There have been reports of 'ultra-bad' LDL cholesterol particles.
These are smaller and denser LDL particles that change shape and stick to the artery walls, causing poor blood flow. Not sure if these are the same, smaller LDLs that you can distinguish from the "large and fluffy" ones through VAP tests. My impression is that they are a subset of the small LDLs.
The crux is that these amorphous, small LDLs result from "glycation" -- i.e., glycation with sugar. Supposedly, this occus when LDL particles bind with fructose or glucose.
What is the implication of all this? My reading is that this new discovery could piggyback on Gary Taube's recent article castigating sugar. It could finally shift focus away from saturated fat in increasing cholesterol, especially LDL cholesterol.
In other words, doctors and the Big Pharma can still claim that LDLs matter, but single out sugar as a dangerous substance responsible for increasing the really bad LDLs. Perhaps I'm being too optimistic. But this could be a way for both doctors and the Big Pharma to save their faces, yet take their treatment for heart disease in a new direction that emphasizes sugar avoidance. Whadddya think?