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After about 2 years dairy-free paleo (with occasional cheats) I've been diagnosed with food induced histaminosis (histamine intolerance). I decided to get tested as many of the symptoms that initially improved while eating paleo returned after some time (bloating, diarrhea, asthma, eczema, increased heart rate after eating). Anyhow, I tested intolerant for wheat, dairy, chicken, egg white, oily fish and pork. The specialist told me to remove these foods from my diet for the next 6 months (in addition to histamine-rich foods and drink like wine:(

From my understanding, histamine intolerance occurs when insufficient DAO enzyme is produced to deal with the amount of histamine released by the mast cells. Since DAO is produced by the intestinal mucosa, in my opinion, a damaged intestinal lining would affect DAO production and, at the same time, allow proteins to slip through, which would cause the cells to release histamine. In short, I have a feeling that at this time, until I fix my gut lining, I will react negatively to pretty much all proteins. The problem is that I don't know how to fix it!!

So, here's my question: Should I actually stop eating ALL of the foods I am intolerant to or would I be able to cure things by just eliminating dairy and gluten (completely eliminating them, meaning no cheats) and including probiotics. I'm having a hard time figuring out how to continue to eat paleo while eliminating all of the proteins I am supposedly intolerant to. I prefer to eat low carb paleo to control my food cravings, too many carbs and I'm toast (LOL).

If a strict 6 mo. eliminating the foods I'm intolerant to is enough to go back to my usual paleo diet, I'll try it, but it would be really tough and restrictive. Any answers??

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I asked my doctor to test me for this, a functional medicine doctor, and she hadn't heard of an official test.(I am so tired of trial food avoidance tests) Will you please tell me the name of the test or the lab that did it? Thanks so much! – Senneth Jun 1 2011 at 20:51
Translated to English it is called a 3rd generation histamine release assay. There is a team of doctors/biochemists that perform the test in Seville, Spain. I could send you their contact info but doubt it would do you any good. There is a website: www.saeia.es – Primal Mama Jun 7 2011 at 14:57
Thanks! I am going to make my doctor check into it! – Senneth Jun 14 2011 at 22:36
@primal, I'm dealing with a very similar situation to the one you describe. How have these past nine months gone for you? I'd love to hear about your progress! – Charlie Feb 26 2012 at 20:30

8 Answers

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Check out the GAPS diet (specifically the intro phase), make sure sleep is good, manage stress to acceptable levels, do not do high intensity exercise, and watch any meds you're currently taking. Get with a practitioner hip on paleo and GAPS to explore possible supplementation. I like 1,3/1,6-beta-glucan here.

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Thanks:) Checking out GAPS sounds like a good idea. Finding a paleo/GAPS practitioner will be close to impossible, I'm in Spain and our health care system is a whole different ballgame. – Primal Mama May 29 2011 at 11:35
You could Skype with naturopath Chris Kresser. A lot of practitioners offer this now. – Jon Jun 5 2011 at 16:38
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At the very same time all my food allergies/intolerance were diagnosed I also noted issues with eating left overs, thats when they explained to me about histamines in foods, and that includes eating left overs....which I reacted to, of the very same foods I could eat the previous day without issue.

I think when you are really suffering you are so much more sensitive to things so its best to remove them completely and eat pure fresh foods that are allowable.

Definitely look into GAPS intro, you need to heal your gut ASAP. What will eventually happen if you dont, is what I'm currently facing, new and an ever growing list of new intolerance.

Are you at least absorbing nutrients? Id be careful with supplementations when you are so sensitive, make sure you get allergen free products and try things slowly to make sure you dont react!

I feel for you!

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You are probably right about removing all offending foods, I just don't know how I'm going to do it. If you don't mind me asking, what steps are you currently taking to improve your gut? – Primal Mama May 29 2011 at 11:33
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Have you tried the autoimmune version of the paleo diet? You'd have to continue with the no dairy but also eliminate nightshades, eggs and nuts/seeds.

Also this might be a great question to ask Robb Wolf. If he responds could you post his response here, I'm sure we'd all like to hear his opinion.

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Yes, thing is that the autoimmune version is pretty restrictive and if I'm going to attempt such a strict diet, I might as well eliminate all the foods I am intolerant to first. I guess I'm just looking for an easy way out here... – Primal Mama May 29 2011 at 11:37
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Dr Art Ayers talks about healing the gut by consuming firbrous products. He specifically mention artichokes, jeresalem artichokes, jicama, burdock root, and chicory as fermenting in the gut which will assist in healing the gut. I obtained burdock root and chicory at http://www.herbco.com/ I mix the burdock root and chicory in my yogurt. The burdock root is fibrous and hard so I soak a couple of minutes in water before adding to my greek yogurt.

