Let's say that an individual decides to implement the Paleo diet and was not leptin resistant prior. However, like most who begin paleo, their calories decrease, they go VLC and still continue or begin a high intensity training program several days a week. It seems to me that this would set you up to be insulin resistant and as Dr. K says, you cannot be insulin resistant without being leptin resistant.
I'm not saying necessarily that Paleo causes leptin resistance but can implementing a VLC Paleo lifestyle incorrectly and/or in combination with over training cause one to develop leptin resistance?
Cells being temporarily resistant to insulin is not the same as metabolic syndrome. VLC eliminates chronic and inappropriate insulin resistance and does not cause it. From how I read Dr. K, leptin resistance is due to a number of factors, but never have I seen that VLC is one of them. He says overtraining leads to cell death and stem cell depletion, not leptin resistance.
Anyone who has actually gone on a reducing diet while being leptin and insulin resistant usually sees an immediate benefit of VLC vs. CW weight loss. With CW, they are still always hungry, and with VLC, usually they aren't.
When I tried the LR protocol, my cravings were so intense I was climbing the walls and I only lasted 5 days then binged for another 4. However, once I regained my serenity I tried a partial approach where I have a protein/fat breakfast and eat my carbs in the 2nd or 3rd meal. My daily grams of carbs are over the VLC level recommended for the LR reset, but even so I'm noticing some benefits including great energy for my morning walks. I believe the protocol is the way to go if you can, but I've retreated to what I'm able to handle and my steady weight loss indicates it's helping.