So I tried the food combination diet based on the book "Eating Alive" by Dr. Matzen. It essentially argues that because different types of foods digest at different rates and in different areas of the system, they should be eaten separately, and fully digested before you start with the next thing. So for example an apple takes about 1/2 hr to digest whereas a steak takes about 6hrs. If you eat the two together, they will both start getting digested right away by the enzymes in your stomach, however some bits of apple will remain in your stomach while the digestive juices work at the steak and vice versa. If you overwhelm your stomach your body will use up all of the digestive juices and then you'll have to wait for it to replenish itself. During that time the food will essentially begin to ferment and/or rot in your stomach and you will experience bloating, fatigue, heaviness. The longer term effects are also that instead of properly extracting the vitamins, and passing the waste through, partially undigested materials will be stored and some of the good stuff will be passed.
Ugh, So In my personal experience, the most helpful thing that came from the experiment was developing a food awareness. I have continued for the past year to loosely observe a lot of the habits I developed during the experiment. For example, I always eat an apple or some other fruit (melon, citrus or berries) before I eat anything else, and I do not eat anything else for aproximately an hour. On a hungrier day I will combine nuts (generally almonds) with the fruit.
This allegedly stimulates the digestive system but doesn't deplete the good digestive juices. These excess juices will circulate through your body and "clean out" the other cells. It also creates a clean stomach for which you can eat your next meal.
I eat carbs (I should also mention that I'm celiac and by carbs I mean usually rice or millet, or GF oatmeal) during the day combined only with vegetables.
I eat protein in the evenings, fish, chicken, beef, egg, whatever - and generally only with vegetables, rarely with carbs or starches.
Dairy on its own, or with veggies. (I eat very little dairy already so this didn't bother me)
While being super strict I was absolutely miserable - for example not being able to eat a gf baked muffin because there was egg in it, or could't have rice with my fish. Generally my meals were either carby and bland or unsatisfying (probably only because I was used to corn tortillas with meat in them, or pasta with meatballs, as examples) I also found it super lonely, one of the things I love about food is sharing meals with people and being super strict is almost impossible in so many situations.
I notice food combination affects me when I "go nuts" like, for ex. if i eat a Burger while consuming alcohol, have apples in my salad and desert. I know for sure I'm going to feel awful.
Just as I began this, observing these rules for a period of time made me understand my own system better. Now when I feel crumby after a meal I'm usually able to be like yeah cause I had Ham and fruit spread. Or Cheese with carbs and meat. (or whatever) I always feel terrible when I eat fruit right after a meal - gassy, bloated.
End notes: sugar's the worst with anything and all the time. Being careful about what you eat should improve your life, if you're miserable, try something else.
Water fixes everything. Drink it plentifully and often. Feel gross after a meal? drink water, be patient and forgiving of yourself! And only drink water with meals (most of the time :).
Hope this is informative/helpful.