While doing research about leptin, there is a lot of information, studies and theories on how leptin interacts with the receptors in the hypothalamus to throw off the satiety meter and get the ball rolling on all types of nasty maladies. What there seems to be less information, studies and theories about are the leptin receptors on the muscles and organs(particularly the liver and pancreas).
Are the receptors on the muscles and organs disregulated by the same mechanisms as the the receptors in the hypothamus(high omega 6/3 ratio, fructose, lectins)?
Do the receptors in the pancreas regulate beta cell production of insulin and is faulty receptors the reason that beta cells die off in diabetics?
Do the leptin receptors in the muscle determine skeletal muscle insulin resistance?
Do the leptin receptors in the liver control hepatic insulin resistance?
It seems that in all the places that insulin resistance originates there also seems to be leptin receptors there. How is it that leptin seems to be the kingpin but the street thug insulin always gets heat from the obesity cops?