Some of you have been posting that LDL skyrockets when doing Paleo. I've beend doing some research why that might be the case. One possible answer is offered by Dr. Joe Goldstrich, (most recently of the Princeton Longevity Center) who used to head the Pritikin Longevity Center in Santa Barbara -- that was back when the Pritikin diet duked out with the Atkins diet: Atkins was high fat, Pritikin was low fat.
This is from the website, Prescription2000 http://www.prescription2000.com/ which features interviews with health practitioners from the low-fat perspective (Cordain was on). Goldstrich is somewhat Paleo-friendly, though he's against saturated fat a la Cordain.
To summarize, what matters is the Apolipoprotein E (ApoE), a lipoprotein that carries cholesterol through the bloodstream. Dr. Goldstrich says you should know your ApoE status before deciding what type of diet to pursue. There are 3 kinds of ApoE: types 2, 3, and 4. And since we have 2 alleles, we can have combinations of 2-3, 3-3, 4-3, 4-4, so on.
For about 65% of the population, the ApoE status is 3-3. If you're 3-3, you can eat fat without unduly raising LDL. That is, those who seem to be thriving on the high-fat Paleo or low carb diets, judged only by their LDL, may have Apo E 3-3 alleles.
For the remaining 35% of the population, about 25% include type 4: e.g., 4-3, 3-4 or 4-4. These people's LDL may skyrocket on a fat-heavy diet, especially saturated fat. And the LDL increase may be in the form of Pattern B (the small, dense ones that are supposed to be dangerous). These people tend to thrive on a low-fat diet, as their LDL would be managed best by keeping saturated fat low. For example, eating coconut oil might increase their LDL significantly, while it would not affect the Apo E 3-3 type. Fish oil could also increase the LDL of these people, while supplement Quercetin could lower their HDL.
What does this sound like? Metabolic typing anyone? I dismissed metabolic typing when Dr. Harris pooh-poohed it. But maybe there is something to it.
Conclusion: About 65% of all dieters could benefit from a high-fat diet, but 25% may not. We're talking just in terms of their lipid numbers. Whether you believe in the lipid theory is another question altogether, however. So check your ApoE status if Paleoing seems to give you high cholesterol.