I recently found out (from 23andme) that I am heterogeneous (one copy of the "bad" gene) for the MTHFR C677T polymorphism. This means that my body has reduced ability to convert folate into the active form of folate (5-methyltetrahydrafolate). From what I understand this means I am an under-methylator. I tend towards anxiety/depression which is sympomatic of problems with the folate cycle.
I have also learned impared folate metabolism can lead to elevated levels of homocystinine, which increases risk of cardiovascular and other health risks. Ok, fine. So I had my homocysteine levels tested and I am at 10.2umol/L.
It's at the high-end of normal, according to some such as Dr. Emily Deans who defines high as 11.3umol, others say 13, others say even higher. Given that homocystineine levels tend to rise with age, I think I should be somewhat concerned. What do you think?
What should an appropriate course of action be?
Is more testing in order?
Should I supplement B6? B12? 5-MTHF? Folate? A B-Complex? Seeking advice or anecdotes.