I'm sitting in a lecture about nutrition and metabolism for people with diabetes. The instructor keeps insisting that if you are metabolizing ketones for any length of time, it will result in ketoacidosis, and eventually kill you.
I've not heard anything about LC and VLC paleo eaters having problems with ketoacidosis, but I'm not sure how we avoid it while primarily metabolizing ketone bodies. I understand that people with diabetes have more issues to work with, and are metabolically deranged, but how do people with normal metabolisms avoid acidosis issues?
Can anyone please shed some light on this for me? I googled around and haven't found explanation.
There are a lot of metabolic derangements going on in diabetic ketoacidosis. Very very simplified: in a healthy person, ketone production will be kept in check by insulin. Even on a low carb diet, a healthy person doesn't produce zero insulin. But in a state of absolute insulin deficiency like uncontrolled Type 1 diabetes (DKA isn't as common in untreated type 2, though it can happen), the pancreas can't produce any insulin in response to increasing ketone body production, so they accumulate to dangerous levels.
The body does have a bicarbonate buffering system that helps maintain blood pH, but it eventually becomes overwhelmed by this pathological production of ketone bodies, hence the metabolic acidosis.
Check the table in the end in the following link:
In a nutshell, as Olivia has mentioned, ketogenesis is controlled by:
Uncontrolled diabetics have no insulin or a non-functional isoform. This causes
The nutritionist is incorrect. Ketoacidosis is caused when there is an extreme build-up of ketones. This is not the same as ketosis. Ketosis just occurs when components are being broken down into ketones and then burned in cells, instead of burning glucose. Usually, these ketones don't build up, they are used up, which is another reason why ketosticks aren't a good indicator of whether someone is fat-burning. Why go to the bother of making ketones and then just peeing them out?
I have recently started the Paleo diet, and am a Type 1 Diabetic. IN attempting to adjust to this diet, I have been experiencing moderate ketones in my urine. I believe this is happening as my body just releases glucagon because it thinks that it is starving. I would really like some feedback/advice, as I would like to stay on the Paleo plan, but cannot do it at the expense of going into full blown ketoacidosis. I have never had a problem with ketones before I started this plan, and my blood sugars are higher than ever! I would appreciate someone shedding some light on this, or refer me to sources that can help.
i discussed this issue with my daughter's endocrinologist and posted here, but my post was closed b/c it was considered to be duplicate to this post.
for the record, my daughter is a Type 1 Diabetic (T1DM). This is NOT Type 2. It is b/c the body stops making insulin.
my daughter's doctor (professor of endocrinology and chair of childhood diabetes dept.) said that ketosis is just the step before too many ketones enter the bloodstream, causing ketoacidosis. ketones are acids that are, EVEN IN SMALL DOSES, harmful to the kidneys and liver.
my daughter's doctor said that chronic ketosis could be damaging to one's liver and kidneys.
my post was closed, but here is a link:http://paleohacks.com/questions/118163/ketosis-ketoacidosis-just-a-difference-of-degree-so-why-promote-ketosis-clos#axzz1ubRXdzx8
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