He is all about healing the gut which will rid the body of inflammation.

http://coolinginflammation.blogspot.com/

Jimmy Moore is going to interview Dr Ayers June 2nd.

For those that have muscle aches which may be fibromyalgia, Supplementation with 5000IU Vit D3 daily...the gelcap...seems to help with fm.

The Quilt doctor wants his patients to maintain serum Vit D3 at 70 to 100ng/ml I started with 10000IU daily and then backed off to 5000IU and wife and my level is around mid 80s.

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But do you think it is necessary to give up all of my beloved protein in order to cure the gut? Will the intolerances clear up as the gut heal or is it necessary to remove offending foods for the gut to clear up? – Primal Mama May 29 2011 at 16:26
How about going 75%-80% fat, 15% protein and less than 5% carbs? And yes, eliminate all the foods your specialist said to. After all, you paid for the advice, now use it. Or if you have not hit bottom yet, continue your current eating habits...expecting a different result. Eat beef, beef liver, bison, lamb, leg of lamb, a few tuber yams. Cook everything you eat in lots of coconut oil. Pan fry in coconut oil. 1 TBSP coconut oil is 117cal. – Dexter May 30 2011 at 2:32
Any veggies you eat, drizzle coconut oil on them. Yes, it is restrictive, but do you want to get well or not? After 6 mo then you can start adding one old food at a time to test for a month. Would suggest adding back eggs first for the choline. And eat beef liver 2x week plus beef heart both panfried in coconut oil. You eat beef for breakfast in the coconut oil, you will not have to eat lunch, then evening have lamb. Use rosemary, thyme, garlic, bay leaf in the coconut oil for new flavors to impart to the coconut oil which will flavor the meat. Good luck to you. You must be your own doc. – Dexter May 30 2011 at 2:38
Good coconut oil is Nutiva brand in 54oz containers available for about $21 ea at swansonsvitamins.com shipping $4.99 and they also have the Now Brand 5000IU Vit D3 gel caps. – Dexter May 30 2011 at 2:45
And what happened to your blog since 11 Mar? Record everything you are eating as a reference for later. – Dexter May 30 2011 at 3:31
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This woman is considered one of the experts in histamine intolerance and her interview on radio is here

http://stream1.ihealthtube.com/podcasts/104.mp3

More detailed explanation here:

http://www.allergynutrition.com/resources/FAQ/4/Histamine%20intolerance.pdf

Here Diet http://www.urticaria.thunderworksinc.com/pages/lowhistamine.htm - Janice's diet only differs to this in the exclusion of eggs.

Other things which I find essential: Anti-histamine (Types 1 & 2) Mast-cell blockers (Intal - for stomach)

GREAT care with all medications - some can release histamines and cause great mischief

I have looked at the GAPS diet and I am trying bits of it but I am not able to tolerate much and adding fermented foods is just not an option for me and seems to be the basis.

The issue as I understand it in a nut shell is that histamine intolerance is genetic and reactive to hormones. I personally think for me addressing the histamines and blocking them is the precursor to anything else.

Hope this helps

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Very interesting. I am as well histamine intolerant.

GAPS diet may be great to heal the gut, but I think it's NOT an option for people affected by HIT. All fermented foods are very high in histamine, so basically what you'd need to consume in order to cure your gut is what makes you sick in the first place. A vicious circle. See here: http://huntgatherlove.com/content/sacred-cows-can-fermented-foods-make-you-sick

I don't think proteins are the problem, the problem is histamine, so if your intolerance is very severe you need to have VERY fresh meat, avoid slow cooking, and of course avoid all fermented foods and other histamine rich or histamine releasing foods.

I still don't know how to solve this, but eating liver may help. I am now experimenting with it as histamine breakdown is done by diamineoxidase (DOA), which is a copper-regulated enzyme. It is speculated that low levels of this enzyme cause HIT. I also had elevated LDL, which Paul-Jaminet says might be related to copper deficiency. It's a wild guess but we'll see. More on this here: http://paleohacks.com/questions/122016/high-ldl-and-histamine-intolerance-could-be-related-and-caused-by-copper-deficien#axzz1vrtJFq4n

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Sheesh..wheat caused mine. After I totally quit grain, I can breathe. My muscles ache though. so I am giving up bacon and any other processed type chemicals that could be added to food. What also helped was organic micro filtered whey in water for a few days... Fasting for a week with just water would also calm it all down for me.. I hope you can find your answer.

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Thanks organic one! I could never fast for a week!! But I am going to try and skip a few meals here and there to give things a rest. – Primal Mama May 30 2011 at 9:32
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Upvoted, and waiting/hoping for more answers too! I've also been considering the GAPS intro.

Wish I had some insight for you. I'm prolly in the same busted boat...

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I'm going to read the book this summer. Good luck with things. I know how frustrating it is:( – Primal Mama May 30 2011 at 9:33

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