2 ingredients: whey protein isolates and vanilla. No soy lecithin. No sweeteners. No gums. It's also a great deal and tastes amazingly good.

Cheers!

(in case you missed it, check out the new answer from "Naz" below --> hilarious. "Jack is whack" haha +1.)

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+1! That looks like a really good deal. And kudos for compressing all the pertinent info into a single answer. I've been wondering about this and whey-related issues for a long time now. – Futureboy Apr 5 2011 at 18:16
Awesome Jack, this is very helpful thanks! – Dr. Ryan Apr 6 2011 at 1:52
hey thanks jack. im still on ON nutrition's but i'll check the bluebonnet when i re up. I've def read good things about their vitamin sourcing, etc. – ben61820 Jun 27 2011 at 21:29
Thanks Jack! Just the information I was looking for. – Eric Aug 19 2011 at 17:55
Jack: How would you respond to this? youtube.com/… – CP Dec 12 2011 at 18:19
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"It's grass-fed"

Not a slam but I just wanted to comment. Whey protein from an animal has a predetermined amino acid sequence which will not, can not, and shall not be changed by its diet. It is biologically impossible to tell the difference between grass-fed,grain-fed, or garbage fed animals with regards to their amino acid profile.

The difference is solely in the fat of the animal with regards to the types of acids present.

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what about CLA? – Jack Kronk Jan 5 2012 at 19:51
Actually it's not just the fat where corn and soy leave their signature. scientificamerican.com/… – Aughra Feb 23 2012 at 18:27
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what about CLA????? who takes protein powder for CLA? Maybe discussing the additional benefits in the actual meat of an animal things like CLA would come up, but certainly not in powder. – Bill1102inf Feb 27 2012 at 23:03
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check out the protein factory. Sale on mix of isolate and concentrate from grass fed austrailian cows. very reasonable.

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That's where I usually get my protein. Decent prices for quality protein. – James Sep 15 2011 at 2:24
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Master john posted a company that had whey that was completely unprocessed but quite pricey... I'll look up the name when I get home

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whey cool is the whey we were talking about. I asked Chris today and this was the answer. – The Quilt Apr 6 2011 at 2:51
Cool thanks Doc – Dr. Ryan Apr 6 2011 at 12:38
I have been using Whey Cool for PWO drink for about 6 months. I recently switched due to price only because I found myself limiting the amount I was willing to consume. It's $60 for 30 servings. Compare that to other options and you can see that Whey Cool is pretty expensive. Right now I am using True Whey from Source Naturals and just tripple scooping the serving for 24g per PWO shake. iherb.com/…. Still much less expensive than Whey Cool for nearly the same product. – Jack Kronk Apr 6 2011 at 14:15
What are opinions of the product Whey to Go by Solgar vitaminshoppe.com/store/en/browse/… It says microfiltered, no RBGH cows, no artificial sweeteners and reasonable price – Dr. Ryan Apr 8 2011 at 19:06
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What silly speech goes on here. Listen to what bodybuilders do take the isolate. Jack is whack with that teenage scrawny body, you cant takes hm serious style. Jack, go be a real man and put down the fake protein bro.

  • Naz
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haha! "You can't take hm serious style." Nice one. Welcome to PH Nazarath. Post a pic of yourself or I will just assume that I can toss you 10 feet with my scrawny body! lol. Oh and I take isolate myself now, but the concentrate is not fake. – Jack Kronk Jun 27 2011 at 20:08
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I have a hard time taking someone who uses the word "BRO" seriously. Just reminds me of the stupid kids who hang out in front of the beer store asking the adults "Can you get me a six pack bro". – james barlow Aug 21 at 19:36
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Personally, on the very rare occassion that I do consume whey, I use the fully denatured Isolate b/c all I want is the amino acid profile and none of the bovine growth factors.

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Depends on what you're looking for. Whey's used for several different things. For the health/immune system aspect, you want undenatured whey (an undenatured whey concentrate). For the bodybuilding aspect (muscle repair, glutathione levels, etc.), you want the isolate (higher protein amounts). I use CFM Isolate after my exercising.

This is not saying that that concentrates don't help muscle repair or that isolate doesn't have the health aspect. I see it more as a scale. Isolate's lower on the health scale and higher on the muscle repair. Concentrates are lower on the muscle repair and higher on the health.

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with no disrespect to any of youse, yall are all clueless. None of that stuff matters - your'e wasting your time and money. Muscles can get big and have gotten big with out any of that fake crap - whey or isolates or what ever crap they come up with in the next decade (pooh protein ??). Eat some raw this some raw that - have some pasta, drink water and pump real heavy steal/iron - you'll be big and strong and healthy. And seriously, clueless just means not knowing the real truth about something - it doesn't mean you're stupid.

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No disrespect to you either, but you don't make a very strong case for your point. "have some pasta and drink water"? Seriously? You can also try to get all essential vitamins and minerals from food and forego all supplements. But does that mean anyone who takes any supplements is clueless and wasting their time/money? "Muscles can get big and have gotten big with out any of that fake crap". Obviously, but that wasn't the point of this question. Leaping to a conclusion from one true statement doesn't always guarantee you have leaped to a sound conclusion. Oh, and welcome to PaleoHacks :) – Jack Kronk Jan 5 2012 at 20:11
All I can say is wow. Thanks for covering this one Jack. – Dr. Ryan Jan 23 2012 at 2:10
Hey, you mad bro? – Anondson Aug 25 at 22:49
Yep, poo protein is just around the corner. Gut bacteria (what poo is mostly composed of) have lots to do with how you absorb nutrients. – meta Aug 26 at 3:25
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The Bluebonnet brand lists in their supplement info that it contains milk and soybeans. I'm not sure what the difference is in that and soy lecithin...but thought I would point that out if you are trying to stay away from soy altogether.

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My emailed question to Bluebonnet: "The ingredients do not list soy lecithin. Can you please confirm whether or not it has soy lecithin in it at all?" – Jack Kronk Jan 5 2012 at 19:50
Their response: "There is no soy lecithin in the Whey Protein Isolate, however the Dual Action does have a bit of soy lecithin." – Jack Kronk Jan 5 2012 at 19:50
Really? This was their response to me..."The soy lecithin is used in the agglomeration process to instantize the whey to enable to stir into liquids, it is a minute amount, as whey needs a lipid to keep it from flying asunder when opened as well." The question I asked was, "Your whey protein isolate does not list soy lecithin in the ingredients, but the label says "Other ingredients: Undenatured whey protein isolate, natural vanilla flavor. Contains: Milk, soybeans". What form of soy is in the whey protein isolate that the label would have to list soybeans in the contents?" – Rachel Jan 18 2012 at 14:38
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**I started a new link for this...because I didn't see the "email me" box. Please respond to the new link if you can assist in locating the protein I need.

I am on the hunt for an un-denatured (non-denatured) whey protein that does not contain malt, as malt breaks down into MSG.

My bestfriend has a neuro-degenerative disease and the diet calls for this criteria; yet I can't find a protein powder that satisfies the Gluten Free/ neuro-degenerative needs of the diet. Help would be greatly appreciated here.

***One small comment here about adding supplements to ones diet; back in the day we didn't need to supplement our diets because we were not exposed to the stresses our bodies are exposed to now. Today we have an abundance of toxins in the air we breathe, water we drink and foods we buy in a rush. To adequately combat what we are exposed to, supplements are a good option if we consume the correct ones in the "purest" form possible.

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Whey protein is going to do no more to combat the stresses of toxins than fresh food. – Warren D Jun 5 2012 at 5:28
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Check into Isagenix.

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Totally confused by all of you. What I need is a clean Whey product, without, soy or lecithin. I am trying to gain weight, and will use it to supplement meals. In all of your humble opinion, which is best for me, a senior female, who still works out, and cannot hold onto weight due to fast metabolism, and lifestyle. Thanks.

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Good luck with that. Lecithin is added to the vast majority of whey proteins to instantize them (make them dissolve quickly in water). Most of the whey proteins I've seen that specifically contain no soy lecithin contain sunflower lecithin instead. I did, however, find this one with egg lecithin: proteinfactory.com/shop/soy-free-whey-protein – Alex Jun 5 2012 at 3:44
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If you are looking for a protein without soy or soy lecithin you can check out Arbonne Protein it is vegan made with pea cranberry and brown rice. It has 20 grams of protein per serving. Comes in vanilla, chocolate and there re flavor packs if you want to change up the taste without adding other fruits vegs etc. It is great for those with issues with dairy,egg etc. Check out my site under shop online Essential Fit. This is a thirty year old company that puts lots of time into finding products that show results.

www.gduncan.myarbonne.com

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here's a grass fed whey protein with no soy and sweetened with stevia

http://www.lifesource4life.com/protein.html

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Jack Kronk, I cannot tell you how wrong you are.

The definition of denature is: Biochemistry . to treat (a protein or the like) by chemical or physical means so as to alter its original state.

Whey protein comes from cheese. Which is pasteurized 2 times, once from the milk and again for the cheese. This is an FDA requirement. Pasteurization is adding HEAT to kill of bacteria, therefore denaturing the various compounds and proteins. This is a marketing gimic.

As far as doing a cold-process, Cross-flow microfiltered Isolate is a cold process of isolating the protein. Less denaturization occurs because of that process.

Ion-Exchange Isolate is garbage compared to the rest. The process takes concentrate and then sodium hydroxide and hydrochloric acid are added, which denatures the whey even more.

Get your shit right.
-Andrew Donner BS Nutrition Certified Personal Trainer (ISSA)

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http://www.youtube.com/watch?v=cm9ULKdffCQ

Whey Protein: The Simple Facts


The guy explains it pretty well.

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I love protein shakes! http://www.formvote.com/discuss.php?postid=486346344474572

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In answer to the post by ‘reburns’ on Feb 23:

The non-denatured whey protein that you seek is produced by a company called Immunotec. The product name is Immunocal. The best information on the internet is at:

                 www.ForGoodImmuneHealth.com

This website, one of the best on the internet, provides several hundred testimonials and articles about non-denatured whey proteins and the impact that they have on immune system diseases, toxins and other things. Immunocal is clinically proven to enhance glutathione and provides energy to the body. It has been successful in mitigating/reversing many neuro-degenerative conditions. Briefly, Immunocal is made from cow’s milk but is specially processed. It is free of lactose, fat, and gluten. As well, it is free of preservatives, antibiotics, herbicides, pesticides and bacteria. Immunocal is produced as a pharmaceutical grade product, not as a food product, which means that every envelope has a serial number and a lot number thereby making it traceable. Packaging is done in an oxygen free environment by replacing oxygen with nitrogen.

I will provide more information in another post.

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On this blog, there has been a lot of discussion about non-denatured protein. Perhaps I can add some more information.

Non-denatured whey protein (also called undenatured whey protein) was discovered in the period 1981-1988 by Dr. Gustavo Bounous at McGill University in Montreal. He was testing a whey protein from a Swiss company and noticed that it had a beneficial impact on life span and disease resistance of rats. After much research, it was discovered that this whey protein produced that beneficial effect by enhancing the rats’ intercellular production of glutathione. Glutathione, which has been called the body’s master antioxidant, currently has over 103,000 articles on it in the US National Institutes of Health PUBMED database.

There are several books written about the development of Immunocal, all very good reads.

In order for cells to produce glutathione, they must have three precursors and the one precursor that is rate-limiting is double-bonded cysteine as it is not easily obtained by our bodies through diet. It turns out that this special whey protein provided the double-bonded cysteine to the cells and thus glutathione production was enhanced.

This double-bonded cysteine is very sensitive and if broken does not provide glutathione enhancement. It is broken by pasteurization at too high a temperature, excessive agitation and oxidation.

Thirty years of research by Dr. Bounous and his colleagues resulted in the development of a product called Immunocal. Immunocal is specially produced from cow milk using cold pasteurization with extensive screening and filtering. Immunocal is packaged in a nitrogen atmosphere to prevent oxidation.

Immunocal has around 100 patents, is recommended by the 2008 Nobel Prize winner for Medicine, Dr. Luc Montagnier, is listed in the U.S. PDR (Physician’s Desktop Reference), CPS (Compendium of Pharmaceuticals and Specialities), Pharmacists’ Red Book and is on the FDA’s website. As well, Immunocal is reimbursed by Medicare and Medicad in some states.

It has been cited for its beneficial impact on immune system diseases such as cancer, fibromyalgia, and many other such diseases. For more information and many testimonials, go to:

                    www.ForGoodImmuneHealth.com

which is one of the most extensive sources of Immunocal information on the Internet.

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If you want a whey protein undenatured without soy or soy lecithin but has sunflower oil powder, try going to http://caprawellness.isagenix.com/us/en/home.dhtml for a nutitional meal replacement/supplement and order the IsaLean Shake or IsaLean Pro depending on your protein needs.

However, the IsaLean Bars do contain some soy ingredients. They taste great but I would not recommend the protein bars if you do not want any soy ingredients.

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For great undenatured whey isolate, you can't beat Prolacta from Lactalis. This is a WPI that is extracted directly from skim milk via microfiltration first to separate the casein from the whey protein, lactose and ash. It is then ultrafiltered to separate the whey protein from the lactose and ash to create a concentrated source of whey protein. The whey protein only goes through a single pasteurization step and is not derived from a cheese making process. Lactalis sells it in bulk form and it is not instantized. The only retail source that I'm aware of is the Protein Factory and they buy it from Lactalis and have it instantized before selling it to the consumer. They also sell Wellwisdom's Proserum whey protein concentrate which is made much the same way.

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Try "Whey Factors" by Natural Factors 100% Natural Whey non-denatured

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