Kurt Harris and Mark Sisson both argue that you don't need to eat 100% Paleo all the time. It seems to me if your goal is weight-loss that's pretty uncontroversial, while if you went Paleo for a specific illness you would probably go 100%.
In my case I came to Paleo for my heart and cholesterol numbers, confident that SAD was taking me to a heart-attack. I guess a lot of people on Paleohacks may have come to Paleo for the same reason.
So I want to ask opinions on whether there is some magic degree of fidelity for avoiding diseases of civilization, or some particular food that is absolutely non-negotiable for long-term heart outcomes.
My own guess is the absolute no-no-list is refined sugar and glutens, but I'm pretty new to Paleo so I want to hear from others.