Dr. Cordain talks about the role of Insulin like Growth Factor Binding Protein-3 (IGFBP-3), IGF-1, "high levels of male hormones circulating in the blood stream" -- too much androgen, too little SHBG, dietary lectins, and "localized pro-inflammatory hormones called cytokines" (Interleukin 1 alpha) in acne.
I've eliminated high glycemic load carbohydrates, milk and other dairy products (except ghee), vegetable oils (except coconut and olive oil) and 4) grains and legumes containing dietary lectins.
Still something must be causing IGF-1 to be too high, too much androgens, or excess cytokines.
High protein diets can cause IGF-1 to increase, as can exercise that involves heavy lifting (squats?).
So what is the perfect diet and exercise regime for paleo acne?
Are pullups, ab workouts, and some medium-light intensity free motion machine (chest, biceps, triceps) exercises going to send IGF-1 too high?
If acne is non-existent in traditional cultures, then how can it be existent when eating little to no processed foods, inclusing lots of vegetables, grass fed beef, sardines, wild caught salmon, ghee, coconut milk, cococnut oil, red palm oil, omega3-egg yolks?
Is it a matter of eating more bone marrow and offal?
Or is acne just a matter of the facial skin being hyper-sensitive to some hormones at the follicle level (DHT, IGF-1,Interleukin 1 alpha, androgen, etc..), much as in the case of male pattern baldness?
Some on acne.org have described acne as "skin diabetes" -- and high chromium brewer's yeast has been hypothesized as a treatment, back in 1984: http://www.ncbi.nlm.nih.gov/pubmed/6236351
Basically I follow a diet that should reverse diabetes, but why isn't it working for "skin diabetes" aka acne vulgaris?