Paleo Diet and Paleolithic Diet Questions & Answers

Question

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How does one minimize IGF-1?

edited Aug 25 2011 at 6:20

asked Aug 25 2011 at 6:14

Eric
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H.T. Neville · Answer 1 · 2011-08-25 06:43:17Z UTC

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Why would you wish to?

answered Aug 25 2011 at 6:43

H.T. Neville
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I am cooking for a friend with cancer and I am thinking that minimizing the IGF-1 impact and insulin response of the meals might help... – Eric Aug 26 2011 at 7:15

Suz - Paleo Oz · Answer 2 · 2011-08-25 06:49:24Z UTC

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Have you seen Pedro Bastos fantastic AHS lecture? IGF-1 came up lots as I recall... http://www.slideshare.net/ancestralhealth/ahs-slidespedro-bastos-8827808

*edited to say - check out the slides from page 50

answered Aug 25 2011 at 6:49

Suz - Paleo Oz
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Have not seen the lecture, took a look at slides; looks like John McDougall redux. Although I believe Denise Minger's site has some stuff on dairy and disease, and it's all in dairy's favor, LET'S ASSUME foods which increase IGF-1 (or action of) have some bad effects, such as promoting tumor growth, at least under some conditions. Have you weighed those possible bad effects against the good ones? – H.T. Neville Aug 25 2011 at 7:15

Lizzish · Answer 3 · 2011-08-25 07:33:56Z UTC

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When Mat LaLonde was on Robb Wolf's podcast (during the AHS), he mentioned that IGF-1 in dairy is destroyed by fermentation.

answered Aug 25 2011 at 7:33

Lizzish
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Karen · Answer 4 · 2011-08-25 10:23:10Z UTC

Protein restriction seems to work, at least in combination with a calorie restricted diet. "Reducing protein intake from an average of 1.67 g kg(-1) of body weight per day to 0.95 g kg(-1) of body weight per day for 3 weeks in six volunteers practicing CR [calorie restriction] resulted in a reduction in serum IGF-1 from 194 ng mL(-1) to 152 ng mL(-1)." http://www.ncbi.nlm.nih.gov/pubmed/18843793

Evelyn aka CarbSane · Answer 5 · 2011-08-25 14:14:26Z UTC

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I'm with H.T. I'm not sure why you would want to.
I blogged on a study demonstrating increased protein content in the diet increasing IGF-1 and improving glucose homeostasis: http://carbsanity.blogspot.com/2011/06/protein-insulin-like-growth-factor-1.html

answered Aug 25 2011 at 14:14

Evelyn aka CarbSane
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I am cooking for a friend with cancer and I am thinking that minimizing the IGF-1 impact and insulin response of the meals might help... – Eric Aug 26 2011 at 7:16

How does one minimize IGF-1?

5 Answers