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Let's say an obese individual loses a bunch of weight. From what I know regarding Leptin, (which isn't much, I'm workin on it...) said individual should have lower levels of Leptin as a result of the weight loss. At what point, if at all, does lower Leptin level have deleterious effects? i.e. down-regulating certain bodily functions?

Could this be a factor in why body builders who have such low body fat levels, have reproductive issues?

Taking this further, if one who is more interested in maintaining sub 10% BF levels (which I think may not be ideal for optimal health, but definitely takes your swagger up a notch) Would carb re-feeds intended to reset leptin levels be almost necessary, for overall health?

Edit: Added Link to a study that touches on this

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The sweet spot is staying leptin sensitive at all times......then you build upon that from there. If your leptin sensitive then you have to assess the other levees that support health. It a process of detection to get you back to your optimal self. Diet alone is not enough for many folks.....for many it is enough. Its all context.

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And how does one stay leptin sensitive at all times? – Brad Jun 2 2011 at 3:27
I guess that's what I'm trying to figure out. Is how to get to that sweet spot, what one has to account for at said sweet spot, and how do you KNOW you're at the sweet spot. I completely agree with the context thing. – Todd Jun 2 2011 at 4:37
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Carb or calorie refeeds can only "reset" leptin levels while you are doing it. Leptin levels respond as soon as you go back on the diet.

See this thread where Tyler answers.

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