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This seems to go against everything I've been reading in the last year. Anyone have an opinion as to what's going on in this study? It looks like the "risk" factor was the ratio of total cholesterol : HDL, and replacing SFA with PUFA resulted in a better ratio.

EDIT: Oops - http://www.ncbi.nlm.nih.gov/pubmed?term=20351774

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you forgot to post the link Jimbo :) – Jack Kronk Jun 14 2011 at 23:47
Sorry! ncbi.nlm.nih.gov/pubmed?term=20351774 – Fred B Jun 14 2011 at 23:52

2 Answers

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This meta-analysis bothered me too when it was first released. I asked the Paleohackers for perspective, and received some great responses.

Stephan Guyenet also weighed in on his blog.

To quote HealthRediscovery, "This paper is a breathtaking example of how far a person will go to confirm his own pre-existing ideas."

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Great, thanks. Every time I see a study like this, it seems I search a little and find someone already debunked it – Fred B Jun 15 2011 at 1:03
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Maybe a link to said study?

Without looking at the study, SFA can affect total cholesterol levels. So replacing SFA with PUFA in a short term study, may give you a better 'number', but did people actually develop less CHD?

Chris Master-John made an observation on Chris Kessler's podcast that it appears to take around 8 years for cholesterol studies to start producing useful results.

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