My aunt tested "positive abnormal" on Antinuclear Antibodies Direct. However, the doctor (hepatologist) failed to follow through and we have no idea which particular antibodies are responsible (e.g., RNP antibodies, Smith anbitodies, Sjogren's SS-A/B, etc.).
When I myself tested positive, my neurologist tracked it down and was able to pinpoint Sjogren's Anti-SS-B as the offending antiboddy. This resulted in my diagnosis of Sjogren's Syndrome. Going through my lab works, I now realize that I tested positive on "Antinuclear Direct" a year earlier on my nephrologist's blood order. He never followed through with it either.
When I tried to have the hepatologist follow through, she remarked that it doesn't seem to be causing problems and she could go see a rheumatologist if she's inclined. (My aunt also happens to suffer from chronic hepatitis B contracted early in life -- my understanding is that this too could be an autoimmune disease: could she be testing positive for this, then?)
Now, my question is, does testing "positive abnormal" on Antinuclear Direct imply a particular type of autoimmunity? Shouldn't she, for example, go see an endocrinologist instead, as she is 70 years old and seems to have mild, thyroid-related (rather than connective-tissue related) symptoms: fatigue, fungal toenails, etc.?
If you have Hashimoto's or Ulcerative Colitis, you would not test positive on ANA Direct? Is that only for connective-tissue related autoimmune conditions (RA, Sjogren's, Lupus)