Paleo Diet and Paleolithic Diet Questions & Answers

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While doing research about leptin, there is a lot of information, studies and theories on how leptin interacts with the receptors in the hypothalamus to throw off the satiety meter and get the ball rolling on all types of nasty maladies. What there seems to be less information, studies and theories about are the leptin receptors on the muscles and organs(particularly the liver and pancreas).

Are the receptors on the muscles and organs disregulated by the same mechanisms as the the receptors in the hypothamus(high omega 6/3 ratio, fructose, lectins)?

Do the receptors in the pancreas regulate beta cell production of insulin and is faulty receptors the reason that beta cells die off in diabetics?

Do the leptin receptors in the muscle determine skeletal muscle insulin resistance?

Do the leptin receptors in the liver control hepatic insulin resistance?

It seems that in all the places that insulin resistance originates there also seems to be leptin receptors there. How is it that leptin seems to be the kingpin but the street thug insulin always gets heat from the obesity cops?

flag	asked Jul 26 2011 at 16:46 luckybastard♦ 12.5k●1●14●65

	There are leptin receptors everywhere......even your tastebuds – The Quilt Jul 26 2011 at 17:06
	The key is proteomics adaptions at receptors caused by foods that allow it. I went through some this in my two AD blogs because it appears that is precisely how hormone receptors are damaged and why levels don't matter in some cases. Omega sixes really cause it due to lipid per oxidation. Fructose too..... – The Quilt Jul 26 2011 at 17:08
	thanks, quilt. i've read both of your posts on it. so oxidation of the receptors is what makes them faulty? – luckybastard♦ Jul 26 2011 at 17:19
	so does it send signals to the beta cells? does it determine skeletal muscle insulin resistance? i'm curious as to the signaling mechanism... how does the faultiness of the receptor impede that... – luckybastard♦ Jul 26 2011 at 17:23
	Not just oxidation.....glycation too! – The Quilt Jul 26 2011 at 18:47

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Aravind · Answer 1 · 2011-07-26 17:03:24Z UTC

LB,

Leptin was discovered in 1994 and Insulin back in the 1950s (I think). Without getting into the biochemistry of your question, I view it similar to the fixation with cholesterol.

For 50 years now we have been developing, refining, attacking, attempting to falsify the lipid hypothesis and still continue to do so because of inertia, which is VERY difficult to overcome. Not sure if it will ever be overcome in my lifetime.

I think as the role of leptin continues to be clarified, including causal vs correlative factors, this might change.

In the meantime, I will continue to

Avoid gluten
Avoid excess fructose
Avoid excess O-6
Avoid soy and problematic legumes
Try to get adequate sleep (but failing miserably given the PH addiction)
Still my mind (even more of an issue than the previous point given the orthorexic tendencies)

Ok back to work...Seacrest, out

leptin receptors

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