Dr. Jack Kruse (on PaleoHacks formerly known as Dr. K and now known as The Quilt) is interviewed at Jimmy Moore's: http://www.thelivinlowcarbshow.com/shownotes/4119/474-dr-jack-kruse-low-carb-neurologist/
I enjoyed the entire podcast and appreciated his thoughts about context in terms of leptin.
Listen to the bit between 37 minutes to 38:54 -- wherein he talks about the importance of increasing carb consumption IN THE RIGHT CONTEXT i.e. after you have solved your leptin resistance via Paleo diet.
So -- how does one:
a) solve leptin resistance problems in your muscles and liver?
b) know when they have solved leptin resistance problems in your muscles and liver?
c) what the next steps are?
Awesome! Jimmy's site is being lame right now so I haven't listened yet.
I already knew about leptin resistance for the most part, although I am always revising exactly what I believe like with the carb thing. Dr. Quilt and I agree on many points although I suspect that I will learn plenty more once I listen. The thing is that leptin is an incredibly slippery issue. If someone hasn't looked deeply enough into the issue they're going to be mightily confused. Some people think that since elevated leptin produces leptin resistance, and in fact you need elevated leptin to produce leptin resistance that leptin resistance is the effect and not the cause of obesity. Compound that with the fact that adipose tissue secretes the cytokine Il-6 which increases SOCS-3 expression in the hypothalamus and causes leptin resistance, it all seems plausible. But you don't need any adipose tissue at all to elevate your leptin levels or your Il-6 or CRP. That's the thing about metabolic syndrome. Every effect in metabolic syndrome acts as a cause in worsening and perpetuating the metabolic syndrome, and one day one finds oneself at 300 pounds and is flabbergasted, hungry, and looking for answers.
The mechanisms that raise systemic inflammation in the body do not need adipose tissue or leptin resistance to arise, they can be produced by a disequilibrium of polyunsaturated fats, wheat lectins, nutrient deficiencies, endotoxemia, and plenty of other things. Inflammation will increases Il-6 and c-reactive protein and this can cause leptin resistance prior to obesity http://www.ncbi.nlm.nih.gov/pubmed/16582918 Sugar also raises leptin quite a bit, triglycerides can interfere with leptin signaling and there is just a lot of things that the paleo diet remedies that help things. I suppose the tendency to eat addictive foods to excess like Whole Health Source has been talking about plays a role, although I think that leptin resistance likely plays a role in that. They tend to be inextricable from each other so it's hard to tell.
Basically once metabolic syndrome gets a foothold we gain some weight, that fat makes things worse, and everything causes everything in a horrible downward spiral of death and doom. I'm not going to ramble about the issue here and I'm not particularly knowledgeable with the nuts and bolts, but I will say that there are definite things that people can do, but it takes some time to get everything right so they can lose weight and keep it off.
That's the thing, pat: every person out there says Leptin is the problem! But no one ever says what to do. It's always the same old story: whole body fat releases leptin so the more fat you have the more should release and thus you're not hungry and you lose that fat. But then of course there are the leptin receptors and everyone says well the receptors have lost sensitivity like for insulin and thus even with sky high amounts of leptin, your Body isn't "hearing" it. Fairly straight forward. Byron Richards has been saying this for years. Even Taubes acknowledges it. But no one can figure out what to do.
I'd love to see what the big reveal from the good doctor is
Dr. Kruse is the man. I was born in Nashville, still have family there. Need to check him out next time I'm down there. I really liked the point he made about the need for different diets for people based upon context. This is a good point and one that differentiates him from much of the Low Carbers. I could imagine these types of broadcasts turning into a Low-Car love-fest, but Dr. Kruse set himself apart politely on this point. Would like to know more about what these different dietary approaches look like in practice, so I'll read his books and look forward to his website going live. I also liked what he said about the relationship between medicine and research science. If X is true for 99.90 percent of the population, what if I belong to that .01 percent.
I really enjoyed the podcast, and I look forward to more info. I seriously need all the help I can get regarding inflammation and leptin. I've been at this for a while, and no matter how much I tweak my eating and exercise doing Paleo/Primal, I cannot seem to lose a significant amount of weight. Thanks Dr Kruse, I look forward to your blog.