Leptophiles please help me out here. By now we are all keenly aware that Leptin is a bad mama jamma. She is the hormone that tells our hypothalami that we are full. She is secreted by fat cells. An overabundance of this lady annoys our brains and makes them ignore her constant nagging. This is bad because even though she is nagging and annoying she is telling our brains something very important - "Stop your eating already! You're getting fat!"
Leptin is also inflammatory - she'll screw a lot of things up in too high a dose for too long a time. But then here comes Ghrelin (not Gremlin although I wish it was called this because that was an awesome movie). Ghrelin as we know is the make you hungry guy. He makes us uncomfortable, but despite the discomfort, good things are happening - things like autophagy and reduced inflammation. I have heard that Ghrelin is the yin to Leptin's yang. When one is high the other is low.
I have also read that it is reduced autophagy in the brain caused by caloric excess that causes hypothalami inflammation, increased set point and accelerated obesity. I think that I read that it is hypothalami inflammation which is one of the major causes of leptin resistance.
So, given this, wouldn't the best thing to do when someone is "Leptin resistant" be to just to go hungry for a bit? I know it's easier said than done, but wouldn't the increased Ghrelin cause the chronically elevated Leptin to shup up for a bit? Wouldn't a little fasting or a reduced eating window (a la fasting) combined with reducing sugars and processed carbs eventually reduce brain inflammation and "reset" the Leptin switches?
*Since we are all so up on Leptin these days *8why don't we also hear more about Ghrelin? Is it not equally important? Since it is the anti inflammatory hormone shouldn't we be focusing on how to best live with it for longer periods of time? *
Maybe some focused non-eating time is just as important as the Paleo foods we choose to eat?
I dunno. I'm just trying to decomplicate the highly complicated Leptin shenanigans, but WAIT! Look up there - whammo! Shit just got complicated again. Dang it all - sorry.
But that's me - I am a simpleton. Any input into my above complicated question would be great. Thanks.
Little Miss Can't Be Wrong