Trying to reconcile the complexities of both paleo science and my own individual health. I'm starting to understand that an underlying state of chronic inflammation is a source of many problems and disease states. I've also experienced the power of a paleo approach in reducing inflammation, but I'm wondering what to do if diet, supplementation, and movement are unable to calm it completely. In other words, if you've done everything "right" (or at least don't know what else to try) and you still live with a certain level of pain and inflammation, do the anti-inflammatory benefits of taking, say, a low-dose NSAID, outweigh the damage they can potentially do? What would you do if you had to choose between chronic inflammation and medication? If that's a false dichotomy, what are other options?
Back Story: I'm a 40-year-old male diagnosed with ankylosing spondylitis at 14. Off and on NSAIDS and DMARDS since about 18. Have done well with Celebrex for 8 years, but a low-starch paleo diet has cut my required dose by 75%. Also have MAJOR heart disease in my family (none in me yet) so am scared shitless of the inflammation-heart disease relationship. I'm sure there's something I'm missing paleo-wise, but I can't seem to figure it out (the permutations and combinations of diet, supplementation, and exercise are overwhelming). I've gone without Celebrex for the past two months, but my level of pain and inflammation is creeping back up and limiting my activity level.