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Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice.

Full free text:

http://cancerpreventionresearch.aacrjournals.org/content/3/5/653.long

First, in vitro:

"A combined extract of clove, oregano, thyme, walnuts, and coffee synergistically inhibited lipopolysaccaride (LPS)-induced NF-κB activation in a monocytic cell line, compared with the sum of effects from the single extracts."

Then, in vivo (mice):

"Based on the area under the curve, the extract decreased whole body LPS-induced NF-κB activity the first 6 hours by 35% compared with control mice."

Is this a good strategy for reducing systemic inflammation?

Or is it just another lame try to get me eating walnuts again?

(Note that one of the authors is a member of the Scientific Advisory Council of the California Walnut Commission)

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I think it is a good strategy for a terrible cup of coffee :) – Matt Oct 19 2011 at 15:07
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these are great things to add to MEAT :) – Bread-Eating Beelzebub Oct 19 2011 at 15:08
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True enough. Though I somehow doubt that a research paper on meat seasoning would have made it into Cancer Prevention :P – Matt Oct 19 2011 at 15:15
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+1 for the "wacky-shit" tag! – Dragonfly Oct 19 2011 at 15:24
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"All samples were pulverized and extracted and concentrated by use of water/methanol...The final extract was diluted in corn oil..." That would wake you up in the morning :) – Matt Oct 19 2011 at 15:51
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4 Answers

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Sounds like an experimental rub for a pork roast. Hmmmm...I've got a pork roast in the freezer and all that stuff in the larder - maybe I'll give this a go this week and let y'all know how it turns out!

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Or a great flavor profile for stewed beef or chicken. – curious Oct 19 2011 at 17:35
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I was thinking "things that could go in chili" (for 200 Alex). – Dave S. Oct 19 2011 at 17:51
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Ground cloves (not extract), yes. The rest? Hell no. I like to add a bit of cardamom to my coffee grounds as well. Both clove and cardamom brewed in a cup give it a nice flavor, reminiscent of chai tea.

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My local Lebanese cafe serves a Turkish coffee with Cardamom (not sure how it is added or at what point). Its so amazing!!! – Senneth Oct 19 2011 at 16:37
I like Turkish coffee! Don't really like getting a mouthful of grounds towards the end of the cup though lol. – Nemesis Oct 19 2011 at 18:23
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Maybe we can talk the guys who make the AeroShot to add these things to their inhalable caffeine product so we can give it a test?

http://gizmodo.com/5850615/aeroshot-pure-energy-ready-aim-caffeinate

